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Take Pax6 for a Cortical 6-Pack.

Roberts RG - PLoS Biol. (2015)

Bottom Line: This synopsis examines the implications of a new study that imposes primate-like expression of the transcription factor Pax6 on the developing mouse cortex and finds evidence of primate-like proliferation of neuronal progenitors.

View Article: PubMed Central - PubMed

Affiliation: Public Library of Science, Cambridge, United Kingdom.

ABSTRACT
This synopsis examines the implications of a new study that imposes primate-like expression of the transcription factor Pax6 on the developing mouse cortex and finds evidence of primate-like proliferation of neuronal progenitors.

No MeSH data available.


The effects of a “primate-like” Pax6 expression pattern on the mouse cortex.Each panel shows a slice through the developing mouse cortex, with the outer surface (pia) at the top and the ventricle at the bottom (VZ—ventricular zone; SVZ—subventricular zone; IZ—intermediate zone; CP—cortical plate). The upper panel shows the normal mouse pattern of development, while the lower panel shows the effects of sustaining Pax6 in a primate-like way. The effects include (from left) rotation of the aRG cleavage plane, higher numbers of bRGs, increased proliferation in the SVZ, and more neurons (modified from [2]).
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pbio.1002218.g001: The effects of a “primate-like” Pax6 expression pattern on the mouse cortex.Each panel shows a slice through the developing mouse cortex, with the outer surface (pia) at the top and the ventricle at the bottom (VZ—ventricular zone; SVZ—subventricular zone; IZ—intermediate zone; CP—cortical plate). The upper panel shows the normal mouse pattern of development, while the lower panel shows the effects of sustaining Pax6 in a primate-like way. The effects include (from left) rotation of the aRG cleavage plane, higher numbers of bRGs, increased proliferation in the SVZ, and more neurons (modified from [2]).

Mentions: Therefore the take-home of the study is that when the expression of Pax6 is changed from rodent-like to primate-like, the crucial progenitor cells in the developing mouse cortex also adopt a whole suite of properties that are characteristic of the primate brain—more horizontal cleavage, more bRGs, more proliferation, and more neurons (Fig 1).


Take Pax6 for a Cortical 6-Pack.

Roberts RG - PLoS Biol. (2015)

The effects of a “primate-like” Pax6 expression pattern on the mouse cortex.Each panel shows a slice through the developing mouse cortex, with the outer surface (pia) at the top and the ventricle at the bottom (VZ—ventricular zone; SVZ—subventricular zone; IZ—intermediate zone; CP—cortical plate). The upper panel shows the normal mouse pattern of development, while the lower panel shows the effects of sustaining Pax6 in a primate-like way. The effects include (from left) rotation of the aRG cleavage plane, higher numbers of bRGs, increased proliferation in the SVZ, and more neurons (modified from [2]).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4529146&req=5

pbio.1002218.g001: The effects of a “primate-like” Pax6 expression pattern on the mouse cortex.Each panel shows a slice through the developing mouse cortex, with the outer surface (pia) at the top and the ventricle at the bottom (VZ—ventricular zone; SVZ—subventricular zone; IZ—intermediate zone; CP—cortical plate). The upper panel shows the normal mouse pattern of development, while the lower panel shows the effects of sustaining Pax6 in a primate-like way. The effects include (from left) rotation of the aRG cleavage plane, higher numbers of bRGs, increased proliferation in the SVZ, and more neurons (modified from [2]).
Mentions: Therefore the take-home of the study is that when the expression of Pax6 is changed from rodent-like to primate-like, the crucial progenitor cells in the developing mouse cortex also adopt a whole suite of properties that are characteristic of the primate brain—more horizontal cleavage, more bRGs, more proliferation, and more neurons (Fig 1).

Bottom Line: This synopsis examines the implications of a new study that imposes primate-like expression of the transcription factor Pax6 on the developing mouse cortex and finds evidence of primate-like proliferation of neuronal progenitors.

View Article: PubMed Central - PubMed

Affiliation: Public Library of Science, Cambridge, United Kingdom.

ABSTRACT
This synopsis examines the implications of a new study that imposes primate-like expression of the transcription factor Pax6 on the developing mouse cortex and finds evidence of primate-like proliferation of neuronal progenitors.

No MeSH data available.