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A case of adult-onset Bartter's syndrome.

Park JW, Chung YJ, Yeum CH, Lee JJ, Yoo KS, Kim SW, Kim NH, Choi KC, Kang YJ - Korean J. Intern. Med. (1995)

Bottom Line: Bartter's Syndrome is characterized by renal potassium wasting with hypokalemia, metabolic alkalosis, increased renin-angiotensin-aldosterone system, normal blood pressure, resistance to the pressor effects of angiotensin II and juxtaglomerular cell hyperplasia.Most of the cases have been noted in the pediatric age group and adult-onset cases are very rare.We report a case of adult-onset Bartter's syndrome.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam University Medical School, Kwangju, Korea.

ABSTRACT
Bartter's Syndrome is characterized by renal potassium wasting with hypokalemia, metabolic alkalosis, increased renin-angiotensin-aldosterone system, normal blood pressure, resistance to the pressor effects of angiotensin II and juxtaglomerular cell hyperplasia. Most of the cases have been noted in the pediatric age group and adult-onset cases are very rare. We report a case of adult-onset Bartter's syndrome.

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Related in: MedlinePlus

Increased number of cells lie in the afferent arteriole at the hilum of the glomerulus and multiple vacuoles in the proximal tubules. Light microscopy, Homatoxylin and eosin stain, origisnal magnification × 200.
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f1-kjim-10-1-60-10: Increased number of cells lie in the afferent arteriole at the hilum of the glomerulus and multiple vacuoles in the proximal tubules. Light microscopy, Homatoxylin and eosin stain, origisnal magnification × 200.

Mentions: The renal biopsy was performed without difficulty. The biopsy specimen contained up to 8 glomeruli per section. Some glomeruli revealed focal and segmental glomerulosclerotic changes. Juxtaglomerular hyperplasia of varying degrees and multiple vacuolization of proximal tubule due to chronic hypokalemia were noted (Fig. 1, 2). The tubules, interstitium and blood vessels were entirely normal with no scarring or atrophy. The constellation of hypokalemia, relative hypotension, increased renin activity, increased aldosterone level and juxtaglomerular hyperplasia substantiated the diagnosis of Bartter’s syndrome.


A case of adult-onset Bartter's syndrome.

Park JW, Chung YJ, Yeum CH, Lee JJ, Yoo KS, Kim SW, Kim NH, Choi KC, Kang YJ - Korean J. Intern. Med. (1995)

Increased number of cells lie in the afferent arteriole at the hilum of the glomerulus and multiple vacuoles in the proximal tubules. Light microscopy, Homatoxylin and eosin stain, origisnal magnification × 200.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532024&req=5

f1-kjim-10-1-60-10: Increased number of cells lie in the afferent arteriole at the hilum of the glomerulus and multiple vacuoles in the proximal tubules. Light microscopy, Homatoxylin and eosin stain, origisnal magnification × 200.
Mentions: The renal biopsy was performed without difficulty. The biopsy specimen contained up to 8 glomeruli per section. Some glomeruli revealed focal and segmental glomerulosclerotic changes. Juxtaglomerular hyperplasia of varying degrees and multiple vacuolization of proximal tubule due to chronic hypokalemia were noted (Fig. 1, 2). The tubules, interstitium and blood vessels were entirely normal with no scarring or atrophy. The constellation of hypokalemia, relative hypotension, increased renin activity, increased aldosterone level and juxtaglomerular hyperplasia substantiated the diagnosis of Bartter’s syndrome.

Bottom Line: Bartter's Syndrome is characterized by renal potassium wasting with hypokalemia, metabolic alkalosis, increased renin-angiotensin-aldosterone system, normal blood pressure, resistance to the pressor effects of angiotensin II and juxtaglomerular cell hyperplasia.Most of the cases have been noted in the pediatric age group and adult-onset cases are very rare.We report a case of adult-onset Bartter's syndrome.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam University Medical School, Kwangju, Korea.

ABSTRACT
Bartter's Syndrome is characterized by renal potassium wasting with hypokalemia, metabolic alkalosis, increased renin-angiotensin-aldosterone system, normal blood pressure, resistance to the pressor effects of angiotensin II and juxtaglomerular cell hyperplasia. Most of the cases have been noted in the pediatric age group and adult-onset cases are very rare. We report a case of adult-onset Bartter's syndrome.

Show MeSH
Related in: MedlinePlus