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Persistence of Functional Sensory Maps in the Absence of Cortical Layers in the Somsatosensory Cortex of Reeler Mice.

Guy J, Wagener RJ, Möck M, Staiger JF - Cereb. Cortex (2014)

Bottom Line: We found that the loss of cortical layers in reeler mice had surprisingly little incidence on these properties.Because intrinsic imaging measures hemodynamic signals, we furthermore investigated the cortical blood vessel pattern of both genotypes, where we also did not detect major differences.In summary, the loss of the reelin protein results in a widespread disturbance of cortical development which compromises neither the establishment nor the function of an ordered, somatotopic map of the facial whiskers.

View Article: PubMed Central - PubMed

Affiliation: Institut für Neuroanatomie, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen D-37075, Germany julien.guy@med.uni-goettingen.de.

No MeSH data available.


Related in: MedlinePlus

Stimulus representation in WT and reeler mice. (A) Top, representation of whisker C2 overlaid with threshold isolines. The level of subsequent thresholds is indicated on the scale bar, which represents fractional change in reflectance. The asterisk labels the peak amplitude of the evoked response. Bottom, same data as top in absolute value. (B) Peak amplitude of evoked response (in fractional change in reflectance, absolute value) as a function of stimulation frequency (mean ± standard error of mean [SEM], n.s.: nonsignificant, ANOVA, P = 0.71). (C) Area encompassed within isolines of thresholds indicated in A as a function of stimulation frequency (in mm2, mean ± SEM, n.s.: nonsignificant, ANOVA, P = 0.12, P = 0.09, and P = 0.35 for 5, 10, and 25 Hz, respectively). The 1 Hz stimulation frequency did not evoke responses that consistently reached threshold values and is therefore not represented here. N = 11 WT and 12 reeler.
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BHU052F4: Stimulus representation in WT and reeler mice. (A) Top, representation of whisker C2 overlaid with threshold isolines. The level of subsequent thresholds is indicated on the scale bar, which represents fractional change in reflectance. The asterisk labels the peak amplitude of the evoked response. Bottom, same data as top in absolute value. (B) Peak amplitude of evoked response (in fractional change in reflectance, absolute value) as a function of stimulation frequency (mean ± standard error of mean [SEM], n.s.: nonsignificant, ANOVA, P = 0.71). (C) Area encompassed within isolines of thresholds indicated in A as a function of stimulation frequency (in mm2, mean ± SEM, n.s.: nonsignificant, ANOVA, P = 0.12, P = 0.09, and P = 0.35 for 5, 10, and 25 Hz, respectively). The 1 Hz stimulation frequency did not evoke responses that consistently reached threshold values and is therefore not represented here. N = 11 WT and 12 reeler.

Mentions: In a second set of experiments, we determined the mean amplitude and area of intrinsic signals evoked by stimulating whisker C2 at different, discrete frequencies (see below and Fig. 4). These experiments were conducted on 11 B6C3Fe WT and 12 B6C3Fe reeler animals, all adults over 3 months of age and of either gender.Figure 1.


Persistence of Functional Sensory Maps in the Absence of Cortical Layers in the Somsatosensory Cortex of Reeler Mice.

Guy J, Wagener RJ, Möck M, Staiger JF - Cereb. Cortex (2014)

Stimulus representation in WT and reeler mice. (A) Top, representation of whisker C2 overlaid with threshold isolines. The level of subsequent thresholds is indicated on the scale bar, which represents fractional change in reflectance. The asterisk labels the peak amplitude of the evoked response. Bottom, same data as top in absolute value. (B) Peak amplitude of evoked response (in fractional change in reflectance, absolute value) as a function of stimulation frequency (mean ± standard error of mean [SEM], n.s.: nonsignificant, ANOVA, P = 0.71). (C) Area encompassed within isolines of thresholds indicated in A as a function of stimulation frequency (in mm2, mean ± SEM, n.s.: nonsignificant, ANOVA, P = 0.12, P = 0.09, and P = 0.35 for 5, 10, and 25 Hz, respectively). The 1 Hz stimulation frequency did not evoke responses that consistently reached threshold values and is therefore not represented here. N = 11 WT and 12 reeler.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4537421&req=5

BHU052F4: Stimulus representation in WT and reeler mice. (A) Top, representation of whisker C2 overlaid with threshold isolines. The level of subsequent thresholds is indicated on the scale bar, which represents fractional change in reflectance. The asterisk labels the peak amplitude of the evoked response. Bottom, same data as top in absolute value. (B) Peak amplitude of evoked response (in fractional change in reflectance, absolute value) as a function of stimulation frequency (mean ± standard error of mean [SEM], n.s.: nonsignificant, ANOVA, P = 0.71). (C) Area encompassed within isolines of thresholds indicated in A as a function of stimulation frequency (in mm2, mean ± SEM, n.s.: nonsignificant, ANOVA, P = 0.12, P = 0.09, and P = 0.35 for 5, 10, and 25 Hz, respectively). The 1 Hz stimulation frequency did not evoke responses that consistently reached threshold values and is therefore not represented here. N = 11 WT and 12 reeler.
Mentions: In a second set of experiments, we determined the mean amplitude and area of intrinsic signals evoked by stimulating whisker C2 at different, discrete frequencies (see below and Fig. 4). These experiments were conducted on 11 B6C3Fe WT and 12 B6C3Fe reeler animals, all adults over 3 months of age and of either gender.Figure 1.

Bottom Line: We found that the loss of cortical layers in reeler mice had surprisingly little incidence on these properties.Because intrinsic imaging measures hemodynamic signals, we furthermore investigated the cortical blood vessel pattern of both genotypes, where we also did not detect major differences.In summary, the loss of the reelin protein results in a widespread disturbance of cortical development which compromises neither the establishment nor the function of an ordered, somatotopic map of the facial whiskers.

View Article: PubMed Central - PubMed

Affiliation: Institut für Neuroanatomie, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen D-37075, Germany julien.guy@med.uni-goettingen.de.

No MeSH data available.


Related in: MedlinePlus