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A Closer Look at Obesogens: Lipid Homeostasis Disruption in Daphnia.

Konkel L - Environ. Health Perspect. (2015)

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Obesogenic chemicals promote weight gain in mammals by altering lipid metabolism, which results in increased fat accumulation... In the study, the researchers exposed Daphnia to 0.1 µg/L or 1.0 µg/L of the organometallic pollutant tributyltin (TBT)... Fats are allocated to the formation of a new carapace during the molting stage and are transferred into eggs; as this occurs, triacylglycerol levels drop... Barata and colleagues observed negative effects on reproduction and survival in Daphnia exposed to TBT. “Our findings suggest that TBT disrupted the normal transfer of lipids from adult to egg,” Barata says... Females exposed to TBT also retained more fat droplets after they molted... As adults, offspring of exposed females were less fit—they showed impaired survival and reduced reproduction. “We’ve known for a long time that TBT causes reproductive problems in Daphnia... Previous research has suggested that TBT may disrupt certain hormonal signaling pathways in Daphnia... In this study, the researchers found evidence that TBT activated signaling pathways related to molting and reproduction, presumably by increasing transcription of the retinoid X receptor (RXR) gene... Obesogens are defined as chemicals that produce weight gain by increasing the number and/or size of adipocytes or by modulating lipid metabolism... Although lipid transfer is clearly important for fecundity of the animals, Blumberg points out that “the perturbation of lipid transfer from mother to egg in itself isn’t necessarily an obesogenic effect. ” Blumberg was not involved in the current study... Yet if chemicals that cause mammals to get fatter can also perturb lipid dynamics in an ecological context, there could be implications beyond obesity, says Michele La Merrill, a toxicologist at the University of California, Davis. “Although this study is not evaluating invertebrate obesity, it is showing some changes in lipids, and that might be a problem since lipids are important for a number of cell functions, such as membrane integrity,” she explains.

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Experimental exposure to TBT altered the transport of lipids from mother Daphnia to her eggs, an effect that could be problematic if it were to occur in an ecological context© Hajime Watanabe/doi:10.1371/image.pgen.v07.i03
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d35e124: Experimental exposure to TBT altered the transport of lipids from mother Daphnia to her eggs, an effect that could be problematic if it were to occur in an ecological context© Hajime Watanabe/doi:10.1371/image.pgen.v07.i03


A Closer Look at Obesogens: Lipid Homeostasis Disruption in Daphnia.

Konkel L - Environ. Health Perspect. (2015)

Experimental exposure to TBT altered the transport of lipids from mother Daphnia to her eggs, an effect that could be problematic if it were to occur in an ecological context© Hajime Watanabe/doi:10.1371/image.pgen.v07.i03
© Copyright Policy - public-domain
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4529001&req=5

d35e124: Experimental exposure to TBT altered the transport of lipids from mother Daphnia to her eggs, an effect that could be problematic if it were to occur in an ecological context© Hajime Watanabe/doi:10.1371/image.pgen.v07.i03

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Obesogenic chemicals promote weight gain in mammals by altering lipid metabolism, which results in increased fat accumulation... In the study, the researchers exposed Daphnia to 0.1 µg/L or 1.0 µg/L of the organometallic pollutant tributyltin (TBT)... Fats are allocated to the formation of a new carapace during the molting stage and are transferred into eggs; as this occurs, triacylglycerol levels drop... Barata and colleagues observed negative effects on reproduction and survival in Daphnia exposed to TBT. “Our findings suggest that TBT disrupted the normal transfer of lipids from adult to egg,” Barata says... Females exposed to TBT also retained more fat droplets after they molted... As adults, offspring of exposed females were less fit—they showed impaired survival and reduced reproduction. “We’ve known for a long time that TBT causes reproductive problems in Daphnia... Previous research has suggested that TBT may disrupt certain hormonal signaling pathways in Daphnia... In this study, the researchers found evidence that TBT activated signaling pathways related to molting and reproduction, presumably by increasing transcription of the retinoid X receptor (RXR) gene... Obesogens are defined as chemicals that produce weight gain by increasing the number and/or size of adipocytes or by modulating lipid metabolism... Although lipid transfer is clearly important for fecundity of the animals, Blumberg points out that “the perturbation of lipid transfer from mother to egg in itself isn’t necessarily an obesogenic effect. ” Blumberg was not involved in the current study... Yet if chemicals that cause mammals to get fatter can also perturb lipid dynamics in an ecological context, there could be implications beyond obesity, says Michele La Merrill, a toxicologist at the University of California, Davis. “Although this study is not evaluating invertebrate obesity, it is showing some changes in lipids, and that might be a problem since lipids are important for a number of cell functions, such as membrane integrity,” she explains.

No MeSH data available.


Related in: MedlinePlus