Limits...
Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong.

Chan DP, Lin AW, Wong KH, Wong NS, Lee SS - Virol. J. (2015)

Bottom Line: Detection and molecular characterization of HCV was successfully performed in 22 (91.7 %) patients.There was otherwise no temporal or genetic clustering of the corresponding HIV sequences.The transmission dynamics of HIV and HCV infections in MSM in Hong Kong were evidently unrelated.

View Article: PubMed Central - PubMed

Affiliation: Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China. denisechan@cuhk.edu.hk.

ABSTRACT

Background: Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV infection in HIV-positive MSM in Hong Kong using a molecular approach.

Findings: We retrospectively examined 24 HIV-positive MSM with acute HCV infection diagnosed between 2009 and 2014 in Hong Kong. Detection and molecular characterization of HCV was successfully performed in 22 (91.7 %) patients. Genotype 3a was the most prevalent as identified in 14 (63.6 %) MSM, followed by 1a in 4 (18.2 %), 6a in 2 (9.1 %), and 1each (4.5 %) for 1b and 2a. The high prevalence of genotype 3a in MSM was in stark contrast to its rarity among HCV infected injection drug users (IDU) in Hong Kong. Phylogenetic analyses revealed a monophyletic HCV-3a cluster composing of MSM without injection history, and a homologous pair with HCV-6a genotype. There was otherwise no temporal or genetic clustering of the corresponding HIV sequences.

Conclusions: The origin of sexually acquired acute HCV infections in HIV-positive MSM was diverse and not directly linked with local IDU. The transmission dynamics of HIV and HCV infections in MSM in Hong Kong were evidently unrelated.

No MeSH data available.


Related in: MedlinePlus

Association between HCV and HIV diagnoses by year and HCV genotypes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4528697&req=5

Fig1: Association between HCV and HIV diagnoses by year and HCV genotypes

Mentions: This study was approved by Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee. Between August 2009 and March 2014, 24 HIV + ve MSM attending the clinic were diagnosed with a recently-acquired HCV infection. The inclusion criteria for the study were anti-HCV seroconversion and/or the detection of positive HCV RNA within the preceding 12 months, in the presence of negative anti-HCV status from previous testing. Some infections were picked up because of deranged liver function and a concurrent diagnosis of sexually transmitted infection (STI) like syphilis, suggesting probable venereal exposure. From the available clinical histories, all infections could be linked to recent episodes of unprotected homosexual contacts. The demographics of HIV/HCV co-infected MSM in our cohort are shown in Table 1. The median age at HCV diagnosis was 32 years (interquartile range [IQR]: 27–41 years). All were ethnic Chinese except 2 Caucasians and 1 non-Chinese Asian, and none gave a history of drug injection. The median interval between HIV diagnosis and HCV seroconversion was 3.1 years (IQR: 1.2–6.5 years). One MSM was diagnosed with HCV infection within 6 months of his HIV diagnosis. The HIV-1 subtype was confirmed in 22 patients: subtype B in 15 (68.2 %), CRF01_AE in 6 (27.3 %) and CRF07_BC in 1 (4.5 %). A majority of the HCV infections diagnosed in these HIV + ve MSM after 2012 belonged to genotype 3a (14/16, 87.5 %) (Fig. 1).Table 1


Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong.

Chan DP, Lin AW, Wong KH, Wong NS, Lee SS - Virol. J. (2015)

Association between HCV and HIV diagnoses by year and HCV genotypes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4528697&req=5

Fig1: Association between HCV and HIV diagnoses by year and HCV genotypes
Mentions: This study was approved by Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee. Between August 2009 and March 2014, 24 HIV + ve MSM attending the clinic were diagnosed with a recently-acquired HCV infection. The inclusion criteria for the study were anti-HCV seroconversion and/or the detection of positive HCV RNA within the preceding 12 months, in the presence of negative anti-HCV status from previous testing. Some infections were picked up because of deranged liver function and a concurrent diagnosis of sexually transmitted infection (STI) like syphilis, suggesting probable venereal exposure. From the available clinical histories, all infections could be linked to recent episodes of unprotected homosexual contacts. The demographics of HIV/HCV co-infected MSM in our cohort are shown in Table 1. The median age at HCV diagnosis was 32 years (interquartile range [IQR]: 27–41 years). All were ethnic Chinese except 2 Caucasians and 1 non-Chinese Asian, and none gave a history of drug injection. The median interval between HIV diagnosis and HCV seroconversion was 3.1 years (IQR: 1.2–6.5 years). One MSM was diagnosed with HCV infection within 6 months of his HIV diagnosis. The HIV-1 subtype was confirmed in 22 patients: subtype B in 15 (68.2 %), CRF01_AE in 6 (27.3 %) and CRF07_BC in 1 (4.5 %). A majority of the HCV infections diagnosed in these HIV + ve MSM after 2012 belonged to genotype 3a (14/16, 87.5 %) (Fig. 1).Table 1

Bottom Line: Detection and molecular characterization of HCV was successfully performed in 22 (91.7 %) patients.There was otherwise no temporal or genetic clustering of the corresponding HIV sequences.The transmission dynamics of HIV and HCV infections in MSM in Hong Kong were evidently unrelated.

View Article: PubMed Central - PubMed

Affiliation: Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China. denisechan@cuhk.edu.hk.

ABSTRACT

Background: Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV infection in HIV-positive MSM in Hong Kong using a molecular approach.

Findings: We retrospectively examined 24 HIV-positive MSM with acute HCV infection diagnosed between 2009 and 2014 in Hong Kong. Detection and molecular characterization of HCV was successfully performed in 22 (91.7 %) patients. Genotype 3a was the most prevalent as identified in 14 (63.6 %) MSM, followed by 1a in 4 (18.2 %), 6a in 2 (9.1 %), and 1each (4.5 %) for 1b and 2a. The high prevalence of genotype 3a in MSM was in stark contrast to its rarity among HCV infected injection drug users (IDU) in Hong Kong. Phylogenetic analyses revealed a monophyletic HCV-3a cluster composing of MSM without injection history, and a homologous pair with HCV-6a genotype. There was otherwise no temporal or genetic clustering of the corresponding HIV sequences.

Conclusions: The origin of sexually acquired acute HCV infections in HIV-positive MSM was diverse and not directly linked with local IDU. The transmission dynamics of HIV and HCV infections in MSM in Hong Kong were evidently unrelated.

No MeSH data available.


Related in: MedlinePlus