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Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

Rygula R, Clarke HF, Cardinal RN, Cockcroft GJ, Xia J, Dalley JW, Robbins TW, Roberts AC - Cereb. Cortex (2014)

Bottom Line: To address this apparent discrepancy, the present study determined whether both effects could be found in the same animals by performing localized 5-HT depletions in the amygdala or orbitofrontal cortex (OFC) of a New World monkey, the common marmoset. 5-HT depletion in the amygdala impaired response choice on a probabilistic visual discrimination task by increasing the effectiveness of misleading, or false, punishment and reward, and decreased response suppression in a variable interval test of punishment sensitivity that employed the same reward and punisher. 5-HT depletion in the OFC also disrupted probabilistic discrimination learning and decreased response suppression.Computational modeling of behavior on the discrimination task showed that the lesions reduced reinforcement sensitivity.A novel, unitary account of the findings in terms of the causal role of 5-HT in the anticipation of both negative and positive motivational outcomes is proposed and discussed in relation to current theories of 5-HT function and our understanding of mood and anxiety disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Current Address: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neurobiology and Drug Development, Institute of Pharmacology Polish Academy of Sciences, ul Smetna 12, 31-343 Krakow, Poland.

No MeSH data available.


Related in: MedlinePlus

Depletion of 5-HT in the amygdala or OFC abolishes punishment-induced suppression but leaves intact sensitivity to aversive outcomes. (A) Total responses made by 5-HT amygdala- and OFC-depleted animals and sham-operated controls before (open bars) and after (hatched bars) the introduction of punishment. (B) Change in responding after punishment introduction. (C) Log latency to complete trials after the VI schedule has elapsed and (D) log latency to initiate responding after receiving punishment and reward. Data presented as mean ± SEM, *P ≤ 0.05, **P ≤ 0.01, aP = 0.068.
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BHU102F4: Depletion of 5-HT in the amygdala or OFC abolishes punishment-induced suppression but leaves intact sensitivity to aversive outcomes. (A) Total responses made by 5-HT amygdala- and OFC-depleted animals and sham-operated controls before (open bars) and after (hatched bars) the introduction of punishment. (B) Change in responding after punishment introduction. (C) Log latency to complete trials after the VI schedule has elapsed and (D) log latency to initiate responding after receiving punishment and reward. Data presented as mean ± SEM, *P ≤ 0.05, **P ≤ 0.01, aP = 0.068.

Mentions: Upon completion of the probabilistic discrimination and reversal stages and following in vivo microdialysis, the sensitivity of all animals to punishment was assessed. Using a VI schedule of reinforcement (20 s) that provided equal opportunities for reward delivery on both sides of the touch screen, experimental groups did not differ in their total number of responses for reward only (Fig. 4A). In contrast, upon introduction of the 40-s VI punishment schedule, with equal frequency of aversive loud noise (0.3-s duration, 108 dB) on both sides, the response suppression that occurred in the controls was not seen in either of the 5-HT-depleted groups (Fig. 4A,B). Indeed, both depleted groups increased their total number of responses during the punishment phase compared with the reward-only phase.Figure 4.


Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

Rygula R, Clarke HF, Cardinal RN, Cockcroft GJ, Xia J, Dalley JW, Robbins TW, Roberts AC - Cereb. Cortex (2014)

Depletion of 5-HT in the amygdala or OFC abolishes punishment-induced suppression but leaves intact sensitivity to aversive outcomes. (A) Total responses made by 5-HT amygdala- and OFC-depleted animals and sham-operated controls before (open bars) and after (hatched bars) the introduction of punishment. (B) Change in responding after punishment introduction. (C) Log latency to complete trials after the VI schedule has elapsed and (D) log latency to initiate responding after receiving punishment and reward. Data presented as mean ± SEM, *P ≤ 0.05, **P ≤ 0.01, aP = 0.068.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537445&req=5

BHU102F4: Depletion of 5-HT in the amygdala or OFC abolishes punishment-induced suppression but leaves intact sensitivity to aversive outcomes. (A) Total responses made by 5-HT amygdala- and OFC-depleted animals and sham-operated controls before (open bars) and after (hatched bars) the introduction of punishment. (B) Change in responding after punishment introduction. (C) Log latency to complete trials after the VI schedule has elapsed and (D) log latency to initiate responding after receiving punishment and reward. Data presented as mean ± SEM, *P ≤ 0.05, **P ≤ 0.01, aP = 0.068.
Mentions: Upon completion of the probabilistic discrimination and reversal stages and following in vivo microdialysis, the sensitivity of all animals to punishment was assessed. Using a VI schedule of reinforcement (20 s) that provided equal opportunities for reward delivery on both sides of the touch screen, experimental groups did not differ in their total number of responses for reward only (Fig. 4A). In contrast, upon introduction of the 40-s VI punishment schedule, with equal frequency of aversive loud noise (0.3-s duration, 108 dB) on both sides, the response suppression that occurred in the controls was not seen in either of the 5-HT-depleted groups (Fig. 4A,B). Indeed, both depleted groups increased their total number of responses during the punishment phase compared with the reward-only phase.Figure 4.

Bottom Line: To address this apparent discrepancy, the present study determined whether both effects could be found in the same animals by performing localized 5-HT depletions in the amygdala or orbitofrontal cortex (OFC) of a New World monkey, the common marmoset. 5-HT depletion in the amygdala impaired response choice on a probabilistic visual discrimination task by increasing the effectiveness of misleading, or false, punishment and reward, and decreased response suppression in a variable interval test of punishment sensitivity that employed the same reward and punisher. 5-HT depletion in the OFC also disrupted probabilistic discrimination learning and decreased response suppression.Computational modeling of behavior on the discrimination task showed that the lesions reduced reinforcement sensitivity.A novel, unitary account of the findings in terms of the causal role of 5-HT in the anticipation of both negative and positive motivational outcomes is proposed and discussed in relation to current theories of 5-HT function and our understanding of mood and anxiety disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Current Address: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neurobiology and Drug Development, Institute of Pharmacology Polish Academy of Sciences, ul Smetna 12, 31-343 Krakow, Poland.

No MeSH data available.


Related in: MedlinePlus