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Erythrocyte Na(+)-K+ ATPase activity in the genesis of reducing renal mass in hypertensive rats.

Yoon YS, Bang BK, Min BS, Kim HJ - Korean J. Intern. Med. (1986)

View Article: PubMed Central - PubMed

ABSTRACT

The fractional excretion of Na in hypertensive, reduced renal mass rats (saline-drinking) was higher than that of normotensive, reduced renal mass rats (water-drinking) (p<.001). The plasma renin activities in the hypertensive group were markedly lower than those of the normotensive group (p<.001).

The total ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than in those of the normal and the normotensive groups (p<.001, p<.02).

The Mg++-ATPase activities of rat erythrocyte membrane in the normotensive group tended to decrease significantly (p<.001), but the differences between the normotensive and hypertensive group were not significant.

The Na+-K+ ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than those of the normal and the normotensive group (p<.001). However, the difference between the normal and the normotensive groups was not significant.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the total ATPase activities of erythrocyte membrane were not different from those of hypertensive rats.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the Mg++ ATPase activities of erythrocyte membrane were lower than those of hypertensive rats (p<.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p<.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p<.01).

Based on the above findings, it is suggested that the pathogenesis of low renin, reduced renal mass hypertension is primarily mediated by a natriuretic factor (or an ouabain-like factor, inhibitor of Na+-K+ ATPase) produced by extracellular fluid volume expansion.

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The erythrocyte ATPase activities taken from normal rats when incubated in supernates of boiled plasma from control normotensive and experimental hypertensive rats.
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f2-kjim-1-2-185-9: The erythrocyte ATPase activities taken from normal rats when incubated in supernates of boiled plasma from control normotensive and experimental hypertensive rats.

Mentions: The erythrocyte total ATPase activities in the hypertensive group were significantly lowered compared to those of the normotensive group (p<.02), and showed lower values in both groups compared to those in the normal rats which had not had subtotal nephrectomis (p<.001). The erythrocyte Mg++ ATPase activities in both normotensive and hypertensive groups showed no significant difference. The erythrocyte Na+-K+ ATPase activities were significantly lowered in the hypertensive group compared to those of the normotensive group (p<.001), while there was no significant difference between their change in normal rats and the normotensive rats.


Erythrocyte Na(+)-K+ ATPase activity in the genesis of reducing renal mass in hypertensive rats.

Yoon YS, Bang BK, Min BS, Kim HJ - Korean J. Intern. Med. (1986)

The erythrocyte ATPase activities taken from normal rats when incubated in supernates of boiled plasma from control normotensive and experimental hypertensive rats.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4536719&req=5

f2-kjim-1-2-185-9: The erythrocyte ATPase activities taken from normal rats when incubated in supernates of boiled plasma from control normotensive and experimental hypertensive rats.
Mentions: The erythrocyte total ATPase activities in the hypertensive group were significantly lowered compared to those of the normotensive group (p<.02), and showed lower values in both groups compared to those in the normal rats which had not had subtotal nephrectomis (p<.001). The erythrocyte Mg++ ATPase activities in both normotensive and hypertensive groups showed no significant difference. The erythrocyte Na+-K+ ATPase activities were significantly lowered in the hypertensive group compared to those of the normotensive group (p<.001), while there was no significant difference between their change in normal rats and the normotensive rats.

View Article: PubMed Central - PubMed

ABSTRACT

The fractional excretion of Na in hypertensive, reduced renal mass rats (saline-drinking) was higher than that of normotensive, reduced renal mass rats (water-drinking) (p&lt;.001). The plasma renin activities in the hypertensive group were markedly lower than those of the normotensive group (p&lt;.001).

The total ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than in those of the normal and the normotensive groups (p&lt;.001, p&lt;.02).

The Mg++-ATPase activities of rat erythrocyte membrane in the normotensive group tended to decrease significantly (p&lt;.001), but the differences between the normotensive and hypertensive group were not significant.

The Na+-K+ ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than those of the normal and the normotensive group (p&lt;.001). However, the difference between the normal and the normotensive groups was not significant.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the total ATPase activities of erythrocyte membrane were not different from those of hypertensive rats.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the Mg++ ATPase activities of erythrocyte membrane were lower than those of hypertensive rats (p&lt;.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p&lt;.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p&lt;.01).

Based on the above findings, it is suggested that the pathogenesis of low renin, reduced renal mass hypertension is primarily mediated by a natriuretic factor (or an ouabain-like factor, inhibitor of Na+-K+ ATPase) produced by extracellular fluid volume expansion.

Show MeSH