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Arsenic and Blood Pressure: A Long-Term Relationship.

Seltenrich N - Environ. Health Perspect. (2015)

View Article: PubMed Central - PubMed

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Overexposure to naturally occurring arsenic in groundwater and soil can cause a variety of cancers and has been associated with developmental effects, neurotoxicity, diabetes, and cardiovascular disease... In this issue of EHP, researchers provide new evidence of arsenic’s ability to elevate blood pressure, potentially leading to hypertension and more serious clinical outcomes... To gain insight into the link between arsenic exposure and changes in blood pressure, researchers based at the University of Chicago, Columbia University, and New York Langone Medical Center analyzed data for 10,853 individuals participating in the Health Effects of Arsenic Longitudinal Study (HEALS), a long-term prospective cohort study... These individuals were exposed to low to moderately high levels of arsenic from nearly 6,000 contaminated wells in an area of Bangladesh outside the capital of Dhaka. (Senior author Yu Chen, an associate professor of population health at New York University, says the cohort has since been expanded to cover a wider area, including data from 11,000 wells.) “We are trying to reveal the mechanisms that link arsenic exposure and cardiovascular disease,” says first author Jieying Jiang. “We think that increasing blood pressure level might be one of those mechanisms. ” Other potential mechanisms include atherosclerosis, oxidative stress, inflammation, and vascular stiffness, which are interrelated and associated with blood pressure, Chen notes. “The issue with arsenic and hypertension has always been a little more controversial than other outcomes,” says Ana Navas-Acien, coauthor of a 2012 review of the subject... Even when controlling for age, sex, smoking status, educational status, and diabetes history, the researchers saw an average annual increase in systolic blood pressure of 0.43 mmHg for participants exposed to medium-low levels of arsenic in groundwater (12–62 µg/L), 0.54 mmHg for those exposed to medium-high levels (62–148 µg/L), and 0.48 mmHg for those exposed to high levels (above 148 µg/L), as compared with the control group, which was exposed to levels below 12 µg/L... The authors speculate that baseline blood pressure could have already been affected significantly by past arsenic exposure, such that only a limited increase could be further observed... The results thus reveal a nonmonotonic dose response, in which individuals exposed to the highest arsenic levels in the study often had a smaller increase than those exposed to medium-high levels... In vitro research has shown arsenic to have a nonlinear effect on blood vessel formation and tumor growth... In any case, while the observed increases are moderate enough that they don’t point directly to clinical outcomes at the individual level, Navas-Acien says that across a broadly exposed population such as Bangladesh’s, they could translate to more people with hypertension and cardiovascular disease. “If even a small portion of cardiovascular disease can be due to arsenic,” Chen agrees, “that may mean a lot of numbers. ”

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Related in: MedlinePlus

Widespread arsenic exposure via drinking water in Bangladesh has been called the “largest mass poisoning of a population in history.”10© SK Hasan Ali/Demotix/Corbis
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d35e119: Widespread arsenic exposure via drinking water in Bangladesh has been called the “largest mass poisoning of a population in history.”10© SK Hasan Ali/Demotix/Corbis


Arsenic and Blood Pressure: A Long-Term Relationship.

Seltenrich N - Environ. Health Perspect. (2015)

Widespread arsenic exposure via drinking water in Bangladesh has been called the “largest mass poisoning of a population in history.”10© SK Hasan Ali/Demotix/Corbis
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4529000&req=5

d35e119: Widespread arsenic exposure via drinking water in Bangladesh has been called the “largest mass poisoning of a population in history.”10© SK Hasan Ali/Demotix/Corbis

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Overexposure to naturally occurring arsenic in groundwater and soil can cause a variety of cancers and has been associated with developmental effects, neurotoxicity, diabetes, and cardiovascular disease... In this issue of EHP, researchers provide new evidence of arsenic’s ability to elevate blood pressure, potentially leading to hypertension and more serious clinical outcomes... To gain insight into the link between arsenic exposure and changes in blood pressure, researchers based at the University of Chicago, Columbia University, and New York Langone Medical Center analyzed data for 10,853 individuals participating in the Health Effects of Arsenic Longitudinal Study (HEALS), a long-term prospective cohort study... These individuals were exposed to low to moderately high levels of arsenic from nearly 6,000 contaminated wells in an area of Bangladesh outside the capital of Dhaka. (Senior author Yu Chen, an associate professor of population health at New York University, says the cohort has since been expanded to cover a wider area, including data from 11,000 wells.) “We are trying to reveal the mechanisms that link arsenic exposure and cardiovascular disease,” says first author Jieying Jiang. “We think that increasing blood pressure level might be one of those mechanisms. ” Other potential mechanisms include atherosclerosis, oxidative stress, inflammation, and vascular stiffness, which are interrelated and associated with blood pressure, Chen notes. “The issue with arsenic and hypertension has always been a little more controversial than other outcomes,” says Ana Navas-Acien, coauthor of a 2012 review of the subject... Even when controlling for age, sex, smoking status, educational status, and diabetes history, the researchers saw an average annual increase in systolic blood pressure of 0.43 mmHg for participants exposed to medium-low levels of arsenic in groundwater (12–62 µg/L), 0.54 mmHg for those exposed to medium-high levels (62–148 µg/L), and 0.48 mmHg for those exposed to high levels (above 148 µg/L), as compared with the control group, which was exposed to levels below 12 µg/L... The authors speculate that baseline blood pressure could have already been affected significantly by past arsenic exposure, such that only a limited increase could be further observed... The results thus reveal a nonmonotonic dose response, in which individuals exposed to the highest arsenic levels in the study often had a smaller increase than those exposed to medium-high levels... In vitro research has shown arsenic to have a nonlinear effect on blood vessel formation and tumor growth... In any case, while the observed increases are moderate enough that they don’t point directly to clinical outcomes at the individual level, Navas-Acien says that across a broadly exposed population such as Bangladesh’s, they could translate to more people with hypertension and cardiovascular disease. “If even a small portion of cardiovascular disease can be due to arsenic,” Chen agrees, “that may mean a lot of numbers. ”

No MeSH data available.


Related in: MedlinePlus