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The Neonatal Connectome During Preterm Brain Development.

van den Heuvel MP, Kersbergen KJ, de Reus MA, Keunen K, Kahn RS, Groenendaal F, de Vries LS, Benders MJ - Cereb. Cortex (2014)

Bottom Line: The human connectome is the result of an elaborate developmental trajectory.Analysis of brain development between week 30 and week 40 GA revealed clear developmental effects in neonatal connectome architecture, including a significant increase in white matter microstructure (P < 0.01), small-world topology (P < 0.01) and interhemispheric FC (P < 0.01).Taken together, we conclude that hallmark organizational structures of the human connectome are present before term birth and subject to early development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands Brain Center Rudolf Magnus, The Netherlands.

No MeSH data available.


Structural and functional connectivity matrices of the neonatal connectome. Figure shows the structural and functional connectivity matrices of the group-averaged neonatal brain. Rows and columns include all cortical regions, expressing the level of structural and functional connections between each pair of regions in the neonatal brain. The structural connectivity matrix (SC) is shown in the left panel, with the levels of connectivity expressed as the number of reconstructed streamlines (NOS) between each pair of regions. Higher levels of SC are indicated by larger dots. Levels of positive functional coupling (i.e., functional connectivity, higher levels of FC are indicated by larger dots) between each pair of regions are shown in the functional connectivity (FC) matrix as shown in the right panel. The columns and rows (i.e., nodes of the network) are ordered according to the community assignment as based on community detection on the FC matrix (see Materials and Methods) revealing the existence of 4 functional communities in the neonatal brain. These communities overlapped temporal (auditory regions), occipital (visual regions), central (motor and sensory regions) and frontal cortex. Distribution of the nodes across the cortex are illustrated in the lower panel. Figure illustrates clear overlap between the SC and FC matrix of the neonatal brain, indicating a structural basis of functional connectivity in the neonatal brain. To aid visual comparison between the SC and FC matrices, positive values are shown in the FC matrices with all negative correlations represented as empty cells.
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BHU095F2: Structural and functional connectivity matrices of the neonatal connectome. Figure shows the structural and functional connectivity matrices of the group-averaged neonatal brain. Rows and columns include all cortical regions, expressing the level of structural and functional connections between each pair of regions in the neonatal brain. The structural connectivity matrix (SC) is shown in the left panel, with the levels of connectivity expressed as the number of reconstructed streamlines (NOS) between each pair of regions. Higher levels of SC are indicated by larger dots. Levels of positive functional coupling (i.e., functional connectivity, higher levels of FC are indicated by larger dots) between each pair of regions are shown in the functional connectivity (FC) matrix as shown in the right panel. The columns and rows (i.e., nodes of the network) are ordered according to the community assignment as based on community detection on the FC matrix (see Materials and Methods) revealing the existence of 4 functional communities in the neonatal brain. These communities overlapped temporal (auditory regions), occipital (visual regions), central (motor and sensory regions) and frontal cortex. Distribution of the nodes across the cortex are illustrated in the lower panel. Figure illustrates clear overlap between the SC and FC matrix of the neonatal brain, indicating a structural basis of functional connectivity in the neonatal brain. To aid visual comparison between the SC and FC matrices, positive values are shown in the FC matrices with all negative correlations represented as empty cells.

Mentions: Functional connectivity of the neonatal brain was examined by means of correlation analysis between resting-state fMRI time-series of cortical brain regions. Cortical regions were identical to the nodes of the structural network, allowing for a direct overlap between the structural (SC) and functional (FC) connections of the neonatal brain. Figure 2a shows a side-by-side comparison of the group-averaged FC matrix of the neonates, together with the group-averaged SC matrix. Rows and columns of both the FC and SC matrix are arranged in the same ordering, with the nodes arranged according to FC module participation (Fig. 2b), showing a clear overlap between the neonate's functional and structural connectivity layout.Figure 2.


The Neonatal Connectome During Preterm Brain Development.

van den Heuvel MP, Kersbergen KJ, de Reus MA, Keunen K, Kahn RS, Groenendaal F, de Vries LS, Benders MJ - Cereb. Cortex (2014)

Structural and functional connectivity matrices of the neonatal connectome. Figure shows the structural and functional connectivity matrices of the group-averaged neonatal brain. Rows and columns include all cortical regions, expressing the level of structural and functional connections between each pair of regions in the neonatal brain. The structural connectivity matrix (SC) is shown in the left panel, with the levels of connectivity expressed as the number of reconstructed streamlines (NOS) between each pair of regions. Higher levels of SC are indicated by larger dots. Levels of positive functional coupling (i.e., functional connectivity, higher levels of FC are indicated by larger dots) between each pair of regions are shown in the functional connectivity (FC) matrix as shown in the right panel. The columns and rows (i.e., nodes of the network) are ordered according to the community assignment as based on community detection on the FC matrix (see Materials and Methods) revealing the existence of 4 functional communities in the neonatal brain. These communities overlapped temporal (auditory regions), occipital (visual regions), central (motor and sensory regions) and frontal cortex. Distribution of the nodes across the cortex are illustrated in the lower panel. Figure illustrates clear overlap between the SC and FC matrix of the neonatal brain, indicating a structural basis of functional connectivity in the neonatal brain. To aid visual comparison between the SC and FC matrices, positive values are shown in the FC matrices with all negative correlations represented as empty cells.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4537441&req=5

BHU095F2: Structural and functional connectivity matrices of the neonatal connectome. Figure shows the structural and functional connectivity matrices of the group-averaged neonatal brain. Rows and columns include all cortical regions, expressing the level of structural and functional connections between each pair of regions in the neonatal brain. The structural connectivity matrix (SC) is shown in the left panel, with the levels of connectivity expressed as the number of reconstructed streamlines (NOS) between each pair of regions. Higher levels of SC are indicated by larger dots. Levels of positive functional coupling (i.e., functional connectivity, higher levels of FC are indicated by larger dots) between each pair of regions are shown in the functional connectivity (FC) matrix as shown in the right panel. The columns and rows (i.e., nodes of the network) are ordered according to the community assignment as based on community detection on the FC matrix (see Materials and Methods) revealing the existence of 4 functional communities in the neonatal brain. These communities overlapped temporal (auditory regions), occipital (visual regions), central (motor and sensory regions) and frontal cortex. Distribution of the nodes across the cortex are illustrated in the lower panel. Figure illustrates clear overlap between the SC and FC matrix of the neonatal brain, indicating a structural basis of functional connectivity in the neonatal brain. To aid visual comparison between the SC and FC matrices, positive values are shown in the FC matrices with all negative correlations represented as empty cells.
Mentions: Functional connectivity of the neonatal brain was examined by means of correlation analysis between resting-state fMRI time-series of cortical brain regions. Cortical regions were identical to the nodes of the structural network, allowing for a direct overlap between the structural (SC) and functional (FC) connections of the neonatal brain. Figure 2a shows a side-by-side comparison of the group-averaged FC matrix of the neonates, together with the group-averaged SC matrix. Rows and columns of both the FC and SC matrix are arranged in the same ordering, with the nodes arranged according to FC module participation (Fig. 2b), showing a clear overlap between the neonate's functional and structural connectivity layout.Figure 2.

Bottom Line: The human connectome is the result of an elaborate developmental trajectory.Analysis of brain development between week 30 and week 40 GA revealed clear developmental effects in neonatal connectome architecture, including a significant increase in white matter microstructure (P < 0.01), small-world topology (P < 0.01) and interhemispheric FC (P < 0.01).Taken together, we conclude that hallmark organizational structures of the human connectome are present before term birth and subject to early development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands Brain Center Rudolf Magnus, The Netherlands.

No MeSH data available.