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A malignant mixed germ cell tumor originating from the pituitary gland with a suprasellar extension: a case report.

Lim SK, Chung HC, Kim WT, Huh KB, Chung SS, Kim DI, Chung HJ - Korean J. Intern. Med. (1986)

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ABSTRACT

A case of an intracranial tumor in a 26-year old woman with symptoms of hypopituitarism, and visual disturbance is presented. The primary site has been verified by the clinical presentations and the hormonal and the neurological studies as originating from the pituitary gland with extension to the suprasellar area. Histologically, the tumor contains elements that demand its interpretation as a malignant teratoma. In a tumor marker study, the aFP level was elevated, suggestive of an endodermal sinus tumor component. We report this case as a mixed germ cell tumor originating from the pituitary gland with a suprasellar extension and a malignant transformation from a benign component.

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Various tissue components of the teratoma (H & X stain, ×200). (A) Keratin whirl (arrow), squamous epithelium and glandular structure (arrow head). (B) Primitive stromal tissue, neuroectodermal tissue and malignant cells (H & E stain, ×200)
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f2-kjim-1-2-266-22: Various tissue components of the teratoma (H & X stain, ×200). (A) Keratin whirl (arrow), squamous epithelium and glandular structure (arrow head). (B) Primitive stromal tissue, neuroectodermal tissue and malignant cells (H & E stain, ×200)

Mentions: The pituitary fossa was explored through a trans-sphenoidal approaceh. A hard surfaced, encapsulated, somewhat whitish intrasellar mass was removed. Microscopic examination showed neuroectodermal tissue (80%), squamous epithelium, cartilage and skeletal muscle. The neuroectodermal tissue was composed of neuroepithelial elements and mature or anaplastic giant cells (Fig. 2). The post-operative course was complicated by transient diabetes insipidus, and regressive behavior. The follow-up ventricular-evoked potential which was done on the second post-operative day showed improved visual function.


A malignant mixed germ cell tumor originating from the pituitary gland with a suprasellar extension: a case report.

Lim SK, Chung HC, Kim WT, Huh KB, Chung SS, Kim DI, Chung HJ - Korean J. Intern. Med. (1986)

Various tissue components of the teratoma (H & X stain, ×200). (A) Keratin whirl (arrow), squamous epithelium and glandular structure (arrow head). (B) Primitive stromal tissue, neuroectodermal tissue and malignant cells (H & E stain, ×200)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4536722&req=5

f2-kjim-1-2-266-22: Various tissue components of the teratoma (H & X stain, ×200). (A) Keratin whirl (arrow), squamous epithelium and glandular structure (arrow head). (B) Primitive stromal tissue, neuroectodermal tissue and malignant cells (H & E stain, ×200)
Mentions: The pituitary fossa was explored through a trans-sphenoidal approaceh. A hard surfaced, encapsulated, somewhat whitish intrasellar mass was removed. Microscopic examination showed neuroectodermal tissue (80%), squamous epithelium, cartilage and skeletal muscle. The neuroectodermal tissue was composed of neuroepithelial elements and mature or anaplastic giant cells (Fig. 2). The post-operative course was complicated by transient diabetes insipidus, and regressive behavior. The follow-up ventricular-evoked potential which was done on the second post-operative day showed improved visual function.

View Article: PubMed Central - PubMed

ABSTRACT

A case of an intracranial tumor in a 26-year old woman with symptoms of hypopituitarism, and visual disturbance is presented. The primary site has been verified by the clinical presentations and the hormonal and the neurological studies as originating from the pituitary gland with extension to the suprasellar area. Histologically, the tumor contains elements that demand its interpretation as a malignant teratoma. In a tumor marker study, the aFP level was elevated, suggestive of an endodermal sinus tumor component. We report this case as a mixed germ cell tumor originating from the pituitary gland with a suprasellar extension and a malignant transformation from a benign component.

Show MeSH
Related in: MedlinePlus