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Prediction of the efficacy of surgical intervention in patients with cervical myelopathy by using diffusion tensor 3T-magnetic resonance imaging parameters.

Arima H, Sakamoto S, Naito K, Yamagata T, Uda T, Ohata K, Takami T - J Craniovertebr Junction Spine (2015 Jul-Sep)

Bottom Line: The MD and FA values at the most compressed part were analyzed.Absolute MD and FA values at the most compressed spinal level in patients were transformed into the normalized values with a z-score analysis.MD changes may reflect spinal cord condition and its reversibility.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Osaka City University, Graduate School of Medicine, Osaka, Japan.

ABSTRACT

Background: The clinical significance of diffusion tensor (DT) magnetic resonance imaging (MRI) parameters was analyzed to predict postoperative functional recovery in patients with cervical myelopathy.

Materials and methods: Sixteen patients with cervical myelopathy caused by cervical spondylosis, disk herniation or ossification of the posterior longitudinal ligament who underwent surgical intervention in our institute were enrolled in this retrospective study. There were 7 men and 9 women, with a mean age of 62.8 years. Clinical assessment was done before surgery and at least 3 months after surgery. All patients underwent whole-body 3.0-Tesla MRI before surgery. DT images (DTIs) were obtained using a single-shot fast spin-echo-based sequence. Mean values of mean diffusivity (MD) and fractional anisotropy (FA) at 6 disk levels of the cervical spine were measured using manual setting of regions of interest. The MD and FA values at the most compressed part were analyzed. Absolute MD and FA values at the most compressed spinal level in patients were transformed into the normalized values with a z-score analysis.

Results: MD-z may decrease with the severity of cervical myelopathy. Receiver operating characteristic analysis of MD-z and FA-z suggested that both MD-z and FA-z have clinical validity for predicting the efficacy of surgical intervention, but MD-z was considered to be the most appropriate value to predict the efficacy of surgery.

Conclusions: DTIs may be a promising modality to predict functional recovery after surgery. MD changes may reflect spinal cord condition and its reversibility.

No MeSH data available.


Related in: MedlinePlus

Clinical correlations between diffusion tensor image parameters and preoperative neurosurgical cervical spine scale (NCSS) scores. Higher mean diffusivity-z correlates well with higher NCSS scores (correlation coefficient = 0.62, P = 0.01), but the correlation between fractional anisotropy-z and preoperative NCSS scores is not significant (correlation coefficient = 0.11, P = 0.68)
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Figure 2: Clinical correlations between diffusion tensor image parameters and preoperative neurosurgical cervical spine scale (NCSS) scores. Higher mean diffusivity-z correlates well with higher NCSS scores (correlation coefficient = 0.62, P = 0.01), but the correlation between fractional anisotropy-z and preoperative NCSS scores is not significant (correlation coefficient = 0.11, P = 0.68)

Mentions: There was a significant correlation between MD-z and preoperative NCSS scores, whereas there was no significant correlation between FA-z and preoperative NCSS scores [Figure 2]. A higher MD-z correlated well with higher NCSS scores, suggesting that MD-z may decrease in accordance with the severity of cervical myelopathy.


Prediction of the efficacy of surgical intervention in patients with cervical myelopathy by using diffusion tensor 3T-magnetic resonance imaging parameters.

Arima H, Sakamoto S, Naito K, Yamagata T, Uda T, Ohata K, Takami T - J Craniovertebr Junction Spine (2015 Jul-Sep)

Clinical correlations between diffusion tensor image parameters and preoperative neurosurgical cervical spine scale (NCSS) scores. Higher mean diffusivity-z correlates well with higher NCSS scores (correlation coefficient = 0.62, P = 0.01), but the correlation between fractional anisotropy-z and preoperative NCSS scores is not significant (correlation coefficient = 0.11, P = 0.68)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4530511&req=5

Figure 2: Clinical correlations between diffusion tensor image parameters and preoperative neurosurgical cervical spine scale (NCSS) scores. Higher mean diffusivity-z correlates well with higher NCSS scores (correlation coefficient = 0.62, P = 0.01), but the correlation between fractional anisotropy-z and preoperative NCSS scores is not significant (correlation coefficient = 0.11, P = 0.68)
Mentions: There was a significant correlation between MD-z and preoperative NCSS scores, whereas there was no significant correlation between FA-z and preoperative NCSS scores [Figure 2]. A higher MD-z correlated well with higher NCSS scores, suggesting that MD-z may decrease in accordance with the severity of cervical myelopathy.

Bottom Line: The MD and FA values at the most compressed part were analyzed.Absolute MD and FA values at the most compressed spinal level in patients were transformed into the normalized values with a z-score analysis.MD changes may reflect spinal cord condition and its reversibility.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Osaka City University, Graduate School of Medicine, Osaka, Japan.

ABSTRACT

Background: The clinical significance of diffusion tensor (DT) magnetic resonance imaging (MRI) parameters was analyzed to predict postoperative functional recovery in patients with cervical myelopathy.

Materials and methods: Sixteen patients with cervical myelopathy caused by cervical spondylosis, disk herniation or ossification of the posterior longitudinal ligament who underwent surgical intervention in our institute were enrolled in this retrospective study. There were 7 men and 9 women, with a mean age of 62.8 years. Clinical assessment was done before surgery and at least 3 months after surgery. All patients underwent whole-body 3.0-Tesla MRI before surgery. DT images (DTIs) were obtained using a single-shot fast spin-echo-based sequence. Mean values of mean diffusivity (MD) and fractional anisotropy (FA) at 6 disk levels of the cervical spine were measured using manual setting of regions of interest. The MD and FA values at the most compressed part were analyzed. Absolute MD and FA values at the most compressed spinal level in patients were transformed into the normalized values with a z-score analysis.

Results: MD-z may decrease with the severity of cervical myelopathy. Receiver operating characteristic analysis of MD-z and FA-z suggested that both MD-z and FA-z have clinical validity for predicting the efficacy of surgical intervention, but MD-z was considered to be the most appropriate value to predict the efficacy of surgery.

Conclusions: DTIs may be a promising modality to predict functional recovery after surgery. MD changes may reflect spinal cord condition and its reversibility.

No MeSH data available.


Related in: MedlinePlus