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Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers.

Cojocneanu Petric R, Braicu C, Raduly L, Zanoaga O, Dragos N, Monroig P, Dumitrascu D, Berindan-Neagoe I - Onco Targets Ther (2015)

Bottom Line: Phytochemicals, in particular, have been shown to modulate oncogenic processes through their antioxidant and anti-inflammatory activities and their ability to mimic the chemical structure and activity of hormones.These compounds can act not only by influencing oncogenic proteins, but also by modulating noncoding RNAs such as microRNAs and long noncoding RNAs.Since ongoing studies continue to prove effective, herein we exalt the importance of improving dietary choices as a chemo-preventive strategy.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Babes-Bolyai University, Cluj-Napoca, Romania ; Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT
Over the years, nutrition and environmental factors have been demonstrated to influence human health, specifically cancer. Owing to the fact that cancer is a leading cause of death worldwide, efforts are being made to elucidate molecular mechanisms that trigger or delay carcinogenesis. Phytochemicals, in particular, have been shown to modulate oncogenic processes through their antioxidant and anti-inflammatory activities and their ability to mimic the chemical structure and activity of hormones. These compounds can act not only by influencing oncogenic proteins, but also by modulating noncoding RNAs such as microRNAs and long noncoding RNAs. Although we are only beginning to understand the complete effects of many natural compounds, such as phytochemicals, researchers are motivated to combine these agents with traditional, chemo-based, or hormone-based therapies to fight against cancer. Since ongoing studies continue to prove effective, herein we exalt the importance of improving dietary choices as a chemo-preventive strategy.

No MeSH data available.


Related in: MedlinePlus

The chemical structure of EGCG.Abbreviation: EGCG, epigallocatechin gallate.
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f3-ott-8-2053: The chemical structure of EGCG.Abbreviation: EGCG, epigallocatechin gallate.

Mentions: Epigallocatechin gallate (EGCG) (PubChem chemical structure identifier CID: 65064, Figure 3) is a polyphenol present in several natural sources, but mainly in green tea, which is among the most common beverages worldwide.35 EGCG has been long studied, and is known to have beneficial effects in various pathologies including neurodegenerative diseases, diabetes, strokes, and obesity. It can also have chemopreventive effects in several types of cancers.36 Its antioxidant effect appears to counteract the inflammatory processes that precede the development of malignancy, such as cellular transformation, sustained proliferation, and other characteristics that lead to tumorigenesis.


Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers.

Cojocneanu Petric R, Braicu C, Raduly L, Zanoaga O, Dragos N, Monroig P, Dumitrascu D, Berindan-Neagoe I - Onco Targets Ther (2015)

The chemical structure of EGCG.Abbreviation: EGCG, epigallocatechin gallate.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532173&req=5

f3-ott-8-2053: The chemical structure of EGCG.Abbreviation: EGCG, epigallocatechin gallate.
Mentions: Epigallocatechin gallate (EGCG) (PubChem chemical structure identifier CID: 65064, Figure 3) is a polyphenol present in several natural sources, but mainly in green tea, which is among the most common beverages worldwide.35 EGCG has been long studied, and is known to have beneficial effects in various pathologies including neurodegenerative diseases, diabetes, strokes, and obesity. It can also have chemopreventive effects in several types of cancers.36 Its antioxidant effect appears to counteract the inflammatory processes that precede the development of malignancy, such as cellular transformation, sustained proliferation, and other characteristics that lead to tumorigenesis.

Bottom Line: Phytochemicals, in particular, have been shown to modulate oncogenic processes through their antioxidant and anti-inflammatory activities and their ability to mimic the chemical structure and activity of hormones.These compounds can act not only by influencing oncogenic proteins, but also by modulating noncoding RNAs such as microRNAs and long noncoding RNAs.Since ongoing studies continue to prove effective, herein we exalt the importance of improving dietary choices as a chemo-preventive strategy.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Babes-Bolyai University, Cluj-Napoca, Romania ; Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT
Over the years, nutrition and environmental factors have been demonstrated to influence human health, specifically cancer. Owing to the fact that cancer is a leading cause of death worldwide, efforts are being made to elucidate molecular mechanisms that trigger or delay carcinogenesis. Phytochemicals, in particular, have been shown to modulate oncogenic processes through their antioxidant and anti-inflammatory activities and their ability to mimic the chemical structure and activity of hormones. These compounds can act not only by influencing oncogenic proteins, but also by modulating noncoding RNAs such as microRNAs and long noncoding RNAs. Although we are only beginning to understand the complete effects of many natural compounds, such as phytochemicals, researchers are motivated to combine these agents with traditional, chemo-based, or hormone-based therapies to fight against cancer. Since ongoing studies continue to prove effective, herein we exalt the importance of improving dietary choices as a chemo-preventive strategy.

No MeSH data available.


Related in: MedlinePlus