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Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

Rygula R, Clarke HF, Cardinal RN, Cockcroft GJ, Xia J, Dalley JW, Robbins TW, Roberts AC - Cereb. Cortex (2014)

Bottom Line: To address this apparent discrepancy, the present study determined whether both effects could be found in the same animals by performing localized 5-HT depletions in the amygdala or orbitofrontal cortex (OFC) of a New World monkey, the common marmoset. 5-HT depletion in the amygdala impaired response choice on a probabilistic visual discrimination task by increasing the effectiveness of misleading, or false, punishment and reward, and decreased response suppression in a variable interval test of punishment sensitivity that employed the same reward and punisher. 5-HT depletion in the OFC also disrupted probabilistic discrimination learning and decreased response suppression.Computational modeling of behavior on the discrimination task showed that the lesions reduced reinforcement sensitivity.A novel, unitary account of the findings in terms of the causal role of 5-HT in the anticipation of both negative and positive motivational outcomes is proposed and discussed in relation to current theories of 5-HT function and our understanding of mood and anxiety disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Current Address: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neurobiology and Drug Development, Institute of Pharmacology Polish Academy of Sciences, ul Smetna 12, 31-343 Krakow, Poland.

No MeSH data available.


Related in: MedlinePlus

Probabilistic discrimination task. Illustrations of the stimuli used for each discrimination problem. D4 was performed immediately prior to surgery while all the other discriminations, including D4 retention, were performed after surgery.
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BHU102F1: Probabilistic discrimination task. Illustrations of the stimuli used for each discrimination problem. D4 was performed immediately prior to surgery while all the other discriminations, including D4 retention, were performed after surgery.

Mentions: Marmosets were presented with 4 probabilistic discriminations using a different pair of visual stimuli for each. During the first 3 discriminations, the probability was gradually changed, from 0.9 (discrimination 1), through 0.85 (discrimination 2) to 0.8 (discrimination 3). During these early stages, the mildly aversive loud noise was presented at a reduced intensity of 80 dB. After reaching criterion on the third discrimination, animals were maintained on this discrimination, while the noise intensity was gradually increased from 80 to 108 dB. This resulted in a decline in performance in some animals and so all animals were maintained on this discrimination until they had regained criterion. After the fourth and final presurgery discrimination (new pair of stimuli, probability level 0.8, and aversive 108 dB noise; Fig. 1, “D4”), monkeys received 5,7-DHT lesions of the amygdala, OFC, or a sham control procedure.Figure 1.


Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

Rygula R, Clarke HF, Cardinal RN, Cockcroft GJ, Xia J, Dalley JW, Robbins TW, Roberts AC - Cereb. Cortex (2014)

Probabilistic discrimination task. Illustrations of the stimuli used for each discrimination problem. D4 was performed immediately prior to surgery while all the other discriminations, including D4 retention, were performed after surgery.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537445&req=5

BHU102F1: Probabilistic discrimination task. Illustrations of the stimuli used for each discrimination problem. D4 was performed immediately prior to surgery while all the other discriminations, including D4 retention, were performed after surgery.
Mentions: Marmosets were presented with 4 probabilistic discriminations using a different pair of visual stimuli for each. During the first 3 discriminations, the probability was gradually changed, from 0.9 (discrimination 1), through 0.85 (discrimination 2) to 0.8 (discrimination 3). During these early stages, the mildly aversive loud noise was presented at a reduced intensity of 80 dB. After reaching criterion on the third discrimination, animals were maintained on this discrimination, while the noise intensity was gradually increased from 80 to 108 dB. This resulted in a decline in performance in some animals and so all animals were maintained on this discrimination until they had regained criterion. After the fourth and final presurgery discrimination (new pair of stimuli, probability level 0.8, and aversive 108 dB noise; Fig. 1, “D4”), monkeys received 5,7-DHT lesions of the amygdala, OFC, or a sham control procedure.Figure 1.

Bottom Line: To address this apparent discrepancy, the present study determined whether both effects could be found in the same animals by performing localized 5-HT depletions in the amygdala or orbitofrontal cortex (OFC) of a New World monkey, the common marmoset. 5-HT depletion in the amygdala impaired response choice on a probabilistic visual discrimination task by increasing the effectiveness of misleading, or false, punishment and reward, and decreased response suppression in a variable interval test of punishment sensitivity that employed the same reward and punisher. 5-HT depletion in the OFC also disrupted probabilistic discrimination learning and decreased response suppression.Computational modeling of behavior on the discrimination task showed that the lesions reduced reinforcement sensitivity.A novel, unitary account of the findings in terms of the causal role of 5-HT in the anticipation of both negative and positive motivational outcomes is proposed and discussed in relation to current theories of 5-HT function and our understanding of mood and anxiety disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK Current Address: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neurobiology and Drug Development, Institute of Pharmacology Polish Academy of Sciences, ul Smetna 12, 31-343 Krakow, Poland.

No MeSH data available.


Related in: MedlinePlus