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Coordinated Information Generation and Mental Flexibility: Large-Scale Network Disruption in Children with Autism.

Mišić B, Doesburg SM, Fatima Z, Vidal J, Vakorin VA, Taylor MJ, McIntosh AR - Cereb. Cortex (2014)

Bottom Line: Multivariate partial least-squares analysis revealed 2 distributed networks, operating at fast and slow time scales, that respond completely differently to set shifting in ASD compared with control children, indicating disrupted temporal organization within these networks.When children with ASD engaged these networks, there was no improvement in performance, suggesting that the networks were ineffective in children with ASD.Our data demonstrate that the coordination and temporal organization of large-scale neural assemblies during the performance of cognitive control tasks is disrupted in children with ASD, contributing to executive function deficits in this group.

View Article: PubMed Central - PubMed

Affiliation: Rotman Research Institute, Baycrest Centre, Toronto, Canada Department of Psychology, University of Toronto, Toronto, Canada.

No MeSH data available.


Related in: MedlinePlus

Set-shifting task and source grid. (A) In the set-shifting task, participants must match the target stimulus presented at the bottom of the screen to 1 of 2 choice stimuli presented at the top. Within a set of trials, the match is always made on the basis of one dimension (e.g., red if matching by color, or square if matching by shape). A set shift occurs when the matching rule changes. ID shifts are color-to-color or shape-to-shape. ED shifts are color-to-shape or shape-to-color. (B) Source locations are arranged as a uniformly distributed grid.
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BHU082F1: Set-shifting task and source grid. (A) In the set-shifting task, participants must match the target stimulus presented at the bottom of the screen to 1 of 2 choice stimuli presented at the top. Within a set of trials, the match is always made on the basis of one dimension (e.g., red if matching by color, or square if matching by shape). A set shift occurs when the matching rule changes. ID shifts are color-to-color or shape-to-shape. ED shifts are color-to-shape or shape-to-color. (B) Source locations are arranged as a uniformly distributed grid.

Mentions: Participants performed a set-shifting task, in which they were required to make a two-alternative forced-choice by matching 1 of 2 stimuli with a target stimulus, based either on the color or the shape “dimension” of the target (Fig. 1A). Stimuli were 6 geometric shapes in 6 different colors (a total of 36 bi-dimensional compound stimuli) centered on gray squares. Choice stimuli were presented side by side, above the target stimulus. The stimuli were back-projected onto a screen with a black background. A white cross was displayed in the center of the screen between trials.Figure 1.


Coordinated Information Generation and Mental Flexibility: Large-Scale Network Disruption in Children with Autism.

Mišić B, Doesburg SM, Fatima Z, Vidal J, Vakorin VA, Taylor MJ, McIntosh AR - Cereb. Cortex (2014)

Set-shifting task and source grid. (A) In the set-shifting task, participants must match the target stimulus presented at the bottom of the screen to 1 of 2 choice stimuli presented at the top. Within a set of trials, the match is always made on the basis of one dimension (e.g., red if matching by color, or square if matching by shape). A set shift occurs when the matching rule changes. ID shifts are color-to-color or shape-to-shape. ED shifts are color-to-shape or shape-to-color. (B) Source locations are arranged as a uniformly distributed grid.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537433&req=5

BHU082F1: Set-shifting task and source grid. (A) In the set-shifting task, participants must match the target stimulus presented at the bottom of the screen to 1 of 2 choice stimuli presented at the top. Within a set of trials, the match is always made on the basis of one dimension (e.g., red if matching by color, or square if matching by shape). A set shift occurs when the matching rule changes. ID shifts are color-to-color or shape-to-shape. ED shifts are color-to-shape or shape-to-color. (B) Source locations are arranged as a uniformly distributed grid.
Mentions: Participants performed a set-shifting task, in which they were required to make a two-alternative forced-choice by matching 1 of 2 stimuli with a target stimulus, based either on the color or the shape “dimension” of the target (Fig. 1A). Stimuli were 6 geometric shapes in 6 different colors (a total of 36 bi-dimensional compound stimuli) centered on gray squares. Choice stimuli were presented side by side, above the target stimulus. The stimuli were back-projected onto a screen with a black background. A white cross was displayed in the center of the screen between trials.Figure 1.

Bottom Line: Multivariate partial least-squares analysis revealed 2 distributed networks, operating at fast and slow time scales, that respond completely differently to set shifting in ASD compared with control children, indicating disrupted temporal organization within these networks.When children with ASD engaged these networks, there was no improvement in performance, suggesting that the networks were ineffective in children with ASD.Our data demonstrate that the coordination and temporal organization of large-scale neural assemblies during the performance of cognitive control tasks is disrupted in children with ASD, contributing to executive function deficits in this group.

View Article: PubMed Central - PubMed

Affiliation: Rotman Research Institute, Baycrest Centre, Toronto, Canada Department of Psychology, University of Toronto, Toronto, Canada.

No MeSH data available.


Related in: MedlinePlus