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Coordinated Information Generation and Mental Flexibility: Large-Scale Network Disruption in Children with Autism.

Mišić B, Doesburg SM, Fatima Z, Vidal J, Vakorin VA, Taylor MJ, McIntosh AR - Cereb. Cortex (2014)

Bottom Line: Multivariate partial least-squares analysis revealed 2 distributed networks, operating at fast and slow time scales, that respond completely differently to set shifting in ASD compared with control children, indicating disrupted temporal organization within these networks.When children with ASD engaged these networks, there was no improvement in performance, suggesting that the networks were ineffective in children with ASD.Our data demonstrate that the coordination and temporal organization of large-scale neural assemblies during the performance of cognitive control tasks is disrupted in children with ASD, contributing to executive function deficits in this group.

View Article: PubMed Central - PubMed

Affiliation: Rotman Research Institute, Baycrest Centre, Toronto, Canada Department of Psychology, University of Toronto, Toronto, Canada.

No MeSH data available.


Related in: MedlinePlus

Groups means for MSE and PSD. Group means for both measures are presented for one randomly selected source. Error bars represent the standard error. Top: Group means for the MSE analysis, at 2 time scales. The data suggest a group by condition interaction, which is confirmed by the subsequent PLS analysis. Bottom: Group means for the PSD analysis, at 2 frequencies. The data suggest a group effect, which is confirmed by the subsequent PLS analysis.
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BHU082F3: Groups means for MSE and PSD. Group means for both measures are presented for one randomly selected source. Error bars represent the standard error. Top: Group means for the MSE analysis, at 2 time scales. The data suggest a group by condition interaction, which is confirmed by the subsequent PLS analysis. Bottom: Group means for the PSD analysis, at 2 frequencies. The data suggest a group effect, which is confirmed by the subsequent PLS analysis.

Mentions: Group means for the power spectra suggested a main effect of group (Fig. 3), and this was confirmed by the subsequent PLS analysis (Fig. 4A). The power spectra produced a strong group effect (P = 0.004, accounting for 84.4% of cross-block covariance) (Fig. 4A). Much of the effect was stratified according to classical frequency bands. Compared with typically developing children, children with ASD expressed decreased power in θ (4 Hz), lower β (20 Hz) and γ (40 Hz), and increased power in α (10 Hz) and upper β (25 Hz) (Fig. 4A).


Coordinated Information Generation and Mental Flexibility: Large-Scale Network Disruption in Children with Autism.

Mišić B, Doesburg SM, Fatima Z, Vidal J, Vakorin VA, Taylor MJ, McIntosh AR - Cereb. Cortex (2014)

Groups means for MSE and PSD. Group means for both measures are presented for one randomly selected source. Error bars represent the standard error. Top: Group means for the MSE analysis, at 2 time scales. The data suggest a group by condition interaction, which is confirmed by the subsequent PLS analysis. Bottom: Group means for the PSD analysis, at 2 frequencies. The data suggest a group effect, which is confirmed by the subsequent PLS analysis.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537433&req=5

BHU082F3: Groups means for MSE and PSD. Group means for both measures are presented for one randomly selected source. Error bars represent the standard error. Top: Group means for the MSE analysis, at 2 time scales. The data suggest a group by condition interaction, which is confirmed by the subsequent PLS analysis. Bottom: Group means for the PSD analysis, at 2 frequencies. The data suggest a group effect, which is confirmed by the subsequent PLS analysis.
Mentions: Group means for the power spectra suggested a main effect of group (Fig. 3), and this was confirmed by the subsequent PLS analysis (Fig. 4A). The power spectra produced a strong group effect (P = 0.004, accounting for 84.4% of cross-block covariance) (Fig. 4A). Much of the effect was stratified according to classical frequency bands. Compared with typically developing children, children with ASD expressed decreased power in θ (4 Hz), lower β (20 Hz) and γ (40 Hz), and increased power in α (10 Hz) and upper β (25 Hz) (Fig. 4A).

Bottom Line: Multivariate partial least-squares analysis revealed 2 distributed networks, operating at fast and slow time scales, that respond completely differently to set shifting in ASD compared with control children, indicating disrupted temporal organization within these networks.When children with ASD engaged these networks, there was no improvement in performance, suggesting that the networks were ineffective in children with ASD.Our data demonstrate that the coordination and temporal organization of large-scale neural assemblies during the performance of cognitive control tasks is disrupted in children with ASD, contributing to executive function deficits in this group.

View Article: PubMed Central - PubMed

Affiliation: Rotman Research Institute, Baycrest Centre, Toronto, Canada Department of Psychology, University of Toronto, Toronto, Canada.

No MeSH data available.


Related in: MedlinePlus