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The role of mucosal biopsy in the diagnosis of chronic diarrhea: value of multiple biopsies when colonoscopic finding is normal or nonspecific.

Lee JH, Rhee PL, Kim JJ, Koh KC, Paik SW, Han JH, Ree HJ, Rhee JC - Korean J. Intern. Med. (1997)

Bottom Line: One hundred and eighteen patients suffering from nonbloody diarrhea with average frequency of more than two times a day for more than 4 weeks were included.Ninety two cases (78.8%) showed nonspecific inflammation only.Clinically important histological lesions can exist in significant percentage in spite of normal or nonspecific colonoscopic findings, which can justify routine mucosal biopsy in the evaluation of chronic diarrhea patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Sung Kyun Kwan University College of Medicine, Samsung medical Center, Seoul, Korea.

ABSTRACT

Objectives: There are controversies about taking routine mucosal biopsy when the gross colonoscopic finding is normal. This study was conducted to determine the frequency of clinically important histological abnormalities, prospectively, in chronic diarrhea patients with grossly normal or nonspecific colonoscopic findings.

Methods: One hundred and eighteen patients suffering from nonbloody diarrhea with average frequency of more than two times a day for more than 4 weeks were included. Multiple biopsies (cecum, ascending colon, mid-transverse colon, descending colon, sigmoid colon and rectum) were taken during colonoscopic examinations and each biopsy specimen was reviewed by one pathologist after H&E and Masson-trichrome staining.

Results: Clinically significant abnormalities (2 collagenous colitis, 1 lymphocytic colitis, 1 eosinophilic enterocolitis, 1 ulcerative colitis and 4 melanosis coli) were observed in 9 patients (7.6%). Sixteen cases (13.6%) of borderline histological abnormalities were observed (8 cases of possible collagenous colitis and 8 cases showing some features of lymphocytic colitis). Ninety two cases (78.8%) showed nonspecific inflammation only.

Conclusion: Clinically important histological lesions can exist in significant percentage in spite of normal or nonspecific colonoscopic findings, which can justify routine mucosal biopsy in the evaluation of chronic diarrhea patients. The clinical significance of borderline histological abnormalities needs to be determined by careful follow-up studies.

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Summary of histological findings observed in chronic diarrhea patients showing normal or nonspecific colonoscopic findings.
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f3-kjim-12-2-182-9: Summary of histological findings observed in chronic diarrhea patients showing normal or nonspecific colonoscopic findings.

Mentions: In summary, among 118 patients included, 7.6% of patients showed clinically significant histological abnormalities (collagenous colitis, lymphocytic colitis, eosinophilic enterocolitis, ulcerative colitis and melanosis coli), and 13.5% of patients showed borderline histological abnormalities (Fig. 3).


The role of mucosal biopsy in the diagnosis of chronic diarrhea: value of multiple biopsies when colonoscopic finding is normal or nonspecific.

Lee JH, Rhee PL, Kim JJ, Koh KC, Paik SW, Han JH, Ree HJ, Rhee JC - Korean J. Intern. Med. (1997)

Summary of histological findings observed in chronic diarrhea patients showing normal or nonspecific colonoscopic findings.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4531994&req=5

f3-kjim-12-2-182-9: Summary of histological findings observed in chronic diarrhea patients showing normal or nonspecific colonoscopic findings.
Mentions: In summary, among 118 patients included, 7.6% of patients showed clinically significant histological abnormalities (collagenous colitis, lymphocytic colitis, eosinophilic enterocolitis, ulcerative colitis and melanosis coli), and 13.5% of patients showed borderline histological abnormalities (Fig. 3).

Bottom Line: One hundred and eighteen patients suffering from nonbloody diarrhea with average frequency of more than two times a day for more than 4 weeks were included.Ninety two cases (78.8%) showed nonspecific inflammation only.Clinically important histological lesions can exist in significant percentage in spite of normal or nonspecific colonoscopic findings, which can justify routine mucosal biopsy in the evaluation of chronic diarrhea patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Sung Kyun Kwan University College of Medicine, Samsung medical Center, Seoul, Korea.

ABSTRACT

Objectives: There are controversies about taking routine mucosal biopsy when the gross colonoscopic finding is normal. This study was conducted to determine the frequency of clinically important histological abnormalities, prospectively, in chronic diarrhea patients with grossly normal or nonspecific colonoscopic findings.

Methods: One hundred and eighteen patients suffering from nonbloody diarrhea with average frequency of more than two times a day for more than 4 weeks were included. Multiple biopsies (cecum, ascending colon, mid-transverse colon, descending colon, sigmoid colon and rectum) were taken during colonoscopic examinations and each biopsy specimen was reviewed by one pathologist after H&E and Masson-trichrome staining.

Results: Clinically significant abnormalities (2 collagenous colitis, 1 lymphocytic colitis, 1 eosinophilic enterocolitis, 1 ulcerative colitis and 4 melanosis coli) were observed in 9 patients (7.6%). Sixteen cases (13.6%) of borderline histological abnormalities were observed (8 cases of possible collagenous colitis and 8 cases showing some features of lymphocytic colitis). Ninety two cases (78.8%) showed nonspecific inflammation only.

Conclusion: Clinically important histological lesions can exist in significant percentage in spite of normal or nonspecific colonoscopic findings, which can justify routine mucosal biopsy in the evaluation of chronic diarrhea patients. The clinical significance of borderline histological abnormalities needs to be determined by careful follow-up studies.

Show MeSH
Related in: MedlinePlus