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Occupational asthma caused by nickel and zinc.

Hong CS, Oh SH, Lee HC, Huh KB, Lee SY - Korean J. Intern. Med. (1986)

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ABSTRACT

A 28-year-old man developed asthma 10 years after working in a metal-plating factory. Recordings of peak expiratory flow rates showed increased variations after exposure at work. Allergy prick skin tests elicited an immediate reaction with nickel sulfate at a concentration of 1 and 10 mg/ml, and with zinc sulfate at a concentration of 10 mg/ml. Inhalation challenges with nickel sulfate and zinc sulfate produced bronchial obstructions. Thus, we concluded that this was a case of asthma caused by nickel sulfate and zinc sulfate.

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BPT with nickel sulfate. Eighteen percent fall of FEV1 and 28% fall of FEF25–75% were noted one hour after inhalation of 10 mg/ml solution for three minutes by tidal volume breathing.
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f2-kjim-1-2-259-20: BPT with nickel sulfate. Eighteen percent fall of FEV1 and 28% fall of FEF25–75% were noted one hour after inhalation of 10 mg/ml solution for three minutes by tidal volume breathing.

Mentions: The result of nickel sulfate bronchoprovocation tests are shown in figure 2. Inhalation of normal saline resulted in no significant change of FEV1. Three challenges of 10 mg/ml of nickel sulfate solution (inhaled by FVC breathing 5 times) showed a 10% decrease in FEV1. Four hours later he inhaled a 10 mg/ml solution for 3 minutes by tidal volume breathing. Ten minutes later he felt a mild tightness in his chest and coughed. One hour later, the percentage fall in FEV1 was 18%, and the percentage fall in FEF25–75% was 28%, which demonstrated that pulmonary function had progressively improved. On the morning of the following day, pulmonary function had returned to the initial level.


Occupational asthma caused by nickel and zinc.

Hong CS, Oh SH, Lee HC, Huh KB, Lee SY - Korean J. Intern. Med. (1986)

BPT with nickel sulfate. Eighteen percent fall of FEV1 and 28% fall of FEF25–75% were noted one hour after inhalation of 10 mg/ml solution for three minutes by tidal volume breathing.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4536724&req=5

f2-kjim-1-2-259-20: BPT with nickel sulfate. Eighteen percent fall of FEV1 and 28% fall of FEF25–75% were noted one hour after inhalation of 10 mg/ml solution for three minutes by tidal volume breathing.
Mentions: The result of nickel sulfate bronchoprovocation tests are shown in figure 2. Inhalation of normal saline resulted in no significant change of FEV1. Three challenges of 10 mg/ml of nickel sulfate solution (inhaled by FVC breathing 5 times) showed a 10% decrease in FEV1. Four hours later he inhaled a 10 mg/ml solution for 3 minutes by tidal volume breathing. Ten minutes later he felt a mild tightness in his chest and coughed. One hour later, the percentage fall in FEV1 was 18%, and the percentage fall in FEF25–75% was 28%, which demonstrated that pulmonary function had progressively improved. On the morning of the following day, pulmonary function had returned to the initial level.

View Article: PubMed Central - PubMed

ABSTRACT

A 28-year-old man developed asthma 10 years after working in a metal-plating factory. Recordings of peak expiratory flow rates showed increased variations after exposure at work. Allergy prick skin tests elicited an immediate reaction with nickel sulfate at a concentration of 1 and 10 mg/ml, and with zinc sulfate at a concentration of 10 mg/ml. Inhalation challenges with nickel sulfate and zinc sulfate produced bronchial obstructions. Thus, we concluded that this was a case of asthma caused by nickel sulfate and zinc sulfate.

Show MeSH