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High 24-hour urinary C-peptide excretion in non-insulin dependent diabetes mellitus.

Chung YH, Park KS, Lee KU, Kim SY, Lee HK, Min HK - Korean J. Intern. Med. (1986)

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ABSTRACT

The 24-hour urinary C-peptide excretion (UCPR) is a useful means of estimating total daily insulin secretion. To evaluate the daily insulin secretion rate in non-insulin dependent diabetes mellitus (NIDDM), we measured UCPR in 22 patients with NIDDM and 18 normal subjects. The mean (±SD) UCPR in the patients with NIDDM was 115.4±40.2 ug/day and that in normal subjects was 56.7±22.0 ug/day respectively with significantly higher values in the patients with NIDDM (P<0.0001). UCPR was positively correlated with body fat mass determined by measurement of skin fold thickness in both groups [r=0.51 in patients with NIDDM (n=22; p<0.02) and r=0.55 in normal subjects (n=18; p<0.02)], and was higher in NIDDM patients, even with the same degree of fat mass. There was no significant correlation between UCPR and body muscle mass both in the patients with NIDDM and normal subjects [r=0.16 in patients with NIDDM (n=22; p>0.1) and r=0.16 in normal subjects (n=18; p>0.1)]. This result suggested that the total daily insulin secretion rate in NIDDM be increased to compensate insulin resistance, especially that induced by adipose tissues.

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The relationship between UCPR and the body muscle mass.
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f3-kjim-1-2-172-7: The relationship between UCPR and the body muscle mass.

Mentions: There was good positive relationship between UCPR and body fat mass in both groups [r=0.51 in patients with NIDDM (n=22; p<0.02) and r=0.55 in normal subjects (n=18; p<0.02)]. UCPR in patients with NIDDM was higher than that in normal subjects, even with the same degree of fat mass (Fig. 2). In contrast no significant correlation was noted between UCPR and body muscle mass both in patients with NIDDM and normal subjects [r=0.16 in patients with NIDDM (n=22; p>0.1) and r=0.16 in normal subjects (n=18; p>0.1)] (Fig. 3).


High 24-hour urinary C-peptide excretion in non-insulin dependent diabetes mellitus.

Chung YH, Park KS, Lee KU, Kim SY, Lee HK, Min HK - Korean J. Intern. Med. (1986)

The relationship between UCPR and the body muscle mass.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4536715&req=5

f3-kjim-1-2-172-7: The relationship between UCPR and the body muscle mass.
Mentions: There was good positive relationship between UCPR and body fat mass in both groups [r=0.51 in patients with NIDDM (n=22; p<0.02) and r=0.55 in normal subjects (n=18; p<0.02)]. UCPR in patients with NIDDM was higher than that in normal subjects, even with the same degree of fat mass (Fig. 2). In contrast no significant correlation was noted between UCPR and body muscle mass both in patients with NIDDM and normal subjects [r=0.16 in patients with NIDDM (n=22; p>0.1) and r=0.16 in normal subjects (n=18; p>0.1)] (Fig. 3).

View Article: PubMed Central - PubMed

ABSTRACT

The 24-hour urinary C-peptide excretion (UCPR) is a useful means of estimating total daily insulin secretion. To evaluate the daily insulin secretion rate in non-insulin dependent diabetes mellitus (NIDDM), we measured UCPR in 22 patients with NIDDM and 18 normal subjects. The mean (&plusmn;SD) UCPR in the patients with NIDDM was 115.4&plusmn;40.2 ug/day and that in normal subjects was 56.7&plusmn;22.0 ug/day respectively with significantly higher values in the patients with NIDDM (P&lt;0.0001). UCPR was positively correlated with body fat mass determined by measurement of skin fold thickness in both groups [r=0.51 in patients with NIDDM (n=22; p&lt;0.02) and r=0.55 in normal subjects (n=18; p&lt;0.02)], and was higher in NIDDM patients, even with the same degree of fat mass. There was no significant correlation between UCPR and body muscle mass both in the patients with NIDDM and normal subjects [r=0.16 in patients with NIDDM (n=22; p&gt;0.1) and r=0.16 in normal subjects (n=18; p&gt;0.1)]. This result suggested that the total daily insulin secretion rate in NIDDM be increased to compensate insulin resistance, especially that induced by adipose tissues.

Show MeSH