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Endobronchial metastasis of malignant melanoma, diagnosed by bronchoscopy--report of a case.

Kim HT, Kim YW, Kim SY, Bang YJ, Han SK, Kim NK, Kim KY, Han YC, Song HG, Lee HS - Korean J. Intern. Med. (1988)

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ABSTRACT

Endobronchial metastasis occurs in about 2% to 5% of patients dying of solid tumors of extrathoracic origin. These metastatic tumors can simulate bronchogenic carcinoma and presenting symptoms include cough, hemoptysis, dyspnea and wheezing. In most cases of endobronchial metastasis, the histologic finding of the bronchoscope biopsy suggests the correct diagnosis. There are only a few reports of endobronchial metastasis from malignant melanoma. We report a case of malignant melanoma with endobronchial metastasis presenting with hemoptysis simulating primary bronchogenic carcinoma.

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Fiberoptic bronchoscope photography showing a fungating dark grayish endobronchial mass at the orifice of the left lower lobe bronchus
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f3-kjim-3-1-77-12: Fiberoptic bronchoscope photography showing a fungating dark grayish endobronchial mass at the orifice of the left lower lobe bronchus

Mentions: Five weeks before admission she began to cough up blood-streaked sputum. In a recumbent position she suffered from mild dyspnea and wheezing respiration intermittently. Ten days before admission she coughed up frank blood. At the time of admission, the physical examination revealed wheezing and decreased breath sounds in the left lower lung field. Mucocutaneous lesions and palpable lymph nodes were not present. Chest roentgenogram showed left lower lobe collaps (Fig. 2). Laboratory data were normal except for lactic dehydrogenase (LDH) of 414 IU/L. Liver scan was normal. Four repeated sputum cytologic examinations were negative for malignant cells. Pulmonary function tests showed a moderate restrictive pattern. On bronchoscopy, a fungating, dark grayish, irregularly surfaced endobronchial mass at the orifice of the left lower lobe bronchus nearly completely occluding the lumen (Fig. 3) was found. Bronchoscopic biopsy revealed metastatic malignant melanoma (Fig. 4). Computed tomography of the chest showed left lower lobe collapse and aortic invasion (Fig. 5). So palliative chemotherapy with dimethyl triazeno imidazole carboxamide (DTIC) was given as a five day schedule and she was discharged.


Endobronchial metastasis of malignant melanoma, diagnosed by bronchoscopy--report of a case.

Kim HT, Kim YW, Kim SY, Bang YJ, Han SK, Kim NK, Kim KY, Han YC, Song HG, Lee HS - Korean J. Intern. Med. (1988)

Fiberoptic bronchoscope photography showing a fungating dark grayish endobronchial mass at the orifice of the left lower lobe bronchus
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532136&req=5

f3-kjim-3-1-77-12: Fiberoptic bronchoscope photography showing a fungating dark grayish endobronchial mass at the orifice of the left lower lobe bronchus
Mentions: Five weeks before admission she began to cough up blood-streaked sputum. In a recumbent position she suffered from mild dyspnea and wheezing respiration intermittently. Ten days before admission she coughed up frank blood. At the time of admission, the physical examination revealed wheezing and decreased breath sounds in the left lower lung field. Mucocutaneous lesions and palpable lymph nodes were not present. Chest roentgenogram showed left lower lobe collaps (Fig. 2). Laboratory data were normal except for lactic dehydrogenase (LDH) of 414 IU/L. Liver scan was normal. Four repeated sputum cytologic examinations were negative for malignant cells. Pulmonary function tests showed a moderate restrictive pattern. On bronchoscopy, a fungating, dark grayish, irregularly surfaced endobronchial mass at the orifice of the left lower lobe bronchus nearly completely occluding the lumen (Fig. 3) was found. Bronchoscopic biopsy revealed metastatic malignant melanoma (Fig. 4). Computed tomography of the chest showed left lower lobe collapse and aortic invasion (Fig. 5). So palliative chemotherapy with dimethyl triazeno imidazole carboxamide (DTIC) was given as a five day schedule and she was discharged.

View Article: PubMed Central - PubMed

ABSTRACT

Endobronchial metastasis occurs in about 2% to 5% of patients dying of solid tumors of extrathoracic origin. These metastatic tumors can simulate bronchogenic carcinoma and presenting symptoms include cough, hemoptysis, dyspnea and wheezing. In most cases of endobronchial metastasis, the histologic finding of the bronchoscope biopsy suggests the correct diagnosis. There are only a few reports of endobronchial metastasis from malignant melanoma. We report a case of malignant melanoma with endobronchial metastasis presenting with hemoptysis simulating primary bronchogenic carcinoma.

Show MeSH
Related in: MedlinePlus