Limits...
Persistence of Functional Sensory Maps in the Absence of Cortical Layers in the Somsatosensory Cortex of Reeler Mice.

Guy J, Wagener RJ, Möck M, Staiger JF - Cereb. Cortex (2014)

Bottom Line: We found that the loss of cortical layers in reeler mice had surprisingly little incidence on these properties.Because intrinsic imaging measures hemodynamic signals, we furthermore investigated the cortical blood vessel pattern of both genotypes, where we also did not detect major differences.In summary, the loss of the reelin protein results in a widespread disturbance of cortical development which compromises neither the establishment nor the function of an ordered, somatotopic map of the facial whiskers.

View Article: PubMed Central - PubMed

Affiliation: Institut für Neuroanatomie, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen D-37075, Germany julien.guy@med.uni-goettingen.de.

No MeSH data available.


Vascular network in the barrel cortex of WT and reeler mice. (A and B) Coronal sections through the somatosensory cortex of 2 representative WT and reeler mice, respectively (n = 6 in each group). DAB staining was used to stain erythrocytes in an unperfused brain, providing an indirect but efficient way of revealing the vascular network of the somatosensory cortex. wm: white matter. Scale bar: 100 μm. (C) Relative density of blood vessels as a function of depth in WT (left) and reeler (right) animals. Density was calculated in 100 μm bins from the pia to the white matter. The first 100 μm below the pia were excluded because a heightened background was consistently found near the pia.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4537421&req=5

BHU052F5: Vascular network in the barrel cortex of WT and reeler mice. (A and B) Coronal sections through the somatosensory cortex of 2 representative WT and reeler mice, respectively (n = 6 in each group). DAB staining was used to stain erythrocytes in an unperfused brain, providing an indirect but efficient way of revealing the vascular network of the somatosensory cortex. wm: white matter. Scale bar: 100 μm. (C) Relative density of blood vessels as a function of depth in WT (left) and reeler (right) animals. Density was calculated in 100 μm bins from the pia to the white matter. The first 100 μm below the pia were excluded because a heightened background was consistently found near the pia.

Mentions: An additional 6 B6C3Fe WT and 6 B6C3Fe reeler were used in a further series of experiments where we sought to label the blood vessels in the barrel cortex (see below and Fig. 5).Figure 2.


Persistence of Functional Sensory Maps in the Absence of Cortical Layers in the Somsatosensory Cortex of Reeler Mice.

Guy J, Wagener RJ, Möck M, Staiger JF - Cereb. Cortex (2014)

Vascular network in the barrel cortex of WT and reeler mice. (A and B) Coronal sections through the somatosensory cortex of 2 representative WT and reeler mice, respectively (n = 6 in each group). DAB staining was used to stain erythrocytes in an unperfused brain, providing an indirect but efficient way of revealing the vascular network of the somatosensory cortex. wm: white matter. Scale bar: 100 μm. (C) Relative density of blood vessels as a function of depth in WT (left) and reeler (right) animals. Density was calculated in 100 μm bins from the pia to the white matter. The first 100 μm below the pia were excluded because a heightened background was consistently found near the pia.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537421&req=5

BHU052F5: Vascular network in the barrel cortex of WT and reeler mice. (A and B) Coronal sections through the somatosensory cortex of 2 representative WT and reeler mice, respectively (n = 6 in each group). DAB staining was used to stain erythrocytes in an unperfused brain, providing an indirect but efficient way of revealing the vascular network of the somatosensory cortex. wm: white matter. Scale bar: 100 μm. (C) Relative density of blood vessels as a function of depth in WT (left) and reeler (right) animals. Density was calculated in 100 μm bins from the pia to the white matter. The first 100 μm below the pia were excluded because a heightened background was consistently found near the pia.
Mentions: An additional 6 B6C3Fe WT and 6 B6C3Fe reeler were used in a further series of experiments where we sought to label the blood vessels in the barrel cortex (see below and Fig. 5).Figure 2.

Bottom Line: We found that the loss of cortical layers in reeler mice had surprisingly little incidence on these properties.Because intrinsic imaging measures hemodynamic signals, we furthermore investigated the cortical blood vessel pattern of both genotypes, where we also did not detect major differences.In summary, the loss of the reelin protein results in a widespread disturbance of cortical development which compromises neither the establishment nor the function of an ordered, somatotopic map of the facial whiskers.

View Article: PubMed Central - PubMed

Affiliation: Institut für Neuroanatomie, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen D-37075, Germany julien.guy@med.uni-goettingen.de.

No MeSH data available.