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The effect of eradication of Helicobacter pylori upon the duodenal ulcer recurrence--a 24 month follow-up study.

Kim NY, Oh HS, Jung MH, Wee SH, Choi JH, Lee KH - Korean J. Intern. Med. (1994)

Bottom Line: To evaluate the effect of eradication of Helicobacter pylori(H.pylori) in the patients with duodenal ulcer(Du) upon the DU recurrence.The recurrence rate was 3.2% both in 1 year and 2 years later in the former group-one consisting of 31 patients with H. pylori eradicated, while the recurrence rate was 57.1% in 1 year and 78.6% in 2 years later, in the latter group-the other of 42 patients with H. pylori not eradicated.The eradication of H. pylori in patients with DU reduces the recurrence of DU.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kangnam General Hospital, Public Corporation, Seoul, Korea.

ABSTRACT

Objectives: To evaluate the effect of eradication of Helicobacter pylori(H.pylori) in the patients with duodenal ulcer(Du) upon the DU recurrence.

Methods: This study was performed for 190 patients with DU. Four different methods-microscopy of Gram stained mucosal smear, specific culture, biopsy urease test, histology of H &E staining-were taken for identifying colonization of H. pylori before treatment, and for finding the eradication of H. pylori 4 weeks after completion of therapy in each treatment group (cometidine, omeprazole, colloidal bismuth subcitrate(CBS), CBS and metronidazole double therapy, CBS, metronidazole and amoxicillin triple therapy). To detect DU recurrence, the gastroscopy was performed at 6, 12, 18, and 24 months after therapy.

Results: The eradication rate of the cimetidine group the omeprazole group, and the CBS group were 0%, 7.7%, 0%, respectively, and that of the double therapy group and the triple therapy group were 44.4% and 89.3%, respectively. Seventy three patients who were followed up for 2 years were categorized into two groups according to the eradication of H. pylori. The recurrence rate was 3.2% both in 1 year and 2 years later in the former group-one consisting of 31 patients with H. pylori eradicated, while the recurrence rate was 57.1% in 1 year and 78.6% in 2 years later, in the latter group-the other of 42 patients with H. pylori not eradicated.

Conclusion: The eradication of H. pylori in patients with DU reduces the recurrence of DU.

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Recurrence rate of duodenal ulcer in each treatment group.OMPZ;omeprazole, CBS;colloidal bismuth subcitrate, MT;metronidazole, AMX;amoxicillin
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f2-kjim-9-2-72-4: Recurrence rate of duodenal ulcer in each treatment group.OMPZ;omeprazole, CBS;colloidal bismuth subcitrate, MT;metronidazole, AMX;amoxicillin

Mentions: Of the 82 patients analyzed for eradication of H. pylori, one patient in the cimetidine group, 3 patients in the CBS group, 2 patients in the double therapy group and one patient in the triple therapy group were excluded in the analysis of DU recurrence rate due to treatment failure. One patient of the omeprazole group and one patient of the triple therapy group in both of whom H. pylori was eradicated were excluded due to loss of follow-up. So 73 patients remained for the analysis of DU recurrence rate(Table 1). The DU recurrence rate of the 11 patients in the cimetidine group was 36.4%(4 patients) in 6 months, 63.6%(7 patients) in 1 year, 81.8%(9 patients) in 18 months and 90.9%(10 patients) in 2 years later, respectively. For the 12 patients in the omeprazole group, that was 33.3%(4 patients) in 6 months, 75.0%(9 patients) in 1 year, and 83.3%(10 patients) both in 18 months and 2 years later. All of the recurrence cases in the omeprazole group were patients with the H. pylori not eradicated. For the 8 patients in CBS group, that was 37.5%(3 patients) both in 6 months and 1 year, 50.0%(4 patients) in 18 months, and 75.0%(6 patients) in 2 years later. There was no statistical significance between any two groups of the cimetidine group, the omeprazole group and the CBS group. For the 16 patients in the double therapyrapy group, that was 18.8%(3 patients) in 6 months later, 25.0%(4 patients) in 1 year later, and 37.5%(6 patients) both in 18 months and 2 years later. The rate of 1 year of the double therapy group was significantly lower than that of the omeprazole group, and the rates of 18 months and 2 years than those of the cimetidine group and the omeprazole group(Fig. 2). All of the recurrence cases in the double therapy group were patients with H. pylori not eradicated. For the 26 patients in the triple therapy group, that was 3.8%(one patient) in 6 months, 7.7%(2 patients) in 1 year, and 11.5%(3 patients) both in 18 months and 2 years later. These rates of triple therapy group were significantly lower than those of the cimetidine group, the omeprazole group and the CBS group, and the rates of 18 months and 2 years than those of the double therapy group, respectively(Fig. 2). One of the 3 recurring patients in the triple therapy group was H. pylori eradicated case, and H. pylori test, taken when DU recurred 9 months later in this patient, was positive.


The effect of eradication of Helicobacter pylori upon the duodenal ulcer recurrence--a 24 month follow-up study.

Kim NY, Oh HS, Jung MH, Wee SH, Choi JH, Lee KH - Korean J. Intern. Med. (1994)

Recurrence rate of duodenal ulcer in each treatment group.OMPZ;omeprazole, CBS;colloidal bismuth subcitrate, MT;metronidazole, AMX;amoxicillin
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532069&req=5

f2-kjim-9-2-72-4: Recurrence rate of duodenal ulcer in each treatment group.OMPZ;omeprazole, CBS;colloidal bismuth subcitrate, MT;metronidazole, AMX;amoxicillin
Mentions: Of the 82 patients analyzed for eradication of H. pylori, one patient in the cimetidine group, 3 patients in the CBS group, 2 patients in the double therapy group and one patient in the triple therapy group were excluded in the analysis of DU recurrence rate due to treatment failure. One patient of the omeprazole group and one patient of the triple therapy group in both of whom H. pylori was eradicated were excluded due to loss of follow-up. So 73 patients remained for the analysis of DU recurrence rate(Table 1). The DU recurrence rate of the 11 patients in the cimetidine group was 36.4%(4 patients) in 6 months, 63.6%(7 patients) in 1 year, 81.8%(9 patients) in 18 months and 90.9%(10 patients) in 2 years later, respectively. For the 12 patients in the omeprazole group, that was 33.3%(4 patients) in 6 months, 75.0%(9 patients) in 1 year, and 83.3%(10 patients) both in 18 months and 2 years later. All of the recurrence cases in the omeprazole group were patients with the H. pylori not eradicated. For the 8 patients in CBS group, that was 37.5%(3 patients) both in 6 months and 1 year, 50.0%(4 patients) in 18 months, and 75.0%(6 patients) in 2 years later. There was no statistical significance between any two groups of the cimetidine group, the omeprazole group and the CBS group. For the 16 patients in the double therapyrapy group, that was 18.8%(3 patients) in 6 months later, 25.0%(4 patients) in 1 year later, and 37.5%(6 patients) both in 18 months and 2 years later. The rate of 1 year of the double therapy group was significantly lower than that of the omeprazole group, and the rates of 18 months and 2 years than those of the cimetidine group and the omeprazole group(Fig. 2). All of the recurrence cases in the double therapy group were patients with H. pylori not eradicated. For the 26 patients in the triple therapy group, that was 3.8%(one patient) in 6 months, 7.7%(2 patients) in 1 year, and 11.5%(3 patients) both in 18 months and 2 years later. These rates of triple therapy group were significantly lower than those of the cimetidine group, the omeprazole group and the CBS group, and the rates of 18 months and 2 years than those of the double therapy group, respectively(Fig. 2). One of the 3 recurring patients in the triple therapy group was H. pylori eradicated case, and H. pylori test, taken when DU recurred 9 months later in this patient, was positive.

Bottom Line: To evaluate the effect of eradication of Helicobacter pylori(H.pylori) in the patients with duodenal ulcer(Du) upon the DU recurrence.The recurrence rate was 3.2% both in 1 year and 2 years later in the former group-one consisting of 31 patients with H. pylori eradicated, while the recurrence rate was 57.1% in 1 year and 78.6% in 2 years later, in the latter group-the other of 42 patients with H. pylori not eradicated.The eradication of H. pylori in patients with DU reduces the recurrence of DU.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kangnam General Hospital, Public Corporation, Seoul, Korea.

ABSTRACT

Objectives: To evaluate the effect of eradication of Helicobacter pylori(H.pylori) in the patients with duodenal ulcer(Du) upon the DU recurrence.

Methods: This study was performed for 190 patients with DU. Four different methods-microscopy of Gram stained mucosal smear, specific culture, biopsy urease test, histology of H &E staining-were taken for identifying colonization of H. pylori before treatment, and for finding the eradication of H. pylori 4 weeks after completion of therapy in each treatment group (cometidine, omeprazole, colloidal bismuth subcitrate(CBS), CBS and metronidazole double therapy, CBS, metronidazole and amoxicillin triple therapy). To detect DU recurrence, the gastroscopy was performed at 6, 12, 18, and 24 months after therapy.

Results: The eradication rate of the cimetidine group the omeprazole group, and the CBS group were 0%, 7.7%, 0%, respectively, and that of the double therapy group and the triple therapy group were 44.4% and 89.3%, respectively. Seventy three patients who were followed up for 2 years were categorized into two groups according to the eradication of H. pylori. The recurrence rate was 3.2% both in 1 year and 2 years later in the former group-one consisting of 31 patients with H. pylori eradicated, while the recurrence rate was 57.1% in 1 year and 78.6% in 2 years later, in the latter group-the other of 42 patients with H. pylori not eradicated.

Conclusion: The eradication of H. pylori in patients with DU reduces the recurrence of DU.

Show MeSH
Related in: MedlinePlus