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Analyses of RBC insulin receptor bindings in chronic liver disease.

Yoon KW, Choi SB, Choi MG, Lee HK, Kim CY, Min HK - Korean J. Intern. Med. (1986)

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ABSTRACT

125I-insulin binding to erythrocytes was measured to evaluate the role of insulin receptors in the mechanism of insulin resistance in partients with chronic liver disease (CLD). Patients with CLD were divided into two groups by the fasting plasma glucose level (FBS) and the glucose disappearance rate (k-glucose) during intravenous glucose tolerance tests: one with normal FBS and normal k-glucose (group I), and the other with higher FBS and lower k-glucose (group II). Insulin receptor bindings were reduced in group I patients compared with those of normal controls, but were not reduced in group II patients. Fasting insulin levels were significantly higher in group I patients than those in normal subjects, and down-regulation by hyperinsulinemia might be the cause of reduced insulin receptor bindings in these patients. However down-regulation of insulin receptors was not associated with glucose intolerance. So it is suggested that insulin resistance in CLD is not due to a primary defect of insulin receptors in peripheral tissues, and down-regulation of insulin receptors is an epiphenomenon of hyperinsulinemia.

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Mean Scatchard plots of data presented in Fig. 1.
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f2-kjim-1-2-140-2: Mean Scatchard plots of data presented in Fig. 1.

Mentions: The Scatchard plots of the mean values at each concentration of the bound insulin in three groups are shown in Fig. 2. Apparent receptor numbers of both high and low affinity receptors tended to be lower in the group I patients than those in normal controls, but the statistical differences of these indices between two groups (group I and normal controls) were not significant probably due to the small size of the samples (Table 2). Scatchard plot in group II patients were almost identical to that of normal subjects.


Analyses of RBC insulin receptor bindings in chronic liver disease.

Yoon KW, Choi SB, Choi MG, Lee HK, Kim CY, Min HK - Korean J. Intern. Med. (1986)

Mean Scatchard plots of data presented in Fig. 1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4536708&req=5

f2-kjim-1-2-140-2: Mean Scatchard plots of data presented in Fig. 1.
Mentions: The Scatchard plots of the mean values at each concentration of the bound insulin in three groups are shown in Fig. 2. Apparent receptor numbers of both high and low affinity receptors tended to be lower in the group I patients than those in normal controls, but the statistical differences of these indices between two groups (group I and normal controls) were not significant probably due to the small size of the samples (Table 2). Scatchard plot in group II patients were almost identical to that of normal subjects.

View Article: PubMed Central - PubMed

ABSTRACT

125I-insulin binding to erythrocytes was measured to evaluate the role of insulin receptors in the mechanism of insulin resistance in partients with chronic liver disease (CLD). Patients with CLD were divided into two groups by the fasting plasma glucose level (FBS) and the glucose disappearance rate (k-glucose) during intravenous glucose tolerance tests: one with normal FBS and normal k-glucose (group I), and the other with higher FBS and lower k-glucose (group II). Insulin receptor bindings were reduced in group I patients compared with those of normal controls, but were not reduced in group II patients. Fasting insulin levels were significantly higher in group I patients than those in normal subjects, and down-regulation by hyperinsulinemia might be the cause of reduced insulin receptor bindings in these patients. However down-regulation of insulin receptors was not associated with glucose intolerance. So it is suggested that insulin resistance in CLD is not due to a primary defect of insulin receptors in peripheral tissues, and down-regulation of insulin receptors is an epiphenomenon of hyperinsulinemia.

Show MeSH