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IgE production from the nasal polyp tissue: comparison between atopic and non-atopic subjects.

Kim HY, Nahm DH, Suh KS, Park HS - Korean J. Intern. Med. (1998)

Bottom Line: Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10).A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04).The possibility of an isolated local production of IgE antibody was suggested.

View Article: PubMed Central - PubMed

Affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objectives and methods: To confirm the local production of IgE antibody from the nasal polyp tissue, and to evaluate the difference between atopics and non-atopics, nasal polyp tissues were taken from both 10 atopic and 10 non-atopic subjects. The tissue total IgE (tlgE) level was measured by enzyme-linked immunosorbent assay (ELISA) and serum tlgE level by radio-immunoassay. The tissue albumin level was measured by nephelometry, and serum albumin level by Bromocresol green method.

Results: The polyp tissue tlgE/albumin as well as serum tlgE/albumin ratio were significantly higher in atopics than in non-atopics (p < 0.05), with no difference in the albumin level between the two groups (p > 0.05). Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10). A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04). The ratio of polyp tlgE/albumin to serum tlgE/albumin was greater than 1 in all of the non-atopic subjects and 7 of 10 atopic subjects.

Conclusion: These findings support the hypothesis that IgE antibody could be locally produced from the nasal polyp tissue of non-atopic subjects as well as atopic subjects. The possibility of an isolated local production of IgE antibody was suggested.

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Comparison of total IgE/albumin ratio from serum and nasal polyp tissue between atopic and non-atopic subjects.
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f2-kjim-13-2-83-2: Comparison of total IgE/albumin ratio from serum and nasal polyp tissue between atopic and non-atopic subjects.

Mentions: When the serum total IgE level was presented as the ratio of total IgE/albumin, serum total IgE/albumin ratio was significantly higher in atopic subjects than in non-atopic subjects as shown in Fig. 2 (p=0.00). When the total IgE level in the nasal polyp tissue was presented as total IgE/tissue albumin ratio, tissue total IgE/albumin ratio was significantly higher in atopic subject than in non-atopic subject (Fig. 2; p<0.05). Three of non-atopic subjects as well as eight of atopic subjects had remarkably high tIgE/albumin (greater than 10). The ratio of tissue total IgE/albumin against serum total IgE/albumin was higher than 1 in all the non-atopic subjects and seven of 10 (70%) atopic subjects as shown in Fig. 3. Serum total IgE/albumin ratio was significantly correlated with tissue total IgE/albumin ratio (Fig. 4; r=0.46, p<0.05).


IgE production from the nasal polyp tissue: comparison between atopic and non-atopic subjects.

Kim HY, Nahm DH, Suh KS, Park HS - Korean J. Intern. Med. (1998)

Comparison of total IgE/albumin ratio from serum and nasal polyp tissue between atopic and non-atopic subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4531951&req=5

f2-kjim-13-2-83-2: Comparison of total IgE/albumin ratio from serum and nasal polyp tissue between atopic and non-atopic subjects.
Mentions: When the serum total IgE level was presented as the ratio of total IgE/albumin, serum total IgE/albumin ratio was significantly higher in atopic subjects than in non-atopic subjects as shown in Fig. 2 (p=0.00). When the total IgE level in the nasal polyp tissue was presented as total IgE/tissue albumin ratio, tissue total IgE/albumin ratio was significantly higher in atopic subject than in non-atopic subject (Fig. 2; p<0.05). Three of non-atopic subjects as well as eight of atopic subjects had remarkably high tIgE/albumin (greater than 10). The ratio of tissue total IgE/albumin against serum total IgE/albumin was higher than 1 in all the non-atopic subjects and seven of 10 (70%) atopic subjects as shown in Fig. 3. Serum total IgE/albumin ratio was significantly correlated with tissue total IgE/albumin ratio (Fig. 4; r=0.46, p<0.05).

Bottom Line: Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10).A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04).The possibility of an isolated local production of IgE antibody was suggested.

View Article: PubMed Central - PubMed

Affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objectives and methods: To confirm the local production of IgE antibody from the nasal polyp tissue, and to evaluate the difference between atopics and non-atopics, nasal polyp tissues were taken from both 10 atopic and 10 non-atopic subjects. The tissue total IgE (tlgE) level was measured by enzyme-linked immunosorbent assay (ELISA) and serum tlgE level by radio-immunoassay. The tissue albumin level was measured by nephelometry, and serum albumin level by Bromocresol green method.

Results: The polyp tissue tlgE/albumin as well as serum tlgE/albumin ratio were significantly higher in atopics than in non-atopics (p < 0.05), with no difference in the albumin level between the two groups (p > 0.05). Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10). A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04). The ratio of polyp tlgE/albumin to serum tlgE/albumin was greater than 1 in all of the non-atopic subjects and 7 of 10 atopic subjects.

Conclusion: These findings support the hypothesis that IgE antibody could be locally produced from the nasal polyp tissue of non-atopic subjects as well as atopic subjects. The possibility of an isolated local production of IgE antibody was suggested.

Show MeSH
Related in: MedlinePlus