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Merino and Merino-derived sheep breeds: a genome-wide intercontinental study.

Ciani E, Lasagna E, D'Andrea M, Alloggio I, Marroni F, Ceccobelli S, Delgado Bermejo JV, Sarti FM, Kijas J, Lenstra JA, Pilla F, International Sheep Genomics Consorti - Genet. Sel. Evol. (2015)

Bottom Line: The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors.We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Bioscienze, Biotecnologie, Biofarmaceutica, Università degli Studi di Bari "Aldo Moro", Via Amendola 165/A 70126, Bari, Italy. elena.ciani@uniba.it.

ABSTRACT

Background: Merino and Merino-derived sheep breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic sheep breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of breeds from the Sheep HapMap dataset.

Results: Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild sheep, mouflon, primitive North European breeds and modern sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic breeds, with subclusters of Merino and Merino-derived breeds, other Spanish breeds and other Italian breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.

Conclusions: Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived breeds. To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

No MeSH data available.


Related in: MedlinePlus

Neighbor-network of Reynolds’ distances
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Fig4: Neighbor-network of Reynolds’ distances

Mentions: Neighbor-network graphs account for gene flow among breeds (reticulation) and, thus provide a more plausible reconstruction than linear representations. The Neighbor-network clearly separated the wild, feral and primitive North European sheep from modern domestic sheep (Fig. 4). Among these, clear sub-branches were observed that included (i) the Italian Appenninica, Massese, Laticauda, Leccese, Comisana and Sardinian White breeds and (ii) the four Spanish non-Merino breeds (Castellana, Churra, Ojalada and Rasa Aragonesa). The remaining breeds clustered with the group of Merino and Merino-derived breeds. It should be noted that the Spanish Merino from Andalusia occupies a central position between these two sub-branches close to the Spanish non-Merino breeds, while the Estremadura Merino is integrated in the Merino cluster.Fig. 4


Merino and Merino-derived sheep breeds: a genome-wide intercontinental study.

Ciani E, Lasagna E, D'Andrea M, Alloggio I, Marroni F, Ceccobelli S, Delgado Bermejo JV, Sarti FM, Kijas J, Lenstra JA, Pilla F, International Sheep Genomics Consorti - Genet. Sel. Evol. (2015)

Neighbor-network of Reynolds’ distances
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4536749&req=5

Fig4: Neighbor-network of Reynolds’ distances
Mentions: Neighbor-network graphs account for gene flow among breeds (reticulation) and, thus provide a more plausible reconstruction than linear representations. The Neighbor-network clearly separated the wild, feral and primitive North European sheep from modern domestic sheep (Fig. 4). Among these, clear sub-branches were observed that included (i) the Italian Appenninica, Massese, Laticauda, Leccese, Comisana and Sardinian White breeds and (ii) the four Spanish non-Merino breeds (Castellana, Churra, Ojalada and Rasa Aragonesa). The remaining breeds clustered with the group of Merino and Merino-derived breeds. It should be noted that the Spanish Merino from Andalusia occupies a central position between these two sub-branches close to the Spanish non-Merino breeds, while the Estremadura Merino is integrated in the Merino cluster.Fig. 4

Bottom Line: The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors.We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Bioscienze, Biotecnologie, Biofarmaceutica, Università degli Studi di Bari "Aldo Moro", Via Amendola 165/A 70126, Bari, Italy. elena.ciani@uniba.it.

ABSTRACT

Background: Merino and Merino-derived sheep breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic sheep breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of breeds from the Sheep HapMap dataset.

Results: Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild sheep, mouflon, primitive North European breeds and modern sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic breeds, with subclusters of Merino and Merino-derived breeds, other Spanish breeds and other Italian breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.

Conclusions: Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived breeds. To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

No MeSH data available.


Related in: MedlinePlus