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Erythrocyte Na(+)-K+ ATPase activity in the genesis of reducing renal mass in hypertensive rats.

Yoon YS, Bang BK, Min BS, Kim HJ - Korean J. Intern. Med. (1986)

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ABSTRACT

The fractional excretion of Na in hypertensive, reduced renal mass rats (saline-drinking) was higher than that of normotensive, reduced renal mass rats (water-drinking) (p<.001). The plasma renin activities in the hypertensive group were markedly lower than those of the normotensive group (p<.001).

The total ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than in those of the normal and the normotensive groups (p<.001, p<.02).

The Mg++-ATPase activities of rat erythrocyte membrane in the normotensive group tended to decrease significantly (p<.001), but the differences between the normotensive and hypertensive group were not significant.

The Na+-K+ ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than those of the normal and the normotensive group (p<.001). However, the difference between the normal and the normotensive groups was not significant.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the total ATPase activities of erythrocyte membrane were not different from those of hypertensive rats.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the Mg++ ATPase activities of erythrocyte membrane were lower than those of hypertensive rats (p<.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p<.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p<.01).

Based on the above findings, it is suggested that the pathogenesis of low renin, reduced renal mass hypertension is primarily mediated by a natriuretic factor (or an ouabain-like factor, inhibitor of Na+-K+ ATPase) produced by extracellular fluid volume expansion.

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The erythrocyte ATPase activities in control and experimental groups.
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f1-kjim-1-2-185-9: The erythrocyte ATPase activities in control and experimental groups.

Mentions: Both urine Na and K were significantly increased in the hypertensive group (p<.01, p<.05), while urine creatinine was significantly decreased (p<.05). Particularly, the fractional excretion rate of urine Na, 0.5±0.2% in the normotensive group and 6.6±1.9% in the hypertensive group, showed a magnification factor of about 13 times (p<.005).


Erythrocyte Na(+)-K+ ATPase activity in the genesis of reducing renal mass in hypertensive rats.

Yoon YS, Bang BK, Min BS, Kim HJ - Korean J. Intern. Med. (1986)

The erythrocyte ATPase activities in control and experimental groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4536719&req=5

f1-kjim-1-2-185-9: The erythrocyte ATPase activities in control and experimental groups.
Mentions: Both urine Na and K were significantly increased in the hypertensive group (p<.01, p<.05), while urine creatinine was significantly decreased (p<.05). Particularly, the fractional excretion rate of urine Na, 0.5±0.2% in the normotensive group and 6.6±1.9% in the hypertensive group, showed a magnification factor of about 13 times (p<.005).

View Article: PubMed Central - PubMed

ABSTRACT

The fractional excretion of Na in hypertensive, reduced renal mass rats (saline-drinking) was higher than that of normotensive, reduced renal mass rats (water-drinking) (p&lt;.001). The plasma renin activities in the hypertensive group were markedly lower than those of the normotensive group (p&lt;.001).

The total ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than in those of the normal and the normotensive groups (p&lt;.001, p&lt;.02).

The Mg++-ATPase activities of rat erythrocyte membrane in the normotensive group tended to decrease significantly (p&lt;.001), but the differences between the normotensive and hypertensive group were not significant.

The Na+-K+ ATPase activities of rat erythrocyte membrane in the hypertensive group were lower than those of the normal and the normotensive group (p&lt;.001). However, the difference between the normal and the normotensive groups was not significant.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the total ATPase activities of erythrocyte membrane were not different from those of hypertensive rats.

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from normotensive rats, the Mg++ ATPase activities of erythrocyte membrane were lower than those of hypertensive rats (p&lt;.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p&lt;.01).

When erythrocyte membrane taken from normal rats was incubated with supernates of boiled plasma from hypertensive rats, the Na+-K+ ATPase activities of erythrocyte membrane were lower than those of normotensive rats (p&lt;.01).

Based on the above findings, it is suggested that the pathogenesis of low renin, reduced renal mass hypertension is primarily mediated by a natriuretic factor (or an ouabain-like factor, inhibitor of Na+-K+ ATPase) produced by extracellular fluid volume expansion.

Show MeSH