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Heterogeneous changes of serum potassium levels in NIDDM patients on oral glucose load.

Bae HY, Kim HJ - Korean J. Intern. Med. (1992)

Bottom Line: Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels.On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels.These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chosun University, Kwangju, Korea.

ABSTRACT
Ten noninsulin dependent diabetic patients (NIDDM) without baseline hyperkalemia and with normal aldosterone levels when given 100 g of glucose orally revealed heterogeneous responses in serum potassium changes. Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels. On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels. These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load. This finding suggests that osmotic mechanisms with various degree of well known abnormal insulin secretion and resistance to insulin action in target tissues in NIDDM patients may account for these heterogeneous responses in serum potassium changes after glucose load, and normal aldosterone levels may not be sufficient to prevent glucose induced increases in serum potassium in NIDDM patients.

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Changes in mean values (±SE) of serum potassium on time course to controls (group 1) and to diabetics with (group 2) and without (group 3) paradoxical increases of it after glucose load. *p<0.01 compared to group 1 and 3
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f1-kjim-7-1-39-7: Changes in mean values (±SE) of serum potassium on time course to controls (group 1) and to diabetics with (group 2) and without (group 3) paradoxical increases of it after glucose load. *p<0.01 compared to group 1 and 3

Mentions: Ten noninsulin dependent diabetic patients, after the administration of 100 g of oral glucose, were divided into six patients with gradual paradoxical increases of mean values of changes from baseline serum potassium levels (group 2) unlike nondiabetic control subjects (group 1) and four patients with similar decreases of it (group 3) to four nondiabetic control subjects as shown in Table 1 and Fig. 1. Sex distribution of the study subjects revealed predominance in males, except equal numbers in group 3. Ages and known duration of NIDDM were similar between group 2 and 3, but ages of controls (group 1) were much younger.


Heterogeneous changes of serum potassium levels in NIDDM patients on oral glucose load.

Bae HY, Kim HJ - Korean J. Intern. Med. (1992)

Changes in mean values (±SE) of serum potassium on time course to controls (group 1) and to diabetics with (group 2) and without (group 3) paradoxical increases of it after glucose load. *p<0.01 compared to group 1 and 3
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532097&req=5

f1-kjim-7-1-39-7: Changes in mean values (±SE) of serum potassium on time course to controls (group 1) and to diabetics with (group 2) and without (group 3) paradoxical increases of it after glucose load. *p<0.01 compared to group 1 and 3
Mentions: Ten noninsulin dependent diabetic patients, after the administration of 100 g of oral glucose, were divided into six patients with gradual paradoxical increases of mean values of changes from baseline serum potassium levels (group 2) unlike nondiabetic control subjects (group 1) and four patients with similar decreases of it (group 3) to four nondiabetic control subjects as shown in Table 1 and Fig. 1. Sex distribution of the study subjects revealed predominance in males, except equal numbers in group 3. Ages and known duration of NIDDM were similar between group 2 and 3, but ages of controls (group 1) were much younger.

Bottom Line: Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels.On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels.These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Chosun University, Kwangju, Korea.

ABSTRACT
Ten noninsulin dependent diabetic patients (NIDDM) without baseline hyperkalemia and with normal aldosterone levels when given 100 g of glucose orally revealed heterogeneous responses in serum potassium changes. Six diabetics had paradoxical increases in serum potassium levels averaged 0.44 mEq/L (range, 0.1 to 1.1 mEq/L) and were accompanied by increases in plasma aldosterone levels. On the contrary, four other noninsulin dependent diabetics and four nondiabetic control subjects had gradual decreases in serum potassium levels with simultaneous decreases in plasma aldosterone levels. These rises and falls in serum potassium concentrations coincided with changes in serum osmolality related mostly to the degree of increases in serum glucose following oral glucose administration. pH of venous blood didn't show any relevant and significant changes with changes of serum potassium levels following oral glucose load. This finding suggests that osmotic mechanisms with various degree of well known abnormal insulin secretion and resistance to insulin action in target tissues in NIDDM patients may account for these heterogeneous responses in serum potassium changes after glucose load, and normal aldosterone levels may not be sufficient to prevent glucose induced increases in serum potassium in NIDDM patients.

Show MeSH
Related in: MedlinePlus