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A malignant mixed germ cell tumor originating from the pituitary gland with a suprasellar extension: a case report.

Lim SK, Chung HC, Kim WT, Huh KB, Chung SS, Kim DI, Chung HJ - Korean J. Intern. Med. (1986)

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ABSTRACT

A case of an intracranial tumor in a 26-year old woman with symptoms of hypopituitarism, and visual disturbance is presented. The primary site has been verified by the clinical presentations and the hormonal and the neurological studies as originating from the pituitary gland with extension to the suprasellar area. Histologically, the tumor contains elements that demand its interpretation as a malignant teratoma. In a tumor marker study, the aFP level was elevated, suggestive of an endodermal sinus tumor component. We report this case as a mixed germ cell tumor originating from the pituitary gland with a suprasellar extension and a malignant transformation from a benign component.

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Left: Remnant of intrasetlar and left parasellar mass, following sugery and first course of chemotherapy. Cystic transformation of suprasellar mass can be seen (arrow) Right: Marked shrinkage of left parasellar mass and cystic suprasellar mass with a remnant intrasellar mass, following raditotherapy.
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f3-kjim-1-2-266-22: Left: Remnant of intrasetlar and left parasellar mass, following sugery and first course of chemotherapy. Cystic transformation of suprasellar mass can be seen (arrow) Right: Marked shrinkage of left parasellar mass and cystic suprasellar mass with a remnant intrasellar mass, following raditotherapy.

Mentions: Sixteen days after her first program of chemotherapy, she was readmitted for the second course of chemotherapy. Bilateral hemianopsia had disappeared with an improvement of visual acuity of 20/50 (O.U.). Galactorrhea disappeared, also, but the amenorrhea persisted. Alphafetoprotein became undetectable in the serum and CSF, and there was no elevation on HCG in either. On a follow-up C-T scan, the tumor mass was found to have shrunk (Fig. 3).


A malignant mixed germ cell tumor originating from the pituitary gland with a suprasellar extension: a case report.

Lim SK, Chung HC, Kim WT, Huh KB, Chung SS, Kim DI, Chung HJ - Korean J. Intern. Med. (1986)

Left: Remnant of intrasetlar and left parasellar mass, following sugery and first course of chemotherapy. Cystic transformation of suprasellar mass can be seen (arrow) Right: Marked shrinkage of left parasellar mass and cystic suprasellar mass with a remnant intrasellar mass, following raditotherapy.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4536722&req=5

f3-kjim-1-2-266-22: Left: Remnant of intrasetlar and left parasellar mass, following sugery and first course of chemotherapy. Cystic transformation of suprasellar mass can be seen (arrow) Right: Marked shrinkage of left parasellar mass and cystic suprasellar mass with a remnant intrasellar mass, following raditotherapy.
Mentions: Sixteen days after her first program of chemotherapy, she was readmitted for the second course of chemotherapy. Bilateral hemianopsia had disappeared with an improvement of visual acuity of 20/50 (O.U.). Galactorrhea disappeared, also, but the amenorrhea persisted. Alphafetoprotein became undetectable in the serum and CSF, and there was no elevation on HCG in either. On a follow-up C-T scan, the tumor mass was found to have shrunk (Fig. 3).

View Article: PubMed Central - PubMed

ABSTRACT

A case of an intracranial tumor in a 26-year old woman with symptoms of hypopituitarism, and visual disturbance is presented. The primary site has been verified by the clinical presentations and the hormonal and the neurological studies as originating from the pituitary gland with extension to the suprasellar area. Histologically, the tumor contains elements that demand its interpretation as a malignant teratoma. In a tumor marker study, the aFP level was elevated, suggestive of an endodermal sinus tumor component. We report this case as a mixed germ cell tumor originating from the pituitary gland with a suprasellar extension and a malignant transformation from a benign component.

Show MeSH
Related in: MedlinePlus