Limits...
Bronchopulmonary dysplasia - an overview about pathophysiologic concepts.

Niedermaier S, Hilgendorff A - Mol Cell Pediatr (2015)

Bottom Line: Neonatal chronic lung disease in the preterm infant, i.e. bronchopulmonary dysplasia (BPD) is characterized by impaired pulmonary development with its effects persisting into adulthood.The current review focuses on selected pathophysiologic processes and their interplay in disease development.Furthermore, the potential of both, acute and long-term changes to the pulmonary scaffold and the cellular interface in concert with dysregulated growth factor signaling to affect aging and repair processes in the adult lung is discussed.

View Article: PubMed Central - PubMed

Affiliation: Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich Max-Lebsche-Platz 31, 81377, Munich, Germany. Sophie.Niedermaier@med.uni-muenchen.de.

ABSTRACT
Neonatal chronic lung disease in the preterm infant, i.e. bronchopulmonary dysplasia (BPD) is characterized by impaired pulmonary development with its effects persisting into adulthood. Triggered in the immature lung by infectious complications, oxygen toxicity and the impact of mechanical ventilation, a sustained inflammatory response, extensive remodeling of the extracellular matrix, increased apoptosis as well as altered growth factor signaling characterize the disease. The current review focuses on selected pathophysiologic processes and their interplay in disease development. Furthermore, the potential of both, acute and long-term changes to the pulmonary scaffold and the cellular interface in concert with dysregulated growth factor signaling to affect aging and repair processes in the adult lung is discussed.

No MeSH data available.


Related in: MedlinePlus

Orchestration of risk factors and pathophysiologic variables with anticipated treatment potential in the development of BPD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4530566&req=5

Fig1: Orchestration of risk factors and pathophysiologic variables with anticipated treatment potential in the development of BPD.

Mentions: This review will focus on key pathophysiologic mechanisms leading to BPD, their interaction with one another, and the potential contribution to long-term lung pathology. Figure 1 depicts a schematic overview of the reviewed processes critical for disease development.Figure 1


Bronchopulmonary dysplasia - an overview about pathophysiologic concepts.

Niedermaier S, Hilgendorff A - Mol Cell Pediatr (2015)

Orchestration of risk factors and pathophysiologic variables with anticipated treatment potential in the development of BPD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4530566&req=5

Fig1: Orchestration of risk factors and pathophysiologic variables with anticipated treatment potential in the development of BPD.
Mentions: This review will focus on key pathophysiologic mechanisms leading to BPD, their interaction with one another, and the potential contribution to long-term lung pathology. Figure 1 depicts a schematic overview of the reviewed processes critical for disease development.Figure 1

Bottom Line: Neonatal chronic lung disease in the preterm infant, i.e. bronchopulmonary dysplasia (BPD) is characterized by impaired pulmonary development with its effects persisting into adulthood.The current review focuses on selected pathophysiologic processes and their interplay in disease development.Furthermore, the potential of both, acute and long-term changes to the pulmonary scaffold and the cellular interface in concert with dysregulated growth factor signaling to affect aging and repair processes in the adult lung is discussed.

View Article: PubMed Central - PubMed

Affiliation: Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich Max-Lebsche-Platz 31, 81377, Munich, Germany. Sophie.Niedermaier@med.uni-muenchen.de.

ABSTRACT
Neonatal chronic lung disease in the preterm infant, i.e. bronchopulmonary dysplasia (BPD) is characterized by impaired pulmonary development with its effects persisting into adulthood. Triggered in the immature lung by infectious complications, oxygen toxicity and the impact of mechanical ventilation, a sustained inflammatory response, extensive remodeling of the extracellular matrix, increased apoptosis as well as altered growth factor signaling characterize the disease. The current review focuses on selected pathophysiologic processes and their interplay in disease development. Furthermore, the potential of both, acute and long-term changes to the pulmonary scaffold and the cellular interface in concert with dysregulated growth factor signaling to affect aging and repair processes in the adult lung is discussed.

No MeSH data available.


Related in: MedlinePlus