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Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh.

Falkard B, Uddin T, Rahman MA, Franke MF, Aktar A, Uddin MI, Bhuiyan TR, Leung DT, Charles RC, Larocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET - Am. J. Trop. Med. Hyg. (2015)

Bottom Line: We found that patients at the acute stage of cholera had significantly lower plasma leptin levels than matched controls, and compared with levels in late convalescence.In multivariate analysis, we found an association between day 2 leptin levels and development of later anti-cholera toxin B subunit (CtxB) responses.This finding appeared to be limited to children with better nutritional status.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Bangladesh (icddr,b), Dhaka, Bangladesh; Partners In Health, Boston, Massachusetts; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Division of Infectious Disease, University of Utah School of Medicine, Salt Lake City, Utah; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts bfalkard@partners.org.

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Correlation between leptin on days 2 and 30 IgG responses to Vibrio cholerae O1 lipopolysaccharide (LPS). Nutritional categorization on day 2 of cholera patients. WAZ = weight-for-age; WHZ = weight-for-height; HAZ = height-for-age, as described by World Health Organization anthropometric classifications (http://www.who.int/childgrowth/software/en/). Children with a Z score < −2 were categorized as moderately or severely undernourished for that category. Children with a Z score ≥ −2 were categorized as non-moderately or severely undernourished. P value and R2 values are shown.
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Figure 3: Correlation between leptin on days 2 and 30 IgG responses to Vibrio cholerae O1 lipopolysaccharide (LPS). Nutritional categorization on day 2 of cholera patients. WAZ = weight-for-age; WHZ = weight-for-height; HAZ = height-for-age, as described by World Health Organization anthropometric classifications (http://www.who.int/childgrowth/software/en/). Children with a Z score < −2 were categorized as moderately or severely undernourished for that category. Children with a Z score ≥ −2 were categorized as non-moderately or severely undernourished. P value and R2 values are shown.

Mentions: Correlation between day 2 plasma leptin and day 30 IgG responses to the cholera toxin-B subunit (CtxB). Nutritional categorization on day 2 of cholera patients. WAZ = weight-for-age; WHZ = weight-for-height; HAZ = height-for-age, as described by World Health Organization anthropometric classifications (http://www.who.int/childgrowth/software/en/). Children with a Z score < −2 were categorized as moderately or severely undernourished for that category. Children with a Z score ≥ −2 were categorized as non-moderately or severely undernourished. P value and R2 values are shown.


Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh.

Falkard B, Uddin T, Rahman MA, Franke MF, Aktar A, Uddin MI, Bhuiyan TR, Leung DT, Charles RC, Larocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET - Am. J. Trop. Med. Hyg. (2015)

Correlation between leptin on days 2 and 30 IgG responses to Vibrio cholerae O1 lipopolysaccharide (LPS). Nutritional categorization on day 2 of cholera patients. WAZ = weight-for-age; WHZ = weight-for-height; HAZ = height-for-age, as described by World Health Organization anthropometric classifications (http://www.who.int/childgrowth/software/en/). Children with a Z score < −2 were categorized as moderately or severely undernourished for that category. Children with a Z score ≥ −2 were categorized as non-moderately or severely undernourished. P value and R2 values are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4530742&req=5

Figure 3: Correlation between leptin on days 2 and 30 IgG responses to Vibrio cholerae O1 lipopolysaccharide (LPS). Nutritional categorization on day 2 of cholera patients. WAZ = weight-for-age; WHZ = weight-for-height; HAZ = height-for-age, as described by World Health Organization anthropometric classifications (http://www.who.int/childgrowth/software/en/). Children with a Z score < −2 were categorized as moderately or severely undernourished for that category. Children with a Z score ≥ −2 were categorized as non-moderately or severely undernourished. P value and R2 values are shown.
Mentions: Correlation between day 2 plasma leptin and day 30 IgG responses to the cholera toxin-B subunit (CtxB). Nutritional categorization on day 2 of cholera patients. WAZ = weight-for-age; WHZ = weight-for-height; HAZ = height-for-age, as described by World Health Organization anthropometric classifications (http://www.who.int/childgrowth/software/en/). Children with a Z score < −2 were categorized as moderately or severely undernourished for that category. Children with a Z score ≥ −2 were categorized as non-moderately or severely undernourished. P value and R2 values are shown.

Bottom Line: We found that patients at the acute stage of cholera had significantly lower plasma leptin levels than matched controls, and compared with levels in late convalescence.In multivariate analysis, we found an association between day 2 leptin levels and development of later anti-cholera toxin B subunit (CtxB) responses.This finding appeared to be limited to children with better nutritional status.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Bangladesh (icddr,b), Dhaka, Bangladesh; Partners In Health, Boston, Massachusetts; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Division of Infectious Disease, University of Utah School of Medicine, Salt Lake City, Utah; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts bfalkard@partners.org.

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Related in: MedlinePlus