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Relationship of BMI to the incidence of hypertension: a 4 years' cohort study among children in Guangzhou, 2007-2011.

Wang J, Zhu Y, Jing J, Chen Y, Mai J, Wong SH, O'Reilly J, Ma L - BMC Public Health (2015)

Bottom Line: The thinness was defined by the international age- and gender-specific cut-off points for BMI for thinness grade 1.This study was approved by The Ethical Committee of School of Public Health, Sun Yat-sen University.Additionally, the protective effect of thinness on hypertension was observed in boys 0.808 (0.666, 0.981), but not in girls 1.158 (0.966, 1.389).

View Article: PubMed Central - PubMed

Affiliation: Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, 510080, China. 906796134@qq.com.

ABSTRACT

Background: In China, there has been a dramatic increase in overweight and obesity among children and adolescents in recent decades. However, little longitudinal studies reported BMI in relation to the risk for hypertension among children in China. We examined the longitudinal relations between BMI and hypertension in Chinese schoolchildren via a retrospective cohort study.

Methods: The cohort study was carried out in 7203 children (3821 boys and 3382 girls) in Guangzhou aged 6-8 years, with a continuous 4 years of follow-up. The participants, evaluated by body mass index (BMI), were categorized as thinness, normal weight, overweight, and obesity groups. The age and gender-specific BMI cutoffs newly developed by the Working Group on Obesity in China (WGOC) were used to define overweight and obesity. The thinness was defined by the international age- and gender-specific cut-off points for BMI for thinness grade 1. Hypertension was defined by using percentiles of systolic and diastolic values on the basis of height percentile, age, and gender. The Cox proportional hazards model was used to estimate the single or joint effect of BMI on the risk of hypertension. This study was approved by The Ethical Committee of School of Public Health, Sun Yat-sen University.

Results: During a follow-up of 4 years, a shocking high cumulative incidence of hypertension was found in Chinese overweight (50.1 %) and obesity (70 %) schoolchildren. The incidence of children hypertension were markedly higher among overweight and obesity group than normal weight and thinness group (24.3 %, 18.5 % vs 11.1 %, 7.4 %). Compared with the children in the normal weight group, the adjusted HRs and 95 % CIs of developing hypertension in thinness, overweight, and obesity group were 0.972 (0.851, 1.110), 1.313 (1.179, 1.461), and 1.816 (1.634, 2.081), respectively. Additionally, the protective effect of thinness on hypertension was observed in boys 0.808 (0.666, 0.981), but not in girls 1.158 (0.966, 1.389).

Conclusions: The 4-year longitudinal study indicated that the overweight and obesity can predict the higher risk of hypertension in Chinese children, whereas, the thinness predict the lower risk of hypertension only in boys.

No MeSH data available.


Related in: MedlinePlus

Hazards ratios of hypertension according to different BMI groupsb. a Reference category: normal weight BMI. b The Hazards ratios of the total population were adjusted for age, gender and baseline blood pressure, and those of the boys or girls were adjusted for ages and baseline blood pressure
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Fig2: Hazards ratios of hypertension according to different BMI groupsb. a Reference category: normal weight BMI. b The Hazards ratios of the total population were adjusted for age, gender and baseline blood pressure, and those of the boys or girls were adjusted for ages and baseline blood pressure

Mentions: Cox proportional hazards model results were shown in Fig. 2. After adjustment for age gender and baseline blood pressure, in comparison with normal weight students, the Hazards ratios (HRs) of hypertension was 1.816 (95 % CI 1.634–2.081, P < 0.05) and 1.313 (95 % CI 1.179–1.461, P < 0.05) in obesity and overweight students, respectively, which indicated an increased risk of developing hypertension in the two status. In addition, compared to normal weight students, there was also a slight association between thinness and hypertension with a decreased risk of developing hypertension in boys (adjusted HR = 0.808, 95 % CI = 0.666–0.981, P < 0.05).Fig. 2


Relationship of BMI to the incidence of hypertension: a 4 years' cohort study among children in Guangzhou, 2007-2011.

Wang J, Zhu Y, Jing J, Chen Y, Mai J, Wong SH, O'Reilly J, Ma L - BMC Public Health (2015)

Hazards ratios of hypertension according to different BMI groupsb. a Reference category: normal weight BMI. b The Hazards ratios of the total population were adjusted for age, gender and baseline blood pressure, and those of the boys or girls were adjusted for ages and baseline blood pressure
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4536743&req=5

Fig2: Hazards ratios of hypertension according to different BMI groupsb. a Reference category: normal weight BMI. b The Hazards ratios of the total population were adjusted for age, gender and baseline blood pressure, and those of the boys or girls were adjusted for ages and baseline blood pressure
Mentions: Cox proportional hazards model results were shown in Fig. 2. After adjustment for age gender and baseline blood pressure, in comparison with normal weight students, the Hazards ratios (HRs) of hypertension was 1.816 (95 % CI 1.634–2.081, P < 0.05) and 1.313 (95 % CI 1.179–1.461, P < 0.05) in obesity and overweight students, respectively, which indicated an increased risk of developing hypertension in the two status. In addition, compared to normal weight students, there was also a slight association between thinness and hypertension with a decreased risk of developing hypertension in boys (adjusted HR = 0.808, 95 % CI = 0.666–0.981, P < 0.05).Fig. 2

Bottom Line: The thinness was defined by the international age- and gender-specific cut-off points for BMI for thinness grade 1.This study was approved by The Ethical Committee of School of Public Health, Sun Yat-sen University.Additionally, the protective effect of thinness on hypertension was observed in boys 0.808 (0.666, 0.981), but not in girls 1.158 (0.966, 1.389).

View Article: PubMed Central - PubMed

Affiliation: Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, 510080, China. 906796134@qq.com.

ABSTRACT

Background: In China, there has been a dramatic increase in overweight and obesity among children and adolescents in recent decades. However, little longitudinal studies reported BMI in relation to the risk for hypertension among children in China. We examined the longitudinal relations between BMI and hypertension in Chinese schoolchildren via a retrospective cohort study.

Methods: The cohort study was carried out in 7203 children (3821 boys and 3382 girls) in Guangzhou aged 6-8 years, with a continuous 4 years of follow-up. The participants, evaluated by body mass index (BMI), were categorized as thinness, normal weight, overweight, and obesity groups. The age and gender-specific BMI cutoffs newly developed by the Working Group on Obesity in China (WGOC) were used to define overweight and obesity. The thinness was defined by the international age- and gender-specific cut-off points for BMI for thinness grade 1. Hypertension was defined by using percentiles of systolic and diastolic values on the basis of height percentile, age, and gender. The Cox proportional hazards model was used to estimate the single or joint effect of BMI on the risk of hypertension. This study was approved by The Ethical Committee of School of Public Health, Sun Yat-sen University.

Results: During a follow-up of 4 years, a shocking high cumulative incidence of hypertension was found in Chinese overweight (50.1 %) and obesity (70 %) schoolchildren. The incidence of children hypertension were markedly higher among overweight and obesity group than normal weight and thinness group (24.3 %, 18.5 % vs 11.1 %, 7.4 %). Compared with the children in the normal weight group, the adjusted HRs and 95 % CIs of developing hypertension in thinness, overweight, and obesity group were 0.972 (0.851, 1.110), 1.313 (1.179, 1.461), and 1.816 (1.634, 2.081), respectively. Additionally, the protective effect of thinness on hypertension was observed in boys 0.808 (0.666, 0.981), but not in girls 1.158 (0.966, 1.389).

Conclusions: The 4-year longitudinal study indicated that the overweight and obesity can predict the higher risk of hypertension in Chinese children, whereas, the thinness predict the lower risk of hypertension only in boys.

No MeSH data available.


Related in: MedlinePlus