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A case of lymphomatoid papulosis occurred simultaneously with Ki-1-positive anaplastic large cell lymphoma.

Lee NS, Cha SW, Hong SJ, Shin WY, Lee GT, Jeon JW, Won JH, Baick SH, Hong DS, Park HS - Korean J. Intern. Med. (1997)

Bottom Line: Lymphomatoid papulosis (LyP) is a chronic self-healing skin eruption that is clinically benign but histologically mimics a malignant lymphoma.We experienced a 60-year-old male patient with lymphomatoid papulosis occurred simultaneously with relapsed Ki-1-positive anaplastic large cell lymphoma who was treated with salvage chemotherapy but, unfortunately, failed to be rescued.We report it with a review of the literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Soonchunhyang University, College of Medicine, Seoul, Korea.

ABSTRACT
Lymphomatoid papulosis (LyP) is a chronic self-healing skin eruption that is clinically benign but histologically mimics a malignant lymphoma. However, lymphomatoid papulosis with anaplastic large cell lymphoma responds poorly to medical treatments, including chemotherapies. We experienced a 60-year-old male patient with lymphomatoid papulosis occurred simultaneously with relapsed Ki-1-positive anaplastic large cell lymphoma who was treated with salvage chemotherapy but, unfortunately, failed to be rescued. We report it with a review of the literature.

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Histologic findings of lymph node show large pleomorphic tumor cells with irregular nuclear profiles and abundant dense cytoplasm (H & E stain, ×400).
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f1-kjim-12-1-84-16: Histologic findings of lymph node show large pleomorphic tumor cells with irregular nuclear profiles and abundant dense cytoplasm (H & E stain, ×400).

Mentions: There was a history of pulmonary tuberculosis up to 10 years ago, and he had taken drugs for a year. A year prior to admission, he had had a history of enlargement of both cervical lymph nodes and postprandial epigastric pain, which was diagnosed to be early gastric cancer, Ki-1-positive anaplastic lymphoma, stage IIIB involving right submandibular lymph nodes, left cervical lymph nodes and hepatoduodenal lymph nodes (Fig. 1) without bone marrow involvement. At that time, he was treated with 6 cycle combination chemotherapy of ProMACE-CytaBOM regimen for Ki-1-positive anaplastic lymphoma during 6 months. Subtotal gastrectomy and gastroduodenostomy were performed for early gastric cancer after 2 cycles of chemotherapy. After 6 cycle combination chemotherapy, he was on complete remission of the disease.


A case of lymphomatoid papulosis occurred simultaneously with Ki-1-positive anaplastic large cell lymphoma.

Lee NS, Cha SW, Hong SJ, Shin WY, Lee GT, Jeon JW, Won JH, Baick SH, Hong DS, Park HS - Korean J. Intern. Med. (1997)

Histologic findings of lymph node show large pleomorphic tumor cells with irregular nuclear profiles and abundant dense cytoplasm (H & E stain, ×400).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4531975&req=5

f1-kjim-12-1-84-16: Histologic findings of lymph node show large pleomorphic tumor cells with irregular nuclear profiles and abundant dense cytoplasm (H & E stain, ×400).
Mentions: There was a history of pulmonary tuberculosis up to 10 years ago, and he had taken drugs for a year. A year prior to admission, he had had a history of enlargement of both cervical lymph nodes and postprandial epigastric pain, which was diagnosed to be early gastric cancer, Ki-1-positive anaplastic lymphoma, stage IIIB involving right submandibular lymph nodes, left cervical lymph nodes and hepatoduodenal lymph nodes (Fig. 1) without bone marrow involvement. At that time, he was treated with 6 cycle combination chemotherapy of ProMACE-CytaBOM regimen for Ki-1-positive anaplastic lymphoma during 6 months. Subtotal gastrectomy and gastroduodenostomy were performed for early gastric cancer after 2 cycles of chemotherapy. After 6 cycle combination chemotherapy, he was on complete remission of the disease.

Bottom Line: Lymphomatoid papulosis (LyP) is a chronic self-healing skin eruption that is clinically benign but histologically mimics a malignant lymphoma.We experienced a 60-year-old male patient with lymphomatoid papulosis occurred simultaneously with relapsed Ki-1-positive anaplastic large cell lymphoma who was treated with salvage chemotherapy but, unfortunately, failed to be rescued.We report it with a review of the literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Soonchunhyang University, College of Medicine, Seoul, Korea.

ABSTRACT
Lymphomatoid papulosis (LyP) is a chronic self-healing skin eruption that is clinically benign but histologically mimics a malignant lymphoma. However, lymphomatoid papulosis with anaplastic large cell lymphoma responds poorly to medical treatments, including chemotherapies. We experienced a 60-year-old male patient with lymphomatoid papulosis occurred simultaneously with relapsed Ki-1-positive anaplastic large cell lymphoma who was treated with salvage chemotherapy but, unfortunately, failed to be rescued. We report it with a review of the literature.

Show MeSH
Related in: MedlinePlus