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Heterogeneous changes of serum potassium levels in NIDDM patients on oral glucose load.

Bae HY, Kim HJ - Korean J. Intern. Med. (1992)

Bottom Line: Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels.On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels.These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chosun University, Kwangju, Korea.

ABSTRACT
Ten noninsulin dependent diabetic patients (NIDDM) without baseline hyperkalemia and with normal aldosterone levels when given 100 g of glucose orally revealed heterogeneous responses in serum potassium changes. Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels. On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels. These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load. This finding suggests that osmotic mechanisms with various degree of well known abnormal insulin secretion and resistance to insulin action in target tissues in NIDDM patients may account for these heterogeneous responses in serum potassium changes after glucose load, and normal aldosterone levels may not be sufficient to prevent glucose induced increases in serum potassium in NIDDM patients.

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Correlation between mean values of changes of serum glucose and those of osmolar changes at 30, 60, 90 and 120 minutes after glucose load in all three groups.
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f3-kjim-7-1-39-7: Correlation between mean values of changes of serum glucose and those of osmolar changes at 30, 60, 90 and 120 minutes after glucose load in all three groups.

Mentions: Changes in mean values of blood glucose after glucose administration were significantly higher in group 2 than group 1 and group 3 at 60, 90 and 120 minutes (p<0.01 at 60 min., p<0.005 at 90 and 120 min.) (Fig. 2). There was a direct correlation between mean values of increments in serum glucose and those in serum osmolar changes (r=0.85, p<0.001) on 2 hours time course as well as between mean values of increments in serum potassium and those in serum osmolar changes on 2 hours time course (r=0.68, p<0.01) (Fig. 3, 4).


Heterogeneous changes of serum potassium levels in NIDDM patients on oral glucose load.

Bae HY, Kim HJ - Korean J. Intern. Med. (1992)

Correlation between mean values of changes of serum glucose and those of osmolar changes at 30, 60, 90 and 120 minutes after glucose load in all three groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532097&req=5

f3-kjim-7-1-39-7: Correlation between mean values of changes of serum glucose and those of osmolar changes at 30, 60, 90 and 120 minutes after glucose load in all three groups.
Mentions: Changes in mean values of blood glucose after glucose administration were significantly higher in group 2 than group 1 and group 3 at 60, 90 and 120 minutes (p<0.01 at 60 min., p<0.005 at 90 and 120 min.) (Fig. 2). There was a direct correlation between mean values of increments in serum glucose and those in serum osmolar changes (r=0.85, p<0.001) on 2 hours time course as well as between mean values of increments in serum potassium and those in serum osmolar changes on 2 hours time course (r=0.68, p<0.01) (Fig. 3, 4).

Bottom Line: Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels.On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels.These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chosun University, Kwangju, Korea.

ABSTRACT
Ten noninsulin dependent diabetic patients (NIDDM) without baseline hyperkalemia and with normal aldosterone levels when given 100 g of glucose orally revealed heterogeneous responses in serum potassium changes. Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels. On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels. These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load. This finding suggests that osmotic mechanisms with various degree of well known abnormal insulin secretion and resistance to insulin action in target tissues in NIDDM patients may account for these heterogeneous responses in serum potassium changes after glucose load, and normal aldosterone levels may not be sufficient to prevent glucose induced increases in serum potassium in NIDDM patients.

Show MeSH
Related in: MedlinePlus