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Acute lung injury after phosgene inhalation.

Lim SC, Yang JY, Jang AS, Park YU, Kim YC, Choi IS, Park KO - Korean J. Intern. Med. (1996)

Bottom Line: Phosgene (COCl2) is a colorless oxidant gas which is heavier than air and the lethal exposure dose (LC50) in humans is 500 ppm/min.In Korea, there has been no report about lung injury from phosgene inhalation.We present a clinical experience with six patients accidentally exposed to phosgene.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University, Kwangju, Korea.

ABSTRACT
Phosgene (COCl2) is a colorless oxidant gas which is heavier than air and the lethal exposure dose (LC50) in humans is 500 ppm/min. This gas was originally manufactured as an agent for chemical warfare during World War I and there had been a great deal of studies on phosgene poisoning during the early years of industrial use. It is still widely used in the synthesis of chemicals and plastics. In the modern era, however, phosgene poisoning is relatively uncommon except in accidental exposures. In Korea, there has been no report about lung injury from phosgene inhalation. We present a clinical experience with six patients accidentally exposed to phosgene.

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Related in: MedlinePlus

Chest roentgenogram of case 1 on the day of admission, showing severe degree of pulmonary edema.
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f1-kjim-11-1-87-11: Chest roentgenogram of case 1 on the day of admission, showing severe degree of pulmonary edema.

Mentions: Admitting vital signs were blood pressure 100/60 mmHg. pulse 110/min, respiration 20/min, temperature 36.4°C. Examination of the chest revealed bilateral inspiratory and expiratory crackles. The chest X-ray showed diffuse increased haziness on both lung field (Fig. 1). The WBC were 12.7 × 103/μl, the LDH 409 unit, initial arterial blood gases determinations on room air were, PaO2, 68.9 mmHg, PaCO2, 34.7 mmHg, pH, 7.392.


Acute lung injury after phosgene inhalation.

Lim SC, Yang JY, Jang AS, Park YU, Kim YC, Choi IS, Park KO - Korean J. Intern. Med. (1996)

Chest roentgenogram of case 1 on the day of admission, showing severe degree of pulmonary edema.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532002&req=5

f1-kjim-11-1-87-11: Chest roentgenogram of case 1 on the day of admission, showing severe degree of pulmonary edema.
Mentions: Admitting vital signs were blood pressure 100/60 mmHg. pulse 110/min, respiration 20/min, temperature 36.4°C. Examination of the chest revealed bilateral inspiratory and expiratory crackles. The chest X-ray showed diffuse increased haziness on both lung field (Fig. 1). The WBC were 12.7 × 103/μl, the LDH 409 unit, initial arterial blood gases determinations on room air were, PaO2, 68.9 mmHg, PaCO2, 34.7 mmHg, pH, 7.392.

Bottom Line: Phosgene (COCl2) is a colorless oxidant gas which is heavier than air and the lethal exposure dose (LC50) in humans is 500 ppm/min.In Korea, there has been no report about lung injury from phosgene inhalation.We present a clinical experience with six patients accidentally exposed to phosgene.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University, Kwangju, Korea.

ABSTRACT
Phosgene (COCl2) is a colorless oxidant gas which is heavier than air and the lethal exposure dose (LC50) in humans is 500 ppm/min. This gas was originally manufactured as an agent for chemical warfare during World War I and there had been a great deal of studies on phosgene poisoning during the early years of industrial use. It is still widely used in the synthesis of chemicals and plastics. In the modern era, however, phosgene poisoning is relatively uncommon except in accidental exposures. In Korea, there has been no report about lung injury from phosgene inhalation. We present a clinical experience with six patients accidentally exposed to phosgene.

Show MeSH
Related in: MedlinePlus