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Predictive factors for beneficial response to interferon-alfa therapy in chronic hepatitis C.

Yoon SK, Kim SS, Park YM, Shim KS, Lee CD, Sun HS, Park DH, Kim BS, Ryu WS, Cho JM - Korean J. Intern. Med. (1995)

Bottom Line: Sustained responders were 8 (36.4%), nonsustained responders were 2 (9.1%) and nonresponders were 12 (54.5%) of 22 patients who had received complete therapy.The initial HCV RNA level (logarithmic transformed copy numbers per ml of serum) in sustained responders (5.75 +/- 0.39) was significantly lower than that of nonsustained responders (6.80 +/- 0.71) and nonresponders (6.70 +/- 0.52) (p < 0.05).In multivariate multiple logistic regression analysis, the serum HCV RNA level before therapy was only the independent predictor of a sustained response to interferon-alfa therapy (p = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.

ABSTRACT

Objectives: Interferon is the only established treatment for chronic hepatitis C but the host-dependent or virus-related factors affecting the response rate to interferon therapy are not yet clear. The purpose of this study was to investigate the factors predictive of response to interferon-alfa therapy in chronic hepatitis C.

Methods: Twenty-five consecutive patients with chronic hepatitis C were randomized to three regimens of interferon-alfa: group A (n = 7, 3 MU every day for 3 months), group B (n = 8, 3 MU every other day for 3 months) and group C (n = 10, 3 MU every other day for 6 months). We quantified serum HC RNA levels by competitive reverse transcription-polymerase chain reaction (RT-PCR) and performed HCV genotyping using type-specific primers deduced form the NS5 region of the HCV genome. We also attempted to identify which demographic, biochemical and histologic factors in addition to virus-related factors would significantly predict beneficial response to interferon by multivariate analysis.

Results: Sustained responders were 8 (36.4%), nonsustained responders were 2 (9.1%) and nonresponders were 12 (54.5%) of 22 patients who had received complete therapy. The initial HCV RNA level (logarithmic transformed copy numbers per ml of serum) in sustained responders (5.75 +/- 0.39) was significantly lower than that of nonsustained responders (6.80 +/- 0.71) and nonresponders (6.70 +/- 0.52) (p < 0.05). In multivariate multiple logistic regression analysis, the serum HCV RNA level before therapy was only the independent predictor of a sustained response to interferon-alfa therapy (p = 0.001).

Conclusions: Serum HCV RNA level before therapy was the most useful predictor of a sustained response to interferon-alfa therapy for chronic hepatitis C.

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Related in: MedlinePlus

Detection of each HCV genotype by reverse transcription-nested polymerase chain reaction using the genotype specific primers deduced from NS5 region of HCV genome.The upper portion [A] shows HCV-J (1b) type while the lower portion[B] shows HCV-K2a (2a) type. The letter “L” indicates molecular weight size marker (123 bp).
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f1-kjim-10-2-94-3: Detection of each HCV genotype by reverse transcription-nested polymerase chain reaction using the genotype specific primers deduced from NS5 region of HCV genome.The upper portion [A] shows HCV-J (1b) type while the lower portion[B] shows HCV-K2a (2a) type. The letter “L” indicates molecular weight size marker (123 bp).

Mentions: The results of HCV grnotyping shown in Table 3 and Fig. 1. 14 of 22 patients (63.6%) were genotype 1b, 7 of 22 patients (31.8%) were HCV 2a type and 1 patient had an undetermined type. In response to IFN-α according to HCV genotype, 5 (35.7%), 2 (14.3%) and 7 (50.0%) of 14 patients with HCV 1b type showed SR, NSR and NR, respectively. Of 7 patients with HCV 2a type, 3 (42.9%) and 4(57.1%) had SR and NR, respectively. No significant correlation between response to IFN-α and genotype was seen.


Predictive factors for beneficial response to interferon-alfa therapy in chronic hepatitis C.

Yoon SK, Kim SS, Park YM, Shim KS, Lee CD, Sun HS, Park DH, Kim BS, Ryu WS, Cho JM - Korean J. Intern. Med. (1995)

Detection of each HCV genotype by reverse transcription-nested polymerase chain reaction using the genotype specific primers deduced from NS5 region of HCV genome.The upper portion [A] shows HCV-J (1b) type while the lower portion[B] shows HCV-K2a (2a) type. The letter “L” indicates molecular weight size marker (123 bp).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532038&req=5

f1-kjim-10-2-94-3: Detection of each HCV genotype by reverse transcription-nested polymerase chain reaction using the genotype specific primers deduced from NS5 region of HCV genome.The upper portion [A] shows HCV-J (1b) type while the lower portion[B] shows HCV-K2a (2a) type. The letter “L” indicates molecular weight size marker (123 bp).
Mentions: The results of HCV grnotyping shown in Table 3 and Fig. 1. 14 of 22 patients (63.6%) were genotype 1b, 7 of 22 patients (31.8%) were HCV 2a type and 1 patient had an undetermined type. In response to IFN-α according to HCV genotype, 5 (35.7%), 2 (14.3%) and 7 (50.0%) of 14 patients with HCV 1b type showed SR, NSR and NR, respectively. Of 7 patients with HCV 2a type, 3 (42.9%) and 4(57.1%) had SR and NR, respectively. No significant correlation between response to IFN-α and genotype was seen.

Bottom Line: Sustained responders were 8 (36.4%), nonsustained responders were 2 (9.1%) and nonresponders were 12 (54.5%) of 22 patients who had received complete therapy.The initial HCV RNA level (logarithmic transformed copy numbers per ml of serum) in sustained responders (5.75 +/- 0.39) was significantly lower than that of nonsustained responders (6.80 +/- 0.71) and nonresponders (6.70 +/- 0.52) (p < 0.05).In multivariate multiple logistic regression analysis, the serum HCV RNA level before therapy was only the independent predictor of a sustained response to interferon-alfa therapy (p = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.

ABSTRACT

Objectives: Interferon is the only established treatment for chronic hepatitis C but the host-dependent or virus-related factors affecting the response rate to interferon therapy are not yet clear. The purpose of this study was to investigate the factors predictive of response to interferon-alfa therapy in chronic hepatitis C.

Methods: Twenty-five consecutive patients with chronic hepatitis C were randomized to three regimens of interferon-alfa: group A (n = 7, 3 MU every day for 3 months), group B (n = 8, 3 MU every other day for 3 months) and group C (n = 10, 3 MU every other day for 6 months). We quantified serum HC RNA levels by competitive reverse transcription-polymerase chain reaction (RT-PCR) and performed HCV genotyping using type-specific primers deduced form the NS5 region of the HCV genome. We also attempted to identify which demographic, biochemical and histologic factors in addition to virus-related factors would significantly predict beneficial response to interferon by multivariate analysis.

Results: Sustained responders were 8 (36.4%), nonsustained responders were 2 (9.1%) and nonresponders were 12 (54.5%) of 22 patients who had received complete therapy. The initial HCV RNA level (logarithmic transformed copy numbers per ml of serum) in sustained responders (5.75 +/- 0.39) was significantly lower than that of nonsustained responders (6.80 +/- 0.71) and nonresponders (6.70 +/- 0.52) (p < 0.05). In multivariate multiple logistic regression analysis, the serum HCV RNA level before therapy was only the independent predictor of a sustained response to interferon-alfa therapy (p = 0.001).

Conclusions: Serum HCV RNA level before therapy was the most useful predictor of a sustained response to interferon-alfa therapy for chronic hepatitis C.

Show MeSH
Related in: MedlinePlus