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Clinical features of ulcerative colitis in Korea.

Park SM, Han DS, Yang SK, Hong WS, Min YI - Korean J. Intern. Med. (1996)

Bottom Line: The severity of disease was determined according to the clinical criteria, resulting in 22 (33.3%) mild, 21 (31.8%) moderate and 23 (34.8%) severe diseases.The median disease-free interval from the time of remission was 10 months (range, 2-60).After remission, the subsequent relapse rate increased in severe disease, while no difference was observed between the disease extents.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Ulsan, Seoul, Korea.

ABSTRACT

Objectives: This study was conducted to investigate the clinical features of ulcerative colitis in Korea and to evaluate the clinical course after medical therapy.

Methods: Symptoms, signs and results of the treatment were retrospectively analyzed in 66 patients (male 32, female 34) diagnosed to have ulcerative colitis at the Asan Medical Center.

Results: The median age of the beginning of symptoms was 36 years (range, 14-72). Diarrhea and rectal bleeding were observed in 95.1 and 91.4%, respectively, at the time of diagnosis, while extra-colonic manifestations were observed in 24.1%. In 41 patients (62.1%), colitis developed in the rectum and sigmoid colon, while left colitis and extensive colitis developed in 11 (16.7%) and 14 patients (21.2%), respectively. The severity of disease was determined according to the clinical criteria, resulting in 22 (33.3%) mild, 21 (31.8%) moderate and 23 (34.8%) severe diseases. The seventy was also classified as 1, 2 and 3 by sigmoidocolonoscopic findings: 1;17 patients(25.8%), 2;27(40.9%) and 22(33.3%). Among 23 patients with severe disease, 5 patients (7.6%) received total colectomy due to toxic megacolon, intractability to medical therapy, ileocolic fistula and intestinal stenosis. The severity determined by colonoscopic findings was well correlated with that determined clinically and was closely related to the severity of symptoms, levels of albumin, hemoglobin and the count of leukocyte. The median duration of symptoms before treatment was 4 weeks (range, 11-300). All patients were treated with sulfasalazine and prednisolone. All patients with medical therapy, except 2 patients (96.7%), obtained clinical remission. The median days required for remission was 14 (range, 3-70). Relapse rates at 6 months, 1 year and 2 years after the initiation of treatment were 19.7, 34.1 and 49.3%, respectively. The median disease-free interval from the time of remission was 10 months (range, 2-60). After remission, the subsequent relapse rate increased in severe disease, while no difference was observed between the disease extents.

Conclusions: The general characteristics of clinical manifestations and clinical course, after the medical treatment of ulcerative colitis in Korean patients, are not considerably different from those in Western countries.

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Relapse rate in 59 patients with clinically remission in ulcerative colitis according to the disease extent : proctitis (*), distal colitis (●), left colitis (■), extensive colitis (•) and total (○).
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f5-kjim-11-1-9-2: Relapse rate in 59 patients with clinically remission in ulcerative colitis according to the disease extent : proctitis (*), distal colitis (●), left colitis (■), extensive colitis (•) and total (○).

Mentions: Among 61 patients treated with medical therapy alone, 59 patients (96.7%) achieved remission. The median period required for the remission was 14 days (range, 3–70). In 2 cases, symptoms were improved by the medical therapy but did not reach to the remission criteria. The median disease free interval after the remission was 10 months (range, 2–60). The relapse increased with time and was 19.7, 34.1 and 49.3 in 6 months, 1 year and 2 years after remission. The relapse rates increased with the increase in the disease severity (p<0.05), (Fig. 4). On the other hand, no significant difference in the relapse rates was observed between the disease extents (p>0.05) (Fig. 5).


Clinical features of ulcerative colitis in Korea.

Park SM, Han DS, Yang SK, Hong WS, Min YI - Korean J. Intern. Med. (1996)

Relapse rate in 59 patients with clinically remission in ulcerative colitis according to the disease extent : proctitis (*), distal colitis (●), left colitis (■), extensive colitis (•) and total (○).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532005&req=5

f5-kjim-11-1-9-2: Relapse rate in 59 patients with clinically remission in ulcerative colitis according to the disease extent : proctitis (*), distal colitis (●), left colitis (■), extensive colitis (•) and total (○).
Mentions: Among 61 patients treated with medical therapy alone, 59 patients (96.7%) achieved remission. The median period required for the remission was 14 days (range, 3–70). In 2 cases, symptoms were improved by the medical therapy but did not reach to the remission criteria. The median disease free interval after the remission was 10 months (range, 2–60). The relapse increased with time and was 19.7, 34.1 and 49.3 in 6 months, 1 year and 2 years after remission. The relapse rates increased with the increase in the disease severity (p<0.05), (Fig. 4). On the other hand, no significant difference in the relapse rates was observed between the disease extents (p>0.05) (Fig. 5).

Bottom Line: The severity of disease was determined according to the clinical criteria, resulting in 22 (33.3%) mild, 21 (31.8%) moderate and 23 (34.8%) severe diseases.The median disease-free interval from the time of remission was 10 months (range, 2-60).After remission, the subsequent relapse rate increased in severe disease, while no difference was observed between the disease extents.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Ulsan, Seoul, Korea.

ABSTRACT

Objectives: This study was conducted to investigate the clinical features of ulcerative colitis in Korea and to evaluate the clinical course after medical therapy.

Methods: Symptoms, signs and results of the treatment were retrospectively analyzed in 66 patients (male 32, female 34) diagnosed to have ulcerative colitis at the Asan Medical Center.

Results: The median age of the beginning of symptoms was 36 years (range, 14-72). Diarrhea and rectal bleeding were observed in 95.1 and 91.4%, respectively, at the time of diagnosis, while extra-colonic manifestations were observed in 24.1%. In 41 patients (62.1%), colitis developed in the rectum and sigmoid colon, while left colitis and extensive colitis developed in 11 (16.7%) and 14 patients (21.2%), respectively. The severity of disease was determined according to the clinical criteria, resulting in 22 (33.3%) mild, 21 (31.8%) moderate and 23 (34.8%) severe diseases. The seventy was also classified as 1, 2 and 3 by sigmoidocolonoscopic findings: 1;17 patients(25.8%), 2;27(40.9%) and 22(33.3%). Among 23 patients with severe disease, 5 patients (7.6%) received total colectomy due to toxic megacolon, intractability to medical therapy, ileocolic fistula and intestinal stenosis. The severity determined by colonoscopic findings was well correlated with that determined clinically and was closely related to the severity of symptoms, levels of albumin, hemoglobin and the count of leukocyte. The median duration of symptoms before treatment was 4 weeks (range, 11-300). All patients were treated with sulfasalazine and prednisolone. All patients with medical therapy, except 2 patients (96.7%), obtained clinical remission. The median days required for remission was 14 (range, 3-70). Relapse rates at 6 months, 1 year and 2 years after the initiation of treatment were 19.7, 34.1 and 49.3%, respectively. The median disease-free interval from the time of remission was 10 months (range, 2-60). After remission, the subsequent relapse rate increased in severe disease, while no difference was observed between the disease extents.

Conclusions: The general characteristics of clinical manifestations and clinical course, after the medical treatment of ulcerative colitis in Korean patients, are not considerably different from those in Western countries.

Show MeSH
Related in: MedlinePlus