Limits...
Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years.

Ludwig U, Holzner D, Denzer C, Greinert A, Haenle MM, Oeztuerk S, Koenig W, Boehm BO, Mason RA, Kratzer W, Graeter T, EMIL-Stu - BMC Endocr Disord (2015)

Bottom Line: Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide.After application of exclusion criteria, a total of 1,276 subjects were included in the study collective.The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p =0.0004).

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany. ulla.ludwig@uniklinik-ulm.de.

ABSTRACT

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective of the present study was to investigate the association between thyroid dysfunction and hepatic steatosis.

Methods: Data from 2,445 subjects (51.7% females) aged 18 to 65 years participating in a population-based cross-sectional study were assessed based on a standardized questionnaire and documentation of physical, biochemical and ultrasonographic findings. After application of exclusion criteria, a total of 1,276 subjects were included in the study collective. The influence of potential factors on the development of hepatic steatosis was assessed using multivariate logistic regression.

Results: The prevalence of hepatic steatosis in the study collective was 27.4% (n = 349). The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p =0.0004). Adjusting for age, or BMI, there was an increased prevalence of hepatic steatosis in subjects with reduced TT4 concentrations (p = 0.0143; p = < .0001).

Conclusions: The findings of the present study confirm an association between both subclinical and clinical hypothyroidism and hepatic steatosis.

No MeSH data available.


Related in: MedlinePlus

Flow of the subjects across the study. The base collective for the present study consisted of the 2,445 subjects of the EMIL study. Of these, 258 subjects were excluded due to age < 18 years; 69 due to excessive alcohol consumption (>40 g/day in males and > 20 g/day in females); 146 due to past or current hepatitis B or hepatitis C infections;intake of iodone (n = 344), antithyroid agents (n = 2) or thyroid hormones (n = 437); and 1 due to hemochromatosis. Incomplete data, laboratory values or other data were also exclusion criteria. Each box represents an exclusion criterion and contains the corresponding number of subjects in relation to the total collective. An individual subject may meet multiple exclusion criteria. For the present study, the resulting collective consisted of 1,276 individuals
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4536732&req=5

Fig1: Flow of the subjects across the study. The base collective for the present study consisted of the 2,445 subjects of the EMIL study. Of these, 258 subjects were excluded due to age < 18 years; 69 due to excessive alcohol consumption (>40 g/day in males and > 20 g/day in females); 146 due to past or current hepatitis B or hepatitis C infections;intake of iodone (n = 344), antithyroid agents (n = 2) or thyroid hormones (n = 437); and 1 due to hemochromatosis. Incomplete data, laboratory values or other data were also exclusion criteria. Each box represents an exclusion criterion and contains the corresponding number of subjects in relation to the total collective. An individual subject may meet multiple exclusion criteria. For the present study, the resulting collective consisted of 1,276 individuals

Mentions: A cross-sectional survey assessing the prevalence of EchinococcusMultilocularisInfection and other medical disorders inLeutkirch (EMIL-Study), was conducted in Leutkirch, Germany in 2002. Initially, 4,000 of the total 12,475 residents were randomly selected by the staff of the municipal registry office from the roster of inhabitants. Out of these 4,000 persons, 107 were excluded because their address was unknown or they had not given their informed consent. A total of 2,445 individuals finally participated in the study, corresponding to a participation rate of 62.8 % [19]. Following exclusion of subjects less than 18 years (n = 258) and subjects with incomplete laboratory results (n = 230), those with past or present hepatitis B or hepatitis C virus infections (n = 146), hemochromatosis (n = 1) or elevated alcohol consumption (>40 g/day in males and > 20 g/day in females; n = 69), intake of iodone (n = 344), antithyroid agents (n = 2) or thyroid hormones (n = 437), missing ultrasonographic data on hepatic steatosis (n = 16), missing data on BMI (n = 11) or metabolic syndrome (n = 77), a total of 1,276 subjects were finally included in the present analysis (Fig. 1). This study collective was then divided, based on the diagnosis of NAFLD, into an NAFLD group (n = 349) and a healthy control group (n = 927).Fig. 1


Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years.

Ludwig U, Holzner D, Denzer C, Greinert A, Haenle MM, Oeztuerk S, Koenig W, Boehm BO, Mason RA, Kratzer W, Graeter T, EMIL-Stu - BMC Endocr Disord (2015)

Flow of the subjects across the study. The base collective for the present study consisted of the 2,445 subjects of the EMIL study. Of these, 258 subjects were excluded due to age < 18 years; 69 due to excessive alcohol consumption (>40 g/day in males and > 20 g/day in females); 146 due to past or current hepatitis B or hepatitis C infections;intake of iodone (n = 344), antithyroid agents (n = 2) or thyroid hormones (n = 437); and 1 due to hemochromatosis. Incomplete data, laboratory values or other data were also exclusion criteria. Each box represents an exclusion criterion and contains the corresponding number of subjects in relation to the total collective. An individual subject may meet multiple exclusion criteria. For the present study, the resulting collective consisted of 1,276 individuals
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4536732&req=5

Fig1: Flow of the subjects across the study. The base collective for the present study consisted of the 2,445 subjects of the EMIL study. Of these, 258 subjects were excluded due to age < 18 years; 69 due to excessive alcohol consumption (>40 g/day in males and > 20 g/day in females); 146 due to past or current hepatitis B or hepatitis C infections;intake of iodone (n = 344), antithyroid agents (n = 2) or thyroid hormones (n = 437); and 1 due to hemochromatosis. Incomplete data, laboratory values or other data were also exclusion criteria. Each box represents an exclusion criterion and contains the corresponding number of subjects in relation to the total collective. An individual subject may meet multiple exclusion criteria. For the present study, the resulting collective consisted of 1,276 individuals
Mentions: A cross-sectional survey assessing the prevalence of EchinococcusMultilocularisInfection and other medical disorders inLeutkirch (EMIL-Study), was conducted in Leutkirch, Germany in 2002. Initially, 4,000 of the total 12,475 residents were randomly selected by the staff of the municipal registry office from the roster of inhabitants. Out of these 4,000 persons, 107 were excluded because their address was unknown or they had not given their informed consent. A total of 2,445 individuals finally participated in the study, corresponding to a participation rate of 62.8 % [19]. Following exclusion of subjects less than 18 years (n = 258) and subjects with incomplete laboratory results (n = 230), those with past or present hepatitis B or hepatitis C virus infections (n = 146), hemochromatosis (n = 1) or elevated alcohol consumption (>40 g/day in males and > 20 g/day in females; n = 69), intake of iodone (n = 344), antithyroid agents (n = 2) or thyroid hormones (n = 437), missing ultrasonographic data on hepatic steatosis (n = 16), missing data on BMI (n = 11) or metabolic syndrome (n = 77), a total of 1,276 subjects were finally included in the present analysis (Fig. 1). This study collective was then divided, based on the diagnosis of NAFLD, into an NAFLD group (n = 349) and a healthy control group (n = 927).Fig. 1

Bottom Line: Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide.After application of exclusion criteria, a total of 1,276 subjects were included in the study collective.The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p =0.0004).

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany. ulla.ludwig@uniklinik-ulm.de.

ABSTRACT

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective of the present study was to investigate the association between thyroid dysfunction and hepatic steatosis.

Methods: Data from 2,445 subjects (51.7% females) aged 18 to 65 years participating in a population-based cross-sectional study were assessed based on a standardized questionnaire and documentation of physical, biochemical and ultrasonographic findings. After application of exclusion criteria, a total of 1,276 subjects were included in the study collective. The influence of potential factors on the development of hepatic steatosis was assessed using multivariate logistic regression.

Results: The prevalence of hepatic steatosis in the study collective was 27.4% (n = 349). The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p =0.0004). Adjusting for age, or BMI, there was an increased prevalence of hepatic steatosis in subjects with reduced TT4 concentrations (p = 0.0143; p = < .0001).

Conclusions: The findings of the present study confirm an association between both subclinical and clinical hypothyroidism and hepatic steatosis.

No MeSH data available.


Related in: MedlinePlus