Limits...
Merino and Merino-derived sheep breeds: a genome-wide intercontinental study.

Ciani E, Lasagna E, D'Andrea M, Alloggio I, Marroni F, Ceccobelli S, Delgado Bermejo JV, Sarti FM, Kijas J, Lenstra JA, Pilla F, International Sheep Genomics Consorti - Genet. Sel. Evol. (2015)

Bottom Line: The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors.We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Bioscienze, Biotecnologie, Biofarmaceutica, Università degli Studi di Bari "Aldo Moro", Via Amendola 165/A 70126, Bari, Italy. elena.ciani@uniba.it.

ABSTRACT

Background: Merino and Merino-derived sheep breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic sheep breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of breeds from the Sheep HapMap dataset.

Results: Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild sheep, mouflon, primitive North European breeds and modern sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic breeds, with subclusters of Merino and Merino-derived breeds, other Spanish breeds and other Italian breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.

Conclusions: Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived breeds. To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

No MeSH data available.


Related in: MedlinePlus

a MDS plot of the pair-wise IBS distances among samples that belong to the 37 populations considered. Color codes indicate the four groups to which animals were a priori assigned. b Position of breeds along the first dimension (x-axis) of the MDS plot of the pair-wise IBS distances after zooming on the modern breeds
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4536749&req=5

Fig2: a MDS plot of the pair-wise IBS distances among samples that belong to the 37 populations considered. Color codes indicate the four groups to which animals were a priori assigned. b Position of breeds along the first dimension (x-axis) of the MDS plot of the pair-wise IBS distances after zooming on the modern breeds

Mentions: The MDS plot of the pair-wise IBS distances is in Fig. 2a. A clear gradient along the first dimension was observed, which separated wild and feral sheep (right side) from domestic (left side) sheep. Accordingly, animals that originated from primitive north-European breeds occupied an intermediate position along the x-axis. Interestingly, wild and feral individuals were more scattered than their domestic counterparts. Spanish Merino sheep were also more scattered over the plot than other domestic breeds (data not shown).Fig. 2


Merino and Merino-derived sheep breeds: a genome-wide intercontinental study.

Ciani E, Lasagna E, D'Andrea M, Alloggio I, Marroni F, Ceccobelli S, Delgado Bermejo JV, Sarti FM, Kijas J, Lenstra JA, Pilla F, International Sheep Genomics Consorti - Genet. Sel. Evol. (2015)

a MDS plot of the pair-wise IBS distances among samples that belong to the 37 populations considered. Color codes indicate the four groups to which animals were a priori assigned. b Position of breeds along the first dimension (x-axis) of the MDS plot of the pair-wise IBS distances after zooming on the modern breeds
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4536749&req=5

Fig2: a MDS plot of the pair-wise IBS distances among samples that belong to the 37 populations considered. Color codes indicate the four groups to which animals were a priori assigned. b Position of breeds along the first dimension (x-axis) of the MDS plot of the pair-wise IBS distances after zooming on the modern breeds
Mentions: The MDS plot of the pair-wise IBS distances is in Fig. 2a. A clear gradient along the first dimension was observed, which separated wild and feral sheep (right side) from domestic (left side) sheep. Accordingly, animals that originated from primitive north-European breeds occupied an intermediate position along the x-axis. Interestingly, wild and feral individuals were more scattered than their domestic counterparts. Spanish Merino sheep were also more scattered over the plot than other domestic breeds (data not shown).Fig. 2

Bottom Line: The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors.We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Bioscienze, Biotecnologie, Biofarmaceutica, Università degli Studi di Bari "Aldo Moro", Via Amendola 165/A 70126, Bari, Italy. elena.ciani@uniba.it.

ABSTRACT

Background: Merino and Merino-derived sheep breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic sheep breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of breeds from the Sheep HapMap dataset.

Results: Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild sheep, mouflon, primitive North European breeds and modern sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic breeds, with subclusters of Merino and Merino-derived breeds, other Spanish breeds and other Italian breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices.

Conclusions: Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived breeds. To explain how the current Merino and Merino-derived breeds were obtained, we propose a scenario that includes several consecutive migrations of sheep populations that may serve as working hypotheses for subsequent studies.

No MeSH data available.


Related in: MedlinePlus