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The Neonatal Connectome During Preterm Brain Development.

van den Heuvel MP, Kersbergen KJ, de Reus MA, Keunen K, Kahn RS, Groenendaal F, de Vries LS, Benders MJ - Cereb. Cortex (2014)

Bottom Line: The human connectome is the result of an elaborate developmental trajectory.Analysis of brain development between week 30 and week 40 GA revealed clear developmental effects in neonatal connectome architecture, including a significant increase in white matter microstructure (P < 0.01), small-world topology (P < 0.01) and interhemispheric FC (P < 0.01).Taken together, we conclude that hallmark organizational structures of the human connectome are present before term birth and subject to early development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands Brain Center Rudolf Magnus, The Netherlands.

No MeSH data available.


Development of structural and functional connectivity (a) Panels show individual levels of fractional anisotropy (FA), mean diffusivity (MD) and transverse diffusivity (TD) of each included neonatal dataset in relationship to age. Panels show a clear increase in white matter development between week 30 and week 40 gestational age (GA), illustrated by an increase in FA and a decrease in MD and TD over time. (b) Panel shows individual levels of interhemisperic functional connectivity. (c) Developmental change of structural - functional coupling between week 30 and week 40 GA.
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BHU095F4: Development of structural and functional connectivity (a) Panels show individual levels of fractional anisotropy (FA), mean diffusivity (MD) and transverse diffusivity (TD) of each included neonatal dataset in relationship to age. Panels show a clear increase in white matter development between week 30 and week 40 gestational age (GA), illustrated by an increase in FA and a decrease in MD and TD over time. (b) Panel shows individual levels of interhemisperic functional connectivity. (c) Developmental change of structural - functional coupling between week 30 and week 40 GA.

Mentions: Examination of the white matter markers between week 30 and week 40 postconceptional age revealed changes in prenatal white matter microstructure. First, FA showed a significant increase over time (r = 0.90, P < .001, Fig. 4a), suggesting a development of the local microstructure of the brain's structural connections. Second, other markers of white matter efficacy also showed a clear association with age, including a developmental decrease in the MD (r = 0.88, P < 0.001, Fig. 4a), a decrease in TD coefficient (r = 0.88, P < 0.001, Fig. 4a), and decrease in the PD coefficient (r = 0.82, P < 0.001). As the age range was not normally distributed, additional statistical testing was performed to verify the significance of these findings: Directly testing group differences on FA, MD, TD, and PD between the group of 30-week GA neonates (<32 GA) and the group of 40-week GA neonates (>38 GA) using nonparametric permutation testing of the 2 group means all revealed significant differences between week 30 GA and week 40 GA neonates (P < 0.001, 10 000 permutations). (All tests survived Bonferroni correction for multiple testing).Figure 4.


The Neonatal Connectome During Preterm Brain Development.

van den Heuvel MP, Kersbergen KJ, de Reus MA, Keunen K, Kahn RS, Groenendaal F, de Vries LS, Benders MJ - Cereb. Cortex (2014)

Development of structural and functional connectivity (a) Panels show individual levels of fractional anisotropy (FA), mean diffusivity (MD) and transverse diffusivity (TD) of each included neonatal dataset in relationship to age. Panels show a clear increase in white matter development between week 30 and week 40 gestational age (GA), illustrated by an increase in FA and a decrease in MD and TD over time. (b) Panel shows individual levels of interhemisperic functional connectivity. (c) Developmental change of structural - functional coupling between week 30 and week 40 GA.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

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BHU095F4: Development of structural and functional connectivity (a) Panels show individual levels of fractional anisotropy (FA), mean diffusivity (MD) and transverse diffusivity (TD) of each included neonatal dataset in relationship to age. Panels show a clear increase in white matter development between week 30 and week 40 gestational age (GA), illustrated by an increase in FA and a decrease in MD and TD over time. (b) Panel shows individual levels of interhemisperic functional connectivity. (c) Developmental change of structural - functional coupling between week 30 and week 40 GA.
Mentions: Examination of the white matter markers between week 30 and week 40 postconceptional age revealed changes in prenatal white matter microstructure. First, FA showed a significant increase over time (r = 0.90, P < .001, Fig. 4a), suggesting a development of the local microstructure of the brain's structural connections. Second, other markers of white matter efficacy also showed a clear association with age, including a developmental decrease in the MD (r = 0.88, P < 0.001, Fig. 4a), a decrease in TD coefficient (r = 0.88, P < 0.001, Fig. 4a), and decrease in the PD coefficient (r = 0.82, P < 0.001). As the age range was not normally distributed, additional statistical testing was performed to verify the significance of these findings: Directly testing group differences on FA, MD, TD, and PD between the group of 30-week GA neonates (<32 GA) and the group of 40-week GA neonates (>38 GA) using nonparametric permutation testing of the 2 group means all revealed significant differences between week 30 GA and week 40 GA neonates (P < 0.001, 10 000 permutations). (All tests survived Bonferroni correction for multiple testing).Figure 4.

Bottom Line: The human connectome is the result of an elaborate developmental trajectory.Analysis of brain development between week 30 and week 40 GA revealed clear developmental effects in neonatal connectome architecture, including a significant increase in white matter microstructure (P < 0.01), small-world topology (P < 0.01) and interhemispheric FC (P < 0.01).Taken together, we conclude that hallmark organizational structures of the human connectome are present before term birth and subject to early development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands Brain Center Rudolf Magnus, The Netherlands.

No MeSH data available.