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Changes of the carotid artery Doppler flow velocity pattern after sublingual nitroglycerin in patients with hypertension.

Jeong JW, Park OK, Park YK, Tei C, Tanaka N - Korean J. Intern. Med. (1998)

Bottom Line: We recorded the right common carotid arterial Doppler flow velocity (BFV) pattern and measured the peak velocities of the percussion wave (P) and late rising tidal wave (T), the ratio of the two (P/T), the time interval between the two peaks corrected by heart rate (P-Tc), systolic flow velocity integral (FVI) and carotid artery diameter (CAD) before and after 0.4 mg dose of subligual nitroglycerin (NTG). 1) In hypertensives, the P wave velocity showed lower and P-Tc interval shorter than those of the normal controls at baseline. 2) After NTG, the P-Tc and P/T increased, but the T and FVI decreased significantly in both groups of subjects. 3) The P/T ratio was less significantly increased after NTG in the hypertensives than in the controls.These results suggest that NTG might have been involved in concomitant reduction and delay of the wave reflection from the peripheral vessels, preferentially in the normal subjects than in hypertensives.The carotid Doppler echography can be useful for the evaluation of the changes of hemodynamics in the peripheral vessel such as carotid artery in hypertensive subjects.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Wonkwang University School of Medicine, Iksan, Korea.

ABSTRACT

Objective: To evaluate the applicability of carotid Doppler echography for the assessment of changes of peripheral hemodynamics in the hypertensives.

Subjects: 28 hypertensives (17 males, 11 females), mean age of 64 yrs and 40 normal controls (24 males, 16 females) mean age of 49 yrs.

Methods: We recorded the right common carotid arterial Doppler flow velocity (BFV) pattern and measured the peak velocities of the percussion wave (P) and late rising tidal wave (T), the ratio of the two (P/T), the time interval between the two peaks corrected by heart rate (P-Tc), systolic flow velocity integral (FVI) and carotid artery diameter (CAD) before and after 0.4 mg dose of subligual nitroglycerin (NTG).

Results: 1) In hypertensives, the P wave velocity showed lower and P-Tc interval shorter than those of the normal controls at baseline. 2) After NTG, the P-Tc and P/T increased, but the T and FVI decreased significantly in both groups of subjects. 3) The P/T ratio was less significantly increased after NTG in the hypertensives than in the controls. These results suggest that NTG might have been involved in concomitant reduction and delay of the wave reflection from the peripheral vessels, preferentially in the normal subjects than in hypertensives.

Conclusions: The carotid Doppler echography can be useful for the evaluation of the changes of hemodynamics in the peripheral vessel such as carotid artery in hypertensive subjects.

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Changes of the carotid Doppler peak velocities of percussion (P), tidal (T) and diastolic wave (D) after sublingual nitroglycerin (NTG) in normal controls and hypertensive subjects.
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f4-kjim-13-1-22-4: Changes of the carotid Doppler peak velocities of percussion (P), tidal (T) and diastolic wave (D) after sublingual nitroglycerin (NTG) in normal controls and hypertensive subjects.

Mentions: In the hypertensives, the P wave velocity showed lower, the P-Tc interval was shorter and the CVR was higher than those of the normal controls at baseline(67±22 cm/sec vs. 93 ± 25 cm/sec, 118 ± 18 msec, vs 146 ± 22 msec, and 0.38 mmHg min/ml vs 0.27 mmHg min/ml, respectively, all p<0.05). After sublingual NTG, both mean systolic and diastolic blood pressures decreased significantly (from 158/83 to 140/78 mmHg), similar to normal controls (from 113/65 to 106/60 mmHg), but heart rate showed increasing tendency in both groups of subjects, 93 to 73 beats/min in normal controls and 73 to 81 beat/min in hypertensives (Fig. 3). The P-Tc interval and the P/T ratio increased significantly (152 ± 19 msec vs 118 ± 18 cm/sec, p<0.01 and 1.8 ± 0.5 vs. 1.3 ± 0.3, p<0.05, respectively), the P velocity increased (73 ± 23 cm/sec vs 67 ± 22 cm/sec, p<0.05), but the T velocity and the FVI decreased significantly after NTG (43 cm/sec vs 53 cm/sec and 0.11 m vs 0.14 m, respectively, p<0.05) in comparison with the baseline values (Fig. 4,5,6). The CAD, CBF and CVR showed no significant changes after NTG(Table 1, Fig. 6). When comparing the variables between the hypertensives and the normal controls, we found the similar changes, those of decreased T velocities and increased P-Tc interval in the Doppler flow velocity pattern before and after NTG except FVI, which decreased significantly in hypertensives after NTG resulting in decrease of CBF.


Changes of the carotid artery Doppler flow velocity pattern after sublingual nitroglycerin in patients with hypertension.

Jeong JW, Park OK, Park YK, Tei C, Tanaka N - Korean J. Intern. Med. (1998)

Changes of the carotid Doppler peak velocities of percussion (P), tidal (T) and diastolic wave (D) after sublingual nitroglycerin (NTG) in normal controls and hypertensive subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4531938&req=5

f4-kjim-13-1-22-4: Changes of the carotid Doppler peak velocities of percussion (P), tidal (T) and diastolic wave (D) after sublingual nitroglycerin (NTG) in normal controls and hypertensive subjects.
Mentions: In the hypertensives, the P wave velocity showed lower, the P-Tc interval was shorter and the CVR was higher than those of the normal controls at baseline(67±22 cm/sec vs. 93 ± 25 cm/sec, 118 ± 18 msec, vs 146 ± 22 msec, and 0.38 mmHg min/ml vs 0.27 mmHg min/ml, respectively, all p<0.05). After sublingual NTG, both mean systolic and diastolic blood pressures decreased significantly (from 158/83 to 140/78 mmHg), similar to normal controls (from 113/65 to 106/60 mmHg), but heart rate showed increasing tendency in both groups of subjects, 93 to 73 beats/min in normal controls and 73 to 81 beat/min in hypertensives (Fig. 3). The P-Tc interval and the P/T ratio increased significantly (152 ± 19 msec vs 118 ± 18 cm/sec, p<0.01 and 1.8 ± 0.5 vs. 1.3 ± 0.3, p<0.05, respectively), the P velocity increased (73 ± 23 cm/sec vs 67 ± 22 cm/sec, p<0.05), but the T velocity and the FVI decreased significantly after NTG (43 cm/sec vs 53 cm/sec and 0.11 m vs 0.14 m, respectively, p<0.05) in comparison with the baseline values (Fig. 4,5,6). The CAD, CBF and CVR showed no significant changes after NTG(Table 1, Fig. 6). When comparing the variables between the hypertensives and the normal controls, we found the similar changes, those of decreased T velocities and increased P-Tc interval in the Doppler flow velocity pattern before and after NTG except FVI, which decreased significantly in hypertensives after NTG resulting in decrease of CBF.

Bottom Line: We recorded the right common carotid arterial Doppler flow velocity (BFV) pattern and measured the peak velocities of the percussion wave (P) and late rising tidal wave (T), the ratio of the two (P/T), the time interval between the two peaks corrected by heart rate (P-Tc), systolic flow velocity integral (FVI) and carotid artery diameter (CAD) before and after 0.4 mg dose of subligual nitroglycerin (NTG). 1) In hypertensives, the P wave velocity showed lower and P-Tc interval shorter than those of the normal controls at baseline. 2) After NTG, the P-Tc and P/T increased, but the T and FVI decreased significantly in both groups of subjects. 3) The P/T ratio was less significantly increased after NTG in the hypertensives than in the controls.These results suggest that NTG might have been involved in concomitant reduction and delay of the wave reflection from the peripheral vessels, preferentially in the normal subjects than in hypertensives.The carotid Doppler echography can be useful for the evaluation of the changes of hemodynamics in the peripheral vessel such as carotid artery in hypertensive subjects.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Wonkwang University School of Medicine, Iksan, Korea.

ABSTRACT

Objective: To evaluate the applicability of carotid Doppler echography for the assessment of changes of peripheral hemodynamics in the hypertensives.

Subjects: 28 hypertensives (17 males, 11 females), mean age of 64 yrs and 40 normal controls (24 males, 16 females) mean age of 49 yrs.

Methods: We recorded the right common carotid arterial Doppler flow velocity (BFV) pattern and measured the peak velocities of the percussion wave (P) and late rising tidal wave (T), the ratio of the two (P/T), the time interval between the two peaks corrected by heart rate (P-Tc), systolic flow velocity integral (FVI) and carotid artery diameter (CAD) before and after 0.4 mg dose of subligual nitroglycerin (NTG).

Results: 1) In hypertensives, the P wave velocity showed lower and P-Tc interval shorter than those of the normal controls at baseline. 2) After NTG, the P-Tc and P/T increased, but the T and FVI decreased significantly in both groups of subjects. 3) The P/T ratio was less significantly increased after NTG in the hypertensives than in the controls. These results suggest that NTG might have been involved in concomitant reduction and delay of the wave reflection from the peripheral vessels, preferentially in the normal subjects than in hypertensives.

Conclusions: The carotid Doppler echography can be useful for the evaluation of the changes of hemodynamics in the peripheral vessel such as carotid artery in hypertensive subjects.

Show MeSH