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A case of amiodarone-associated pulmonary toxicity.

Kwon KH, Jeong SW, Uh S, Kim YH, Jin SY, Park JS, Kang CH, Park CS - Korean J. Intern. Med. (1995)

Bottom Line: Amiodarone is an iodinated benzofuran derivative that represents a new and extremely effective therapy for certain life-threatening refractory cardiac arrgythmia.There are numerous side effects associated with amiodarone therapy, including corneal microdeposits.Skin reactions and others.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Anatomical Pathology, College of Medicine, Soon Chun Hy ang University, Seoul, Korea.

ABSTRACT
Amiodarone is an iodinated benzofuran derivative that represents a new and extremely effective therapy for certain life-threatening refractory cardiac arrgythmia. There are numerous side effects associated with amiodarone therapy, including corneal microdeposits. Skin reactions and others. Pulmonary toxicity, however, represents the most serious adverse reaction limiting the clinical effecacy of this antidysrhythmic drug. Recently, we experienced a case of amiodarone-induced pulmonary toxicity confirmed by open lung biopsy with light-and electron-microscopy. So, we report a case of amiodarone-induced pulmonary toxicity with a literature review.

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Related in: MedlinePlus

The initial chest radiolograph shows multiple air space consolidations bilaterally.
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f1-kjim-10-2-155-13: The initial chest radiolograph shows multiple air space consolidations bilaterally.

Mentions: The urine was normal. The hematocrit was 33%; the white-cell count was 36300/mm3, with 83% neutrophils and 1% eosinophils. The ESR was 60mm/hour. The blood chemical findings were normal. Values were normal for urea nitrogen, creatinine, glucose, sGOT, sGPT, alkaline phosphatase, bilirubin and protein(albumin and globulin), the serologic tests for rheumatoid factor, anti-nuclear antibody, LE cell and anti-double strand DNA Ab were negative. The arterial blood gas analysis showed PH; 7.40, PaCo2; 39mmHg, PaO2; 43mmHg, HCO3; 24mmol/L, The electocardiogram showed normal sinus rhythm with complete right bundle branch block pattern. The chest P-A showed confluent increased density in right upper lobe, right middle lobe and both lower lobes with blunting of left costophrenic angle, and also Derlie’s B line in both lower lung fields (Fig. 1).


A case of amiodarone-associated pulmonary toxicity.

Kwon KH, Jeong SW, Uh S, Kim YH, Jin SY, Park JS, Kang CH, Park CS - Korean J. Intern. Med. (1995)

The initial chest radiolograph shows multiple air space consolidations bilaterally.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532041&req=5

f1-kjim-10-2-155-13: The initial chest radiolograph shows multiple air space consolidations bilaterally.
Mentions: The urine was normal. The hematocrit was 33%; the white-cell count was 36300/mm3, with 83% neutrophils and 1% eosinophils. The ESR was 60mm/hour. The blood chemical findings were normal. Values were normal for urea nitrogen, creatinine, glucose, sGOT, sGPT, alkaline phosphatase, bilirubin and protein(albumin and globulin), the serologic tests for rheumatoid factor, anti-nuclear antibody, LE cell and anti-double strand DNA Ab were negative. The arterial blood gas analysis showed PH; 7.40, PaCo2; 39mmHg, PaO2; 43mmHg, HCO3; 24mmol/L, The electocardiogram showed normal sinus rhythm with complete right bundle branch block pattern. The chest P-A showed confluent increased density in right upper lobe, right middle lobe and both lower lobes with blunting of left costophrenic angle, and also Derlie’s B line in both lower lung fields (Fig. 1).

Bottom Line: Amiodarone is an iodinated benzofuran derivative that represents a new and extremely effective therapy for certain life-threatening refractory cardiac arrgythmia.There are numerous side effects associated with amiodarone therapy, including corneal microdeposits.Skin reactions and others.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Anatomical Pathology, College of Medicine, Soon Chun Hy ang University, Seoul, Korea.

ABSTRACT
Amiodarone is an iodinated benzofuran derivative that represents a new and extremely effective therapy for certain life-threatening refractory cardiac arrgythmia. There are numerous side effects associated with amiodarone therapy, including corneal microdeposits. Skin reactions and others. Pulmonary toxicity, however, represents the most serious adverse reaction limiting the clinical effecacy of this antidysrhythmic drug. Recently, we experienced a case of amiodarone-induced pulmonary toxicity confirmed by open lung biopsy with light-and electron-microscopy. So, we report a case of amiodarone-induced pulmonary toxicity with a literature review.

Show MeSH
Related in: MedlinePlus