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Molecular Characterization and Viral Origin of the First Dengue Outbreak in Xishuangbanna, Yunnan Province, China, 2013.

Guo X, Yang H, Wu C, Jiang J, Fan J, Li H, Zhu J, Yang Z, Li Y, Zhou H, Zhang J - Am. J. Trop. Med. Hyg. (2015)

Bottom Line: Dengue virus (DENV) RNA detection in sera or viral isolates revealed that all 222 autochthonous patients detected and three Chinese travelers from Laos (imported cases) were positive for DENV-3 serotype, while DENV-1 and DENV-4 were detected in travelers from Myanmar and Thailand during the outbreak.Further, a random subset of 33 positive cases for DENV-3 was sequenced for the full envelope gene of DENV.These results suggest that the genotype II of DENV-3 was associated with the outbreak and may have originated from the virus circulating in Laos.

View Article: PubMed Central - PubMed

Affiliation: Yunnan Provincial Key Laboratory of Arbo Infectious Disease Control Research (Preparing), Yunnan Institute of Parasitic Diseases, Yunnan, People's Republic of China; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China; Division of Parasitic Diseases Prevention and Control, Xishuangbanna Center for Disease Control and Prevention, Yunnan, People's Republic of China.

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Map of Yunnan Province and neighboring countries. (A) (Jinghong City, Xishuangbanna, Yunnan Province, China) shows the location of dengue outbreak. (B) (Houayxay County, Bokeo Province, Laos) and (D) (Vientiane, Laos) show the locations of imported dengue cases. (B) and (C) (Luang Prabang County, Luang Prabang Province, Laos) show the locations of Laotian cases. Imported case refers to Chinese traveler, who felt ill in Laos, and then came back to China. Laotian case refers to Laotian, who was infected in Laos, and had never traveled abroad.
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Figure 1: Map of Yunnan Province and neighboring countries. (A) (Jinghong City, Xishuangbanna, Yunnan Province, China) shows the location of dengue outbreak. (B) (Houayxay County, Bokeo Province, Laos) and (D) (Vientiane, Laos) show the locations of imported dengue cases. (B) and (C) (Luang Prabang County, Luang Prabang Province, Laos) show the locations of Laotian cases. Imported case refers to Chinese traveler, who felt ill in Laos, and then came back to China. Laotian case refers to Laotian, who was infected in Laos, and had never traveled abroad.

Mentions: Of the 1,254 cases, 360 autochthonous cases were selected mainly based on the onset date of the disease. In addition, eight imported cases, three from Laos (two in August and one in September), three from Myanmar (August), and two from Thailand (August) were confirmed through the dengue surveillance system. Before the outbreak, 33 acute-phase plasma samples were obtained in June 2013 from suspected dengue cases with the dengue fever symptoms, including four Chinese travelers from Houayxay County and Vientiane, Laos (imported cases), and 29 residents living in the Houayxay and Luang Prabang counties in the north of Laos (Laotian cases), where the Joint Control Project of Malaria and Dengue in China's frontier areas adjacent to Laos was under implementation. A total of 401 cases were included in this study. The map of the sampling locations is shown in Figure 1Figure 1.


Molecular Characterization and Viral Origin of the First Dengue Outbreak in Xishuangbanna, Yunnan Province, China, 2013.

Guo X, Yang H, Wu C, Jiang J, Fan J, Li H, Zhu J, Yang Z, Li Y, Zhou H, Zhang J - Am. J. Trop. Med. Hyg. (2015)

Map of Yunnan Province and neighboring countries. (A) (Jinghong City, Xishuangbanna, Yunnan Province, China) shows the location of dengue outbreak. (B) (Houayxay County, Bokeo Province, Laos) and (D) (Vientiane, Laos) show the locations of imported dengue cases. (B) and (C) (Luang Prabang County, Luang Prabang Province, Laos) show the locations of Laotian cases. Imported case refers to Chinese traveler, who felt ill in Laos, and then came back to China. Laotian case refers to Laotian, who was infected in Laos, and had never traveled abroad.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4530767&req=5

Figure 1: Map of Yunnan Province and neighboring countries. (A) (Jinghong City, Xishuangbanna, Yunnan Province, China) shows the location of dengue outbreak. (B) (Houayxay County, Bokeo Province, Laos) and (D) (Vientiane, Laos) show the locations of imported dengue cases. (B) and (C) (Luang Prabang County, Luang Prabang Province, Laos) show the locations of Laotian cases. Imported case refers to Chinese traveler, who felt ill in Laos, and then came back to China. Laotian case refers to Laotian, who was infected in Laos, and had never traveled abroad.
Mentions: Of the 1,254 cases, 360 autochthonous cases were selected mainly based on the onset date of the disease. In addition, eight imported cases, three from Laos (two in August and one in September), three from Myanmar (August), and two from Thailand (August) were confirmed through the dengue surveillance system. Before the outbreak, 33 acute-phase plasma samples were obtained in June 2013 from suspected dengue cases with the dengue fever symptoms, including four Chinese travelers from Houayxay County and Vientiane, Laos (imported cases), and 29 residents living in the Houayxay and Luang Prabang counties in the north of Laos (Laotian cases), where the Joint Control Project of Malaria and Dengue in China's frontier areas adjacent to Laos was under implementation. A total of 401 cases were included in this study. The map of the sampling locations is shown in Figure 1Figure 1.

Bottom Line: Dengue virus (DENV) RNA detection in sera or viral isolates revealed that all 222 autochthonous patients detected and three Chinese travelers from Laos (imported cases) were positive for DENV-3 serotype, while DENV-1 and DENV-4 were detected in travelers from Myanmar and Thailand during the outbreak.Further, a random subset of 33 positive cases for DENV-3 was sequenced for the full envelope gene of DENV.These results suggest that the genotype II of DENV-3 was associated with the outbreak and may have originated from the virus circulating in Laos.

View Article: PubMed Central - PubMed

Affiliation: Yunnan Provincial Key Laboratory of Arbo Infectious Disease Control Research (Preparing), Yunnan Institute of Parasitic Diseases, Yunnan, People's Republic of China; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China; Division of Parasitic Diseases Prevention and Control, Xishuangbanna Center for Disease Control and Prevention, Yunnan, People's Republic of China.

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Related in: MedlinePlus