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Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans.

Tian Y, Li H, Liu P, Xu JM, Irwin MG, Xia Z, Tian G - Mediators Inflamm. (2015)

Bottom Line: In patients, Cap3d+Iso but not Cap1hr+Iso additively reduced postischemic myocardial injury and attenuated postischemic myocardial inflammation.In rabbits, Cap or Iso significantly reduced postischemic myocardial infarction.A joint use of 3-day captopril treatment and isoflurane preconditioning additively attenuated MI/R by reducing oxidative stress and inflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Haikou Municipal Hospital, Affiliated Haikou Hospital Xiangya School of Medicine, Central South University, Haikou 570208, China.

ABSTRACT

Background: Pretreatment with the angiotensin-converting inhibitor captopril or volatile anesthetic isoflurane has, respectively, been shown to attenuate myocardial ischemia reperfusion (MI/R) injury in rodents and in patients. It is unknown whether or not captopril pretreatment and isoflurane preconditioning (Iso) may additively or synergistically attenuate MI/R injury.

Methods and results: Patients selected for heart valve replacement surgery were randomly assigned to five groups: untreated control (Control), captopril pretreatment for 3 days (Cap3d), or single dose captopril (Cap1hr, 1 hour) before surgery with or without Iso (Cap3d+Iso and Cap1hr+Iso). Rabbit MI/R model was induced by occluding coronary artery for 30 min followed by 2-hour reperfusion. Rabbits were randomized to receive sham operation (Sham), MI/R (I/R), captopril (Cap, 24 hours before MI/R), Iso, or the combination of captopril and Iso (Iso+Cap). In patients, Cap3d+Iso but not Cap1hr+Iso additively reduced postischemic myocardial injury and attenuated postischemic myocardial inflammation. In rabbits, Cap or Iso significantly reduced postischemic myocardial infarction. Iso+Cap additively reduced cellular injury that was associated with improved postischemic myocardial functional recovery and reduced myocardial apoptosis and attenuated oxidative stress.

Conclusion: A joint use of 3-day captopril treatment and isoflurane preconditioning additively attenuated MI/R by reducing oxidative stress and inflammation.

No MeSH data available.


Related in: MedlinePlus

Isoflurane (Iso) and captopril (Cap) improved postischemic myocardial function recovery in rabbits. (a) Heart rate, (b) mean arterial pressure (MAP), and (c) rate pressure product (RPP) at baseline and during ischemia and reperfusion. Sham: sham operated control; I/R: rabbits subjected to myocardial ischemia reperfusion (MI/R); Cap: rabbits treated with captopril (25 mg/kg given intravenously 24 h) prior to inducing MI/R; Iso: rabbits received isoflurane preconditioning (15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R); Iso+Cap: rabbits received captopril in combination with Iso. Data are shown as means ± SD, with n = 8 animals per group. #P < 0.05 or P < 0.01 versus Sham, *P < 0.05 versus Baseline.
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fig4: Isoflurane (Iso) and captopril (Cap) improved postischemic myocardial function recovery in rabbits. (a) Heart rate, (b) mean arterial pressure (MAP), and (c) rate pressure product (RPP) at baseline and during ischemia and reperfusion. Sham: sham operated control; I/R: rabbits subjected to myocardial ischemia reperfusion (MI/R); Cap: rabbits treated with captopril (25 mg/kg given intravenously 24 h) prior to inducing MI/R; Iso: rabbits received isoflurane preconditioning (15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R); Iso+Cap: rabbits received captopril in combination with Iso. Data are shown as means ± SD, with n = 8 animals per group. #P < 0.05 or P < 0.01 versus Sham, *P < 0.05 versus Baseline.

Mentions: As shown in Figure 3, heart rate in groups Iso and Cap+Iso was significantly higher than that in other groups at baseline, and during ischemia, and during reperfusion at reperfusion 30 minutes, respectively, while no significant difference was observed among groups during reperfusion at reperfusion 60 minutes and 120 minutes (Figure 4(a)). Mean arterial pressure (MAP) in groups Iso and Cap+Iso was significantly lower than that in other groups and did not differ between groups in baseline, ischemia for 30 minutes, reperfusion for 30 minutes, and reperfusion for 60 minutes, and no significant differences of MAP were observed among groups (Figure 4(b)). Rate pressure product (RPP) in groups Iso and Iso+Cap was significantly lower than that in other groups at baseline, during I/R, and reperfusion, while there was no difference between Iso and Iso+Cap groups (Figure 4(c)).


Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans.

Tian Y, Li H, Liu P, Xu JM, Irwin MG, Xia Z, Tian G - Mediators Inflamm. (2015)

Isoflurane (Iso) and captopril (Cap) improved postischemic myocardial function recovery in rabbits. (a) Heart rate, (b) mean arterial pressure (MAP), and (c) rate pressure product (RPP) at baseline and during ischemia and reperfusion. Sham: sham operated control; I/R: rabbits subjected to myocardial ischemia reperfusion (MI/R); Cap: rabbits treated with captopril (25 mg/kg given intravenously 24 h) prior to inducing MI/R; Iso: rabbits received isoflurane preconditioning (15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R); Iso+Cap: rabbits received captopril in combination with Iso. Data are shown as means ± SD, with n = 8 animals per group. #P < 0.05 or P < 0.01 versus Sham, *P < 0.05 versus Baseline.
© Copyright Policy - open-access
Related In: Results  -  Collection

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fig4: Isoflurane (Iso) and captopril (Cap) improved postischemic myocardial function recovery in rabbits. (a) Heart rate, (b) mean arterial pressure (MAP), and (c) rate pressure product (RPP) at baseline and during ischemia and reperfusion. Sham: sham operated control; I/R: rabbits subjected to myocardial ischemia reperfusion (MI/R); Cap: rabbits treated with captopril (25 mg/kg given intravenously 24 h) prior to inducing MI/R; Iso: rabbits received isoflurane preconditioning (15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R); Iso+Cap: rabbits received captopril in combination with Iso. Data are shown as means ± SD, with n = 8 animals per group. #P < 0.05 or P < 0.01 versus Sham, *P < 0.05 versus Baseline.
Mentions: As shown in Figure 3, heart rate in groups Iso and Cap+Iso was significantly higher than that in other groups at baseline, and during ischemia, and during reperfusion at reperfusion 30 minutes, respectively, while no significant difference was observed among groups during reperfusion at reperfusion 60 minutes and 120 minutes (Figure 4(a)). Mean arterial pressure (MAP) in groups Iso and Cap+Iso was significantly lower than that in other groups and did not differ between groups in baseline, ischemia for 30 minutes, reperfusion for 30 minutes, and reperfusion for 60 minutes, and no significant differences of MAP were observed among groups (Figure 4(b)). Rate pressure product (RPP) in groups Iso and Iso+Cap was significantly lower than that in other groups at baseline, during I/R, and reperfusion, while there was no difference between Iso and Iso+Cap groups (Figure 4(c)).

Bottom Line: In patients, Cap3d+Iso but not Cap1hr+Iso additively reduced postischemic myocardial injury and attenuated postischemic myocardial inflammation.In rabbits, Cap or Iso significantly reduced postischemic myocardial infarction.A joint use of 3-day captopril treatment and isoflurane preconditioning additively attenuated MI/R by reducing oxidative stress and inflammation.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Haikou Municipal Hospital, Affiliated Haikou Hospital Xiangya School of Medicine, Central South University, Haikou 570208, China.

ABSTRACT

Background: Pretreatment with the angiotensin-converting inhibitor captopril or volatile anesthetic isoflurane has, respectively, been shown to attenuate myocardial ischemia reperfusion (MI/R) injury in rodents and in patients. It is unknown whether or not captopril pretreatment and isoflurane preconditioning (Iso) may additively or synergistically attenuate MI/R injury.

Methods and results: Patients selected for heart valve replacement surgery were randomly assigned to five groups: untreated control (Control), captopril pretreatment for 3 days (Cap3d), or single dose captopril (Cap1hr, 1 hour) before surgery with or without Iso (Cap3d+Iso and Cap1hr+Iso). Rabbit MI/R model was induced by occluding coronary artery for 30 min followed by 2-hour reperfusion. Rabbits were randomized to receive sham operation (Sham), MI/R (I/R), captopril (Cap, 24 hours before MI/R), Iso, or the combination of captopril and Iso (Iso+Cap). In patients, Cap3d+Iso but not Cap1hr+Iso additively reduced postischemic myocardial injury and attenuated postischemic myocardial inflammation. In rabbits, Cap or Iso significantly reduced postischemic myocardial infarction. Iso+Cap additively reduced cellular injury that was associated with improved postischemic myocardial functional recovery and reduced myocardial apoptosis and attenuated oxidative stress.

Conclusion: A joint use of 3-day captopril treatment and isoflurane preconditioning additively attenuated MI/R by reducing oxidative stress and inflammation.

No MeSH data available.


Related in: MedlinePlus