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The imbalance between coagulation and fibrinolysis is related to the severity of the illness and the prognosis in sepsis.

Park KJ, Kim HJ, Hwang SC, Lee SM, Lee YH, Hahn MH, Kim SK, Lee WY - Korean J. Intern. Med. (1999)

Bottom Line: Nonsurvivors showed greater levels of TAT (21.7 +/- 22.3 ng/mL) and lower levels of PAP (628.4 +/- 378.1 ng/mL) than survivors (TAT: 11.1 +/- 11.2 ng/mL; PAP: 857.1 +/- 364.1 ng/mL).The imbalance between coagulation and fibrinolysis described as TAT/PAP ratio was closely related with APACHE III scores in patients with sepsis (r = 0.47) and the TAT/PAP ratio in nonsurvivors was significantly higher compared with survivors (34.4 +/- 21.4 vs. 14.4 +/- 13.8).In sepsis, both coagulation and the fibrinolysis system are activated and the imbalance between coagulation and fibrinolysis predisposes to the hypercoagulation state and is closely related to the severity of the disease and the prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objectives: The coagulation and fibrinolytic system appears to be activated by the septic process independently, leading to the syndrome of disseminated intravascular coagulation (DIC). In this study, we investigated the changes within the hemostatic system related to the severity of the illness and the prognosis in patients with sepsis.

Methods: Plasma thrombin-antithrombin III (TAT) and plasmin-alpha 2-antiplasmin (PAP) complexes were measured using ELISA methods in 32 patients with sepsis and 20 controls and were analyzed according to the APACHE III scores and survival of the patients.

Results: Plasma TAT and PAP in patients with sepsis were significantly higher than controls. Nonsurvivors showed greater levels of TAT (21.7 +/- 22.3 ng/mL) and lower levels of PAP (628.4 +/- 378.1 ng/mL) than survivors (TAT: 11.1 +/- 11.2 ng/mL; PAP: 857.1 +/- 364.1 ng/mL). The imbalance between coagulation and fibrinolysis described as TAT/PAP ratio was closely related with APACHE III scores in patients with sepsis (r = 0.47) and the TAT/PAP ratio in nonsurvivors was significantly higher compared with survivors (34.4 +/- 21.4 vs. 14.4 +/- 13.8).

Conclusion: In sepsis, both coagulation and the fibrinolysis system are activated and the imbalance between coagulation and fibrinolysis predisposes to the hypercoagulation state and is closely related to the severity of the disease and the prognosis.

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Related in: MedlinePlus

Plasma concentration of TAT in control group and sepsis patients.
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f1-kjim-14-2-72-11: Plasma concentration of TAT in control group and sepsis patients.

Mentions: Plasma TAT and PAP in 32 patients with sepsis were 15.1±16.8ng/mL and 771.3±380.3ng/mL and the values in 20 controls were 2.8±1.1ng/mL and 240.4±69.7ng/mL (Fig. 1, 2). Although plasma TAT and PAP in patients with sepsis were significantly higher than those in controls, the TAT/PAP ratio (21.3±19.0, expressed as TAT/PAP × 1,000) in patients with sepsis was not significantly different from that (12.3±4.4) in 20 controls.


The imbalance between coagulation and fibrinolysis is related to the severity of the illness and the prognosis in sepsis.

Park KJ, Kim HJ, Hwang SC, Lee SM, Lee YH, Hahn MH, Kim SK, Lee WY - Korean J. Intern. Med. (1999)

Plasma concentration of TAT in control group and sepsis patients.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4531923&req=5

f1-kjim-14-2-72-11: Plasma concentration of TAT in control group and sepsis patients.
Mentions: Plasma TAT and PAP in 32 patients with sepsis were 15.1±16.8ng/mL and 771.3±380.3ng/mL and the values in 20 controls were 2.8±1.1ng/mL and 240.4±69.7ng/mL (Fig. 1, 2). Although plasma TAT and PAP in patients with sepsis were significantly higher than those in controls, the TAT/PAP ratio (21.3±19.0, expressed as TAT/PAP × 1,000) in patients with sepsis was not significantly different from that (12.3±4.4) in 20 controls.

Bottom Line: Nonsurvivors showed greater levels of TAT (21.7 +/- 22.3 ng/mL) and lower levels of PAP (628.4 +/- 378.1 ng/mL) than survivors (TAT: 11.1 +/- 11.2 ng/mL; PAP: 857.1 +/- 364.1 ng/mL).The imbalance between coagulation and fibrinolysis described as TAT/PAP ratio was closely related with APACHE III scores in patients with sepsis (r = 0.47) and the TAT/PAP ratio in nonsurvivors was significantly higher compared with survivors (34.4 +/- 21.4 vs. 14.4 +/- 13.8).In sepsis, both coagulation and the fibrinolysis system are activated and the imbalance between coagulation and fibrinolysis predisposes to the hypercoagulation state and is closely related to the severity of the disease and the prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objectives: The coagulation and fibrinolytic system appears to be activated by the septic process independently, leading to the syndrome of disseminated intravascular coagulation (DIC). In this study, we investigated the changes within the hemostatic system related to the severity of the illness and the prognosis in patients with sepsis.

Methods: Plasma thrombin-antithrombin III (TAT) and plasmin-alpha 2-antiplasmin (PAP) complexes were measured using ELISA methods in 32 patients with sepsis and 20 controls and were analyzed according to the APACHE III scores and survival of the patients.

Results: Plasma TAT and PAP in patients with sepsis were significantly higher than controls. Nonsurvivors showed greater levels of TAT (21.7 +/- 22.3 ng/mL) and lower levels of PAP (628.4 +/- 378.1 ng/mL) than survivors (TAT: 11.1 +/- 11.2 ng/mL; PAP: 857.1 +/- 364.1 ng/mL). The imbalance between coagulation and fibrinolysis described as TAT/PAP ratio was closely related with APACHE III scores in patients with sepsis (r = 0.47) and the TAT/PAP ratio in nonsurvivors was significantly higher compared with survivors (34.4 +/- 21.4 vs. 14.4 +/- 13.8).

Conclusion: In sepsis, both coagulation and the fibrinolysis system are activated and the imbalance between coagulation and fibrinolysis predisposes to the hypercoagulation state and is closely related to the severity of the disease and the prognosis.

Show MeSH
Related in: MedlinePlus