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Association of chemerin levels with anthropometric indexes and C-reactive protein in obese and non-obese adolescents.

Maghsoudi Z, Kelishadi R, Hosseinzadeh-Attar MJ - ARYA Atheroscler (2015)

Bottom Line: We found a negative significant association between chemerin and adiponectin levels in both obese and non-obese groups(r =-0.387, P = 0.014 vs. r = 0.362, respectively, P = 0.018).Chemerin concentrations had significant positive correlation with Hs-CRP levels, BMI, WC, HC, WHR, body fat mass and its percent (P < 0.05).Chemerin concentrations were associated with and adiponectin levels in obese girl adolescents, negatively.

View Article: PubMed Central - PubMed

Affiliation: Food Security Research Center AND School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Obesity is a low-grade chronic inflammation. This epidemic is growing in different age groups including adolescents. It is accompanied with a decrease in the age for incidence of obesity-related disorders. Chemerin, as a chemokine and stimulator of anti-inflammatory adiponectin, links immune system, adipose tissue and inflammation. It may be useful in predicting obesity in the hit phase of life. This study aims to assess serum chemerin and adiponectin in relation to the inflammation and obesity indices.

Methods: This case-control study was conducted on 82 adolescent girls, aged12-18 years. They were categorized based on the percentiles of the body mass index (BMI).Serum chemerin, adiponectin, high-sensitive C-reactive protein (Hs-CRP), body fat mass and its percent, waist circumference (WC) ,hip circumference (HC) were measured; BMI and waist-to-hip ratio (WHR)were calculated. Data were analyzed by independent Student's t-test and Pearson correlation; path analysis was conducted, as well.

Results: We found a negative significant association between chemerin and adiponectin levels in both obese and non-obese groups(r =-0.387, P = 0.014 vs. r = 0.362, respectively, P = 0.018). Serum chemerin was higher in obese than in non-obese adolescents (441.83 ± 47.79 vs. 409.30 ± 66.12 µg /l, respectively, P = 0.012), whereas mean adiponectin level was lower in obese participants than in the other group (4.79 ± 0.94 versus 5.2 ± 0.53µg/ml, respectively, P = 0.016). Chemerin concentrations had significant positive correlation with Hs-CRP levels, BMI, WC, HC, WHR, body fat mass and its percent (P < 0.05).

Conclusion: Chemerin concentrations were associated with and adiponectin levels in obese girl adolescents, negatively. Hs-CRP, BMI, WC, HC, WHR, body fat mass and its' percent were in positive relation with chemerin levels, and inverse association with serum adiponectin concentrations. Our findings suggest that chemerin can be considered as an early marker of the inflammatory process in obesity.

No MeSH data available.


Related in: MedlinePlus

Path analytical diagram between chemerin,adiponectin and obesity indicesHC: Hip circumference; BMI: Body mass index; WC:Waist circumference; Hs-CRP: High sensitiveC-reactive protein
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f1-ARYA-11-102: Path analytical diagram between chemerin,adiponectin and obesity indicesHC: Hip circumference; BMI: Body mass index; WC:Waist circumference; Hs-CRP: High sensitiveC-reactive protein

Mentions: A sample consisted of 40 obese and 42 normal-weight girl adolescents were studied. Demographic and clinical characteristics of the population are presented in table 1. Participants were categorized in post-pubertal stage (Stage V). There was not significant difference between demographic characteristics of participants (data not shown). There was a negative association between chemerin and adiponectin levels in both groups (Pearson correlation, r = -0.387, P = 0.014 vs. r = -0.362, P = 0.018, respectively). Chemerin levels were higher in obese group than normal-weight adolescents. There was a positive association between chemerin levels and BMI in all of the adolescents, significantly. The same association was seen between chemerin concentrations and WC (Pearson correlation, r = +0.451, P = 0.004 vs. r = 0.317, P = 0.041, respectively), HC (Pearson correlation, r = +0.338, P = 0.036 vs. r = +0.349, P = 0.027, respectively), WHR (Pearson correlation, r = +0.419, P = 0.007 vs. r = +0.325, P = 0.036, respectively), body fat mass (Pearson correlation, r = +0.366, P = 0.020 vs. r = +0.352, P = 0.028, respectively) and its’ percent (Pearson correlation, r = +0. 416, P = 0.008 vs. r = +0.423, P = 0.005). We found a positive correlation between serum chemerin and Hs-CRP levels in obese adolescents (Pearson correlation, r = +0.325, P = 0.047). There adiponectin levels were higher in normal-weight girls than obese group (P = 0.018). Adiponectin concentrations was inversely correlated with BMI (Pearson correlation, r = -0.369, P = 0.019 vs. r = -0.421, P = 0.018, respectively), WC (Pearson correlation, r = -0.427, P = 0.007 vs. r = -0.423, P = 0.005, respectively), HC (Pearson correlation, r = -0.390, P = 0.014 vs. r = -0.333, P = 0.036, respectively), WHR (Pearson correlation, r = -0.361, P = 0.022 vs. r = -0.312, P = 0.044, respectively), body fat mass (Pearson correlation, r = -0.528, P < 0.0001 vs. r = -0.346, P = 0.031, respectively) and its’ percent (Pearson correlation, r = -0.386, P = 0.014 vs. r = -0.340, P = 0.028, respectively) in obese and normal-weight girls (P < 0.05).We observed a negative association between adiponectin and Hs-CRP concentrations in obese adolescents (Pearson correlation, r = -0.361, P = 0.026). Estimated value for the standardized regression weights of the relation between chemerin and adiponectin levels with general, central obesity indices and Hs-CRP are shown in table 2. Path analytical diagram between chemerin, adiponectin and obesity indices is represented in figure 1.


Association of chemerin levels with anthropometric indexes and C-reactive protein in obese and non-obese adolescents.

Maghsoudi Z, Kelishadi R, Hosseinzadeh-Attar MJ - ARYA Atheroscler (2015)

Path analytical diagram between chemerin,adiponectin and obesity indicesHC: Hip circumference; BMI: Body mass index; WC:Waist circumference; Hs-CRP: High sensitiveC-reactive protein
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4530657&req=5

f1-ARYA-11-102: Path analytical diagram between chemerin,adiponectin and obesity indicesHC: Hip circumference; BMI: Body mass index; WC:Waist circumference; Hs-CRP: High sensitiveC-reactive protein
Mentions: A sample consisted of 40 obese and 42 normal-weight girl adolescents were studied. Demographic and clinical characteristics of the population are presented in table 1. Participants were categorized in post-pubertal stage (Stage V). There was not significant difference between demographic characteristics of participants (data not shown). There was a negative association between chemerin and adiponectin levels in both groups (Pearson correlation, r = -0.387, P = 0.014 vs. r = -0.362, P = 0.018, respectively). Chemerin levels were higher in obese group than normal-weight adolescents. There was a positive association between chemerin levels and BMI in all of the adolescents, significantly. The same association was seen between chemerin concentrations and WC (Pearson correlation, r = +0.451, P = 0.004 vs. r = 0.317, P = 0.041, respectively), HC (Pearson correlation, r = +0.338, P = 0.036 vs. r = +0.349, P = 0.027, respectively), WHR (Pearson correlation, r = +0.419, P = 0.007 vs. r = +0.325, P = 0.036, respectively), body fat mass (Pearson correlation, r = +0.366, P = 0.020 vs. r = +0.352, P = 0.028, respectively) and its’ percent (Pearson correlation, r = +0. 416, P = 0.008 vs. r = +0.423, P = 0.005). We found a positive correlation between serum chemerin and Hs-CRP levels in obese adolescents (Pearson correlation, r = +0.325, P = 0.047). There adiponectin levels were higher in normal-weight girls than obese group (P = 0.018). Adiponectin concentrations was inversely correlated with BMI (Pearson correlation, r = -0.369, P = 0.019 vs. r = -0.421, P = 0.018, respectively), WC (Pearson correlation, r = -0.427, P = 0.007 vs. r = -0.423, P = 0.005, respectively), HC (Pearson correlation, r = -0.390, P = 0.014 vs. r = -0.333, P = 0.036, respectively), WHR (Pearson correlation, r = -0.361, P = 0.022 vs. r = -0.312, P = 0.044, respectively), body fat mass (Pearson correlation, r = -0.528, P < 0.0001 vs. r = -0.346, P = 0.031, respectively) and its’ percent (Pearson correlation, r = -0.386, P = 0.014 vs. r = -0.340, P = 0.028, respectively) in obese and normal-weight girls (P < 0.05).We observed a negative association between adiponectin and Hs-CRP concentrations in obese adolescents (Pearson correlation, r = -0.361, P = 0.026). Estimated value for the standardized regression weights of the relation between chemerin and adiponectin levels with general, central obesity indices and Hs-CRP are shown in table 2. Path analytical diagram between chemerin, adiponectin and obesity indices is represented in figure 1.

Bottom Line: We found a negative significant association between chemerin and adiponectin levels in both obese and non-obese groups(r =-0.387, P = 0.014 vs. r = 0.362, respectively, P = 0.018).Chemerin concentrations had significant positive correlation with Hs-CRP levels, BMI, WC, HC, WHR, body fat mass and its percent (P < 0.05).Chemerin concentrations were associated with and adiponectin levels in obese girl adolescents, negatively.

View Article: PubMed Central - PubMed

Affiliation: Food Security Research Center AND School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Obesity is a low-grade chronic inflammation. This epidemic is growing in different age groups including adolescents. It is accompanied with a decrease in the age for incidence of obesity-related disorders. Chemerin, as a chemokine and stimulator of anti-inflammatory adiponectin, links immune system, adipose tissue and inflammation. It may be useful in predicting obesity in the hit phase of life. This study aims to assess serum chemerin and adiponectin in relation to the inflammation and obesity indices.

Methods: This case-control study was conducted on 82 adolescent girls, aged12-18 years. They were categorized based on the percentiles of the body mass index (BMI).Serum chemerin, adiponectin, high-sensitive C-reactive protein (Hs-CRP), body fat mass and its percent, waist circumference (WC) ,hip circumference (HC) were measured; BMI and waist-to-hip ratio (WHR)were calculated. Data were analyzed by independent Student's t-test and Pearson correlation; path analysis was conducted, as well.

Results: We found a negative significant association between chemerin and adiponectin levels in both obese and non-obese groups(r =-0.387, P = 0.014 vs. r = 0.362, respectively, P = 0.018). Serum chemerin was higher in obese than in non-obese adolescents (441.83 ± 47.79 vs. 409.30 ± 66.12 µg /l, respectively, P = 0.012), whereas mean adiponectin level was lower in obese participants than in the other group (4.79 ± 0.94 versus 5.2 ± 0.53µg/ml, respectively, P = 0.016). Chemerin concentrations had significant positive correlation with Hs-CRP levels, BMI, WC, HC, WHR, body fat mass and its percent (P < 0.05).

Conclusion: Chemerin concentrations were associated with and adiponectin levels in obese girl adolescents, negatively. Hs-CRP, BMI, WC, HC, WHR, body fat mass and its' percent were in positive relation with chemerin levels, and inverse association with serum adiponectin concentrations. Our findings suggest that chemerin can be considered as an early marker of the inflammatory process in obesity.

No MeSH data available.


Related in: MedlinePlus