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Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh.

Falkard B, Uddin T, Rahman MA, Franke MF, Aktar A, Uddin MI, Bhuiyan TR, Leung DT, Charles RC, Larocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET - Am. J. Trop. Med. Hyg. (2015)

Bottom Line: We found that patients at the acute stage of cholera had significantly lower plasma leptin levels than matched controls, and compared with levels in late convalescence.In multivariate analysis, we found an association between day 2 leptin levels and development of later anti-cholera toxin B subunit (CtxB) responses.This finding appeared to be limited to children with better nutritional status.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Bangladesh (icddr,b), Dhaka, Bangladesh; Partners In Health, Boston, Massachusetts; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Division of Infectious Disease, University of Utah School of Medicine, Salt Lake City, Utah; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts bfalkard@partners.org.

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Mean plasma leptin levels on days 2, 7, 30, and 180 in children with cholera in Bangladesh and non-cholera controls (NCCs) matched for age, gender, and weight-for-age (WAZ). * P < 0.05. Error bars represent standard error of the mean.
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Figure 1: Mean plasma leptin levels on days 2, 7, 30, and 180 in children with cholera in Bangladesh and non-cholera controls (NCCs) matched for age, gender, and weight-for-age (WAZ). * P < 0.05. Error bars represent standard error of the mean.

Mentions: We found that leptin levels in plasma from 11 patients were significantly reduced during the acute phase of cholera infection compared with subsequent days of infection, contrary to our initial hypothesis (Figure 1Figure 1.


Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh.

Falkard B, Uddin T, Rahman MA, Franke MF, Aktar A, Uddin MI, Bhuiyan TR, Leung DT, Charles RC, Larocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET - Am. J. Trop. Med. Hyg. (2015)

Mean plasma leptin levels on days 2, 7, 30, and 180 in children with cholera in Bangladesh and non-cholera controls (NCCs) matched for age, gender, and weight-for-age (WAZ). * P < 0.05. Error bars represent standard error of the mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4530742&req=5

Figure 1: Mean plasma leptin levels on days 2, 7, 30, and 180 in children with cholera in Bangladesh and non-cholera controls (NCCs) matched for age, gender, and weight-for-age (WAZ). * P < 0.05. Error bars represent standard error of the mean.
Mentions: We found that leptin levels in plasma from 11 patients were significantly reduced during the acute phase of cholera infection compared with subsequent days of infection, contrary to our initial hypothesis (Figure 1Figure 1.

Bottom Line: We found that patients at the acute stage of cholera had significantly lower plasma leptin levels than matched controls, and compared with levels in late convalescence.In multivariate analysis, we found an association between day 2 leptin levels and development of later anti-cholera toxin B subunit (CtxB) responses.This finding appeared to be limited to children with better nutritional status.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Bangladesh (icddr,b), Dhaka, Bangladesh; Partners In Health, Boston, Massachusetts; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Division of Infectious Disease, University of Utah School of Medicine, Salt Lake City, Utah; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts bfalkard@partners.org.

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Related in: MedlinePlus