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Influence of amineptine on changes of blood pressure evoked by norepinephrine and dopamine.

Lim DY, Lee KJ, Kim SH, Kim BH, Lee JJ, Lee EH, Chang KS, Hong SP - Korean J. Intern. Med. (1991)

Bottom Line: Furthermore, the pressor responses of NE and DA potentiated by pretreatment with debrisoquin, a sympathetic neuron blocker, were markedly diminished after pretreatment with the infusion of amineptine at the above same rate (1.5 mg/kg/30 min).These experimental results demonstrate that amineptine causes an inhibitory effect on the pressor responses evoked by NE and DA.It is thought that the amineptine effect may be due to the blockade of the peripheral adrenergic alpha-receptors in addition to the previously described uptake inhibition of dopamine.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Internal Medicine, Chosun University Medical College, Kwang Joo, Korea.

ABSTRACT
The influence of amineptine, an antidepressant currently employed having mainly selective dopaminergic neurochemical activity, on the pressor responses evoked by norepinephrine (NE) and dopamine (DA) was studied in anesthetized whole rats. Amineptine at doses of 0.5, 1.5, and 5.0 mg/kg/30 min infused into the femoral vein of the rat caused a dose-related inhibition of the pressor responses of NE and DA. The hypertensive responses of NE and DA augmented by pretreatment with reserpine, a catecholamine depletor, were also clearly depressed following the infusion of amineptine with a rate of 1.5 mg/kg/30 min. Furthermore, the pressor responses of NE and DA potentiated by pretreatment with debrisoquin, a sympathetic neuron blocker, were markedly diminished after pretreatment with the infusion of amineptine at the above same rate (1.5 mg/kg/30 min). These experimental results demonstrate that amineptine causes an inhibitory effect on the pressor responses evoked by NE and DA. It is thought that the amineptine effect may be due to the blockade of the peripheral adrenergic alpha-receptors in addition to the previously described uptake inhibition of dopamine.

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Influence of amineptine on pressor responses of dopamine potentiated by debrisoquine. Other legends and methods are the same as in Fig. 2. and 10. *: pä0.05, **: pä0.01
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f13-kjim-6-2-69-4: Influence of amineptine on pressor responses of dopamine potentiated by debrisoquine. Other legends and methods are the same as in Fig. 2. and 10. *: pä0.05, **: pä0.01

Mentions: In addition, dopamine-evoked pressor responses at doses of 10, 30, and 100 ug/kg, i.v. following debrisoquin (3.0 mg/kg) were distinctly augmented to 16.1±2.0, 24.9±2.4, and 32.7±3.8 mmHg, respectively, while after pretreatment with amineptine (3.0 mg/kg) the responses of DA at the above same dose were significantly diminished to 8.1±1.1 (n=6, pä0.01), 14.9±2.2 (n=6, pä0.01), and 22.5±3.4 (n=6, pä0.05) mmHg, respectively, as shown in Fig. 13.


Influence of amineptine on changes of blood pressure evoked by norepinephrine and dopamine.

Lim DY, Lee KJ, Kim SH, Kim BH, Lee JJ, Lee EH, Chang KS, Hong SP - Korean J. Intern. Med. (1991)

Influence of amineptine on pressor responses of dopamine potentiated by debrisoquine. Other legends and methods are the same as in Fig. 2. and 10. *: pä0.05, **: pä0.01
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532118&req=5

f13-kjim-6-2-69-4: Influence of amineptine on pressor responses of dopamine potentiated by debrisoquine. Other legends and methods are the same as in Fig. 2. and 10. *: pä0.05, **: pä0.01
Mentions: In addition, dopamine-evoked pressor responses at doses of 10, 30, and 100 ug/kg, i.v. following debrisoquin (3.0 mg/kg) were distinctly augmented to 16.1±2.0, 24.9±2.4, and 32.7±3.8 mmHg, respectively, while after pretreatment with amineptine (3.0 mg/kg) the responses of DA at the above same dose were significantly diminished to 8.1±1.1 (n=6, pä0.01), 14.9±2.2 (n=6, pä0.01), and 22.5±3.4 (n=6, pä0.05) mmHg, respectively, as shown in Fig. 13.

Bottom Line: Furthermore, the pressor responses of NE and DA potentiated by pretreatment with debrisoquin, a sympathetic neuron blocker, were markedly diminished after pretreatment with the infusion of amineptine at the above same rate (1.5 mg/kg/30 min).These experimental results demonstrate that amineptine causes an inhibitory effect on the pressor responses evoked by NE and DA.It is thought that the amineptine effect may be due to the blockade of the peripheral adrenergic alpha-receptors in addition to the previously described uptake inhibition of dopamine.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Internal Medicine, Chosun University Medical College, Kwang Joo, Korea.

ABSTRACT
The influence of amineptine, an antidepressant currently employed having mainly selective dopaminergic neurochemical activity, on the pressor responses evoked by norepinephrine (NE) and dopamine (DA) was studied in anesthetized whole rats. Amineptine at doses of 0.5, 1.5, and 5.0 mg/kg/30 min infused into the femoral vein of the rat caused a dose-related inhibition of the pressor responses of NE and DA. The hypertensive responses of NE and DA augmented by pretreatment with reserpine, a catecholamine depletor, were also clearly depressed following the infusion of amineptine with a rate of 1.5 mg/kg/30 min. Furthermore, the pressor responses of NE and DA potentiated by pretreatment with debrisoquin, a sympathetic neuron blocker, were markedly diminished after pretreatment with the infusion of amineptine at the above same rate (1.5 mg/kg/30 min). These experimental results demonstrate that amineptine causes an inhibitory effect on the pressor responses evoked by NE and DA. It is thought that the amineptine effect may be due to the blockade of the peripheral adrenergic alpha-receptors in addition to the previously described uptake inhibition of dopamine.

Show MeSH