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Histologic study of chronic active hepatitis C; comparison with chronic active hepatitis B.

Hahm KB, Chon CY, Kim WH, Han KH, Chung JB, Lee SI, Moon YM, Kang JK, Park IS, Choi HJ - Korean J. Intern. Med. (1992)

Bottom Line: Severe sinusoidal lymphocytic reactions were also more prominent in the CAH-C group (11 of 19 cases) than in the CAH-B group (6 of 19 cases).However, periportal necroinflammation, portal fibrosis, focal hepatic necrosis, regeneration and polyploid nuclear changes were more prominent in the CAH-B group than in the CAH-C group.In conclusion, follicular portal inflammation and severe sinusoidal lymphocytic reactions were common histologic findings in serologically proven CAH-C when compared to CAH-B.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Reports on the histologic findings of chronic active hepatitis C (CAH-C) have been rare, and the characteristic histologic findings of CAH-C have been not yet determined. To compare the differences in the histologic findings between CAH-C and chronic active hepatitis B (CAH-B) group, we analyzed the histologic findings of 19 patients with CAH-C, who had positive tests for HCV-antibody by EIA, and 19 patients with CAH-B who had negative tests for HCV-antibody but positive tests for HBsAg by RIA. Histologic features were analyzed between the CAH-C and CAH-B groups using a scoring system which is modified from Knodell's histologic activity index-looking at portal inflammation, periportal necroinflammation, portal fibrosis, focal necrosis, regeneration, polyploid nuclear change, sinusoidal lymphocytic reaction and fatty change. Portal inflammatory cell infiltrations with prominent lymphocytes and follicular arrangement were more frequent in the CAH-C group (10 of 19 cases) than in the CAH-B group (5 of 19 cases). Severe sinusoidal lymphocytic reactions were also more prominent in the CAH-C group (11 of 19 cases) than in the CAH-B group (6 of 19 cases). However, periportal necroinflammation, portal fibrosis, focal hepatic necrosis, regeneration and polyploid nuclear changes were more prominent in the CAH-B group than in the CAH-C group. In conclusion, follicular portal inflammation and severe sinusoidal lymphocytic reactions were common histologic findings in serologically proven CAH-C when compared to CAH-B.

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Histopathologic appearance of sinusoidal lymphocytic reaction, mild to moderate (HAI 1, left) and severe sinusoidal lymphocytic reaction (HAI 2, right).
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f6-kjim-7-2-102-5: Histopathologic appearance of sinusoidal lymphocytic reaction, mild to moderate (HAI 1, left) and severe sinusoidal lymphocytic reaction (HAI 2, right).

Mentions: More severe sinusoidal lymphocytic reactions in relation to the degree of the hepatic necrosis were noted more frequently in the CAH-C group (57.9%) than in the CAH-B group (31.6%). Thus, severe sinusoidal lymphocytic reaction can predict the morphologic characteristics of CAH-C (Table 8, Fig. 6).


Histologic study of chronic active hepatitis C; comparison with chronic active hepatitis B.

Hahm KB, Chon CY, Kim WH, Han KH, Chung JB, Lee SI, Moon YM, Kang JK, Park IS, Choi HJ - Korean J. Intern. Med. (1992)

Histopathologic appearance of sinusoidal lymphocytic reaction, mild to moderate (HAI 1, left) and severe sinusoidal lymphocytic reaction (HAI 2, right).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532114&req=5

f6-kjim-7-2-102-5: Histopathologic appearance of sinusoidal lymphocytic reaction, mild to moderate (HAI 1, left) and severe sinusoidal lymphocytic reaction (HAI 2, right).
Mentions: More severe sinusoidal lymphocytic reactions in relation to the degree of the hepatic necrosis were noted more frequently in the CAH-C group (57.9%) than in the CAH-B group (31.6%). Thus, severe sinusoidal lymphocytic reaction can predict the morphologic characteristics of CAH-C (Table 8, Fig. 6).

Bottom Line: Severe sinusoidal lymphocytic reactions were also more prominent in the CAH-C group (11 of 19 cases) than in the CAH-B group (6 of 19 cases).However, periportal necroinflammation, portal fibrosis, focal hepatic necrosis, regeneration and polyploid nuclear changes were more prominent in the CAH-B group than in the CAH-C group.In conclusion, follicular portal inflammation and severe sinusoidal lymphocytic reactions were common histologic findings in serologically proven CAH-C when compared to CAH-B.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Reports on the histologic findings of chronic active hepatitis C (CAH-C) have been rare, and the characteristic histologic findings of CAH-C have been not yet determined. To compare the differences in the histologic findings between CAH-C and chronic active hepatitis B (CAH-B) group, we analyzed the histologic findings of 19 patients with CAH-C, who had positive tests for HCV-antibody by EIA, and 19 patients with CAH-B who had negative tests for HCV-antibody but positive tests for HBsAg by RIA. Histologic features were analyzed between the CAH-C and CAH-B groups using a scoring system which is modified from Knodell's histologic activity index-looking at portal inflammation, periportal necroinflammation, portal fibrosis, focal necrosis, regeneration, polyploid nuclear change, sinusoidal lymphocytic reaction and fatty change. Portal inflammatory cell infiltrations with prominent lymphocytes and follicular arrangement were more frequent in the CAH-C group (10 of 19 cases) than in the CAH-B group (5 of 19 cases). Severe sinusoidal lymphocytic reactions were also more prominent in the CAH-C group (11 of 19 cases) than in the CAH-B group (6 of 19 cases). However, periportal necroinflammation, portal fibrosis, focal hepatic necrosis, regeneration and polyploid nuclear changes were more prominent in the CAH-B group than in the CAH-C group. In conclusion, follicular portal inflammation and severe sinusoidal lymphocytic reactions were common histologic findings in serologically proven CAH-C when compared to CAH-B.

Show MeSH
Related in: MedlinePlus