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Prognostic factors of patients with thymoma.

Lee WS, Heo DS, Bang YJ, Lee KS, Ahn JS, Jung CW, Han SK, Sung SW, Kim JH, Shim YS, Park CI, Kim NK - Korean J. Intern. Med. (1996)

Bottom Line: Two complete responses and seven partial responses (overall response rate of 53%) were observed with a median response duration of fourteen months.Combination chemotherapy with CAP was effective.However, the presence of myasthenia gravis or the extent of resection in stage III patients was not associated with the survival time.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Objectives: To analyze the prognostic factors influencing the survival of patients with thymoma, clinical characteristics, treatment modalities and survival of patients were evaluated. The efficacy of chemotherapy was also determined.

Methods: Retrospective study was done on one hundred patients whose diagnosis was confirmed pathologically at Seoul National University Hospital from 1981 to 1994. The staging was carried out according to the Masaoka system. Survival rate was calculated by the Kaplan-Meier method and prognostic factors were analyzed by a multivariate analysis (Weibull model).

Results: The stage of 100 patients was as follows: Stage I-50, II-6, III-27, IV A-10, IV B-7. The overall survival rates at 5 and 10 years after diagnosis were 73.1% and 58.7%, respectively. The 5-year survival differences, according to various prognostic factors, were as follows: 1) Stage: I-92.8%, II-100%, III-71.6%, IVA-25.9% and IVB-32.9% (p = 0.0029). 2) Age: < 60 years-79.5% and > or = 60 years-41.5% (p = 0.0489). 3) Extent of resection: Total patients: complete resection-87.6% and incomplete resection-50.5% (p > 0.05) Stage III: complete resection-66.7% and incomplete resection-75.5% (p > 0.05) 4) Myasthenia gravis: present-71.6% and absent-74.9% (p > 0.05) Seventeen patients were treated with a combination chemotherapy of Cyclophosphamide, Adriamycin and cisplatin(CAP). Two complete responses and seven partial responses (overall response rate of 53%) were observed with a median response duration of fourteen months. Combination chemotherapy with CAP was effective.

Conclusions: Stage and age were the independent prognostic factors in patients with thymoma. However, the presence of myasthenia gravis or the extent of resection in stage III patients was not associated with the survival time.

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Overall survival according to age.
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f3-kjim-11-1-40-5: Overall survival according to age.

Mentions: We divided the patients into two groups : less than 60 and greater than 60. Then we calculated the survival rate and found a survival difference between the two groups (p<0.05) (Fig. 3).


Prognostic factors of patients with thymoma.

Lee WS, Heo DS, Bang YJ, Lee KS, Ahn JS, Jung CW, Han SK, Sung SW, Kim JH, Shim YS, Park CI, Kim NK - Korean J. Intern. Med. (1996)

Overall survival according to age.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4532000&req=5

f3-kjim-11-1-40-5: Overall survival according to age.
Mentions: We divided the patients into two groups : less than 60 and greater than 60. Then we calculated the survival rate and found a survival difference between the two groups (p<0.05) (Fig. 3).

Bottom Line: Two complete responses and seven partial responses (overall response rate of 53%) were observed with a median response duration of fourteen months.Combination chemotherapy with CAP was effective.However, the presence of myasthenia gravis or the extent of resection in stage III patients was not associated with the survival time.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Objectives: To analyze the prognostic factors influencing the survival of patients with thymoma, clinical characteristics, treatment modalities and survival of patients were evaluated. The efficacy of chemotherapy was also determined.

Methods: Retrospective study was done on one hundred patients whose diagnosis was confirmed pathologically at Seoul National University Hospital from 1981 to 1994. The staging was carried out according to the Masaoka system. Survival rate was calculated by the Kaplan-Meier method and prognostic factors were analyzed by a multivariate analysis (Weibull model).

Results: The stage of 100 patients was as follows: Stage I-50, II-6, III-27, IV A-10, IV B-7. The overall survival rates at 5 and 10 years after diagnosis were 73.1% and 58.7%, respectively. The 5-year survival differences, according to various prognostic factors, were as follows: 1) Stage: I-92.8%, II-100%, III-71.6%, IVA-25.9% and IVB-32.9% (p = 0.0029). 2) Age: < 60 years-79.5% and > or = 60 years-41.5% (p = 0.0489). 3) Extent of resection: Total patients: complete resection-87.6% and incomplete resection-50.5% (p > 0.05) Stage III: complete resection-66.7% and incomplete resection-75.5% (p > 0.05) 4) Myasthenia gravis: present-71.6% and absent-74.9% (p > 0.05) Seventeen patients were treated with a combination chemotherapy of Cyclophosphamide, Adriamycin and cisplatin(CAP). Two complete responses and seven partial responses (overall response rate of 53%) were observed with a median response duration of fourteen months. Combination chemotherapy with CAP was effective.

Conclusions: Stage and age were the independent prognostic factors in patients with thymoma. However, the presence of myasthenia gravis or the extent of resection in stage III patients was not associated with the survival time.

Show MeSH
Related in: MedlinePlus