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Normal ranges of left ventricular strain in children: a meta-analysis.

Jashari H, Rydberg A, Ibrahimi P, Bajraktari G, Kryeziu L, Jashari F, Henein MY - Cardiovasc Ultrasound (2015)

Bottom Line: Data were combined using a random-effect model.Meta-regression showed LV end diastolic diameter as a significant determinant of variation for LS.Variations among different normal ranges were dependent on the vendor used, LV end-diastolic diameter and age.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

ABSTRACT

Aims: The definition of normal values of two-dimensional speckle-tracking echocardiography derived left ventricular (LV) deformation parameters, is of critical importance for the routine application of this modality in children. The objectives of this study were to perform a meta-analysis of normal ranges for longitudinal, circumferential and radial strain/strain rate values and to identify confounders that may contribute to differences in reported measures.

Methods and results: A systematic search was conducted. Studies describing normal healthy subjects and observational studies that used control groups as a comparison were included. Data were combined using a random-effect model. Effects of demographic, clinical and equipment variables were assessed through meta-regression. The search identified 1,192 subjects form 28 articles. Longitudinal strain (LS) normal mean values varied from -12.9 to -26.5 (mean, -20.5; 95% CI, -20.0 to -21.0). Normal mean values of circumferential strain (CS) varied from -10.5 to -27.0 (mean, -22.06; 95% CI, -21.5 to -22.5). Radial strain (RS) normal mean values varied from 24.9 to 62.1 (mean, 45.4; 95% CI, 43.0 to 47.8). Meta-regression showed LV end diastolic diameter as a significant determinant of variation for LS. Longitudinal systolic strain rate (LSRs) was significantly determined by the age and RS by the type of vendor used.

Conclusion: Variations among different normal ranges were dependent on the vendor used, LV end-diastolic diameter and age. Vendor-independent software for analyzing myocardial deformation in children, using images from different vendors would be the ideal solution for strain measurements or else using the same system for patient's follow up.

No MeSH data available.


Related in: MedlinePlus

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Related In: Results  -  Collection

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Fig1: Paper selection flowchart

Mentions: Our search identified 282 articles. After excluding duplicates and triplicates (n = 97), 185 studies were screened for relevance, from which only 28 fulfilled the inclusion criteria (Fig. 1). All included articles were in English language, even though no language restriction was applied. Some articles had more than one dataset of different age groups. In total, 34 datasets with 1023 subjects were eligible for meta-analysis of LS [27, 17, 28, 12, 11, 29, 30, 5, 31–35, 20, 21, 36–40, 16, 41–44] and 12 articles (13 age group studies) with 323 subjects were eligible for meta-analysis of LSRs [17, 27, 29, 30, 16, 31, 32, 21, 38, 40, 44, 43]. CS was calculated from 16 articles (24 age group studies) [28, 12, 11, 19, 31, 30, 32–34, 45, 41, 40, 46, 16, 39, 44] with a total number of 856 subjects and CSRs was calculated from six articles (six age group studies) with 233 subjects [44, 19, 45, 31, 32, 40]. 10 articles (18 age group studies) with 701 subjects were eligible for meta-analysis of RS [28, 11, 19, 31, 34, 45, 16, 44, 39, 12], while RSRs was not calculated because only three studies of different age groups contained the eligible data for meta-analysis (Tables 1 and 2).Fig. 1


Normal ranges of left ventricular strain in children: a meta-analysis.

Jashari H, Rydberg A, Ibrahimi P, Bajraktari G, Kryeziu L, Jashari F, Henein MY - Cardiovasc Ultrasound (2015)

Paper selection flowchart
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4528396&req=5

Fig1: Paper selection flowchart
Mentions: Our search identified 282 articles. After excluding duplicates and triplicates (n = 97), 185 studies were screened for relevance, from which only 28 fulfilled the inclusion criteria (Fig. 1). All included articles were in English language, even though no language restriction was applied. Some articles had more than one dataset of different age groups. In total, 34 datasets with 1023 subjects were eligible for meta-analysis of LS [27, 17, 28, 12, 11, 29, 30, 5, 31–35, 20, 21, 36–40, 16, 41–44] and 12 articles (13 age group studies) with 323 subjects were eligible for meta-analysis of LSRs [17, 27, 29, 30, 16, 31, 32, 21, 38, 40, 44, 43]. CS was calculated from 16 articles (24 age group studies) [28, 12, 11, 19, 31, 30, 32–34, 45, 41, 40, 46, 16, 39, 44] with a total number of 856 subjects and CSRs was calculated from six articles (six age group studies) with 233 subjects [44, 19, 45, 31, 32, 40]. 10 articles (18 age group studies) with 701 subjects were eligible for meta-analysis of RS [28, 11, 19, 31, 34, 45, 16, 44, 39, 12], while RSRs was not calculated because only three studies of different age groups contained the eligible data for meta-analysis (Tables 1 and 2).Fig. 1

Bottom Line: Data were combined using a random-effect model.Meta-regression showed LV end diastolic diameter as a significant determinant of variation for LS.Variations among different normal ranges were dependent on the vendor used, LV end-diastolic diameter and age.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

ABSTRACT

Aims: The definition of normal values of two-dimensional speckle-tracking echocardiography derived left ventricular (LV) deformation parameters, is of critical importance for the routine application of this modality in children. The objectives of this study were to perform a meta-analysis of normal ranges for longitudinal, circumferential and radial strain/strain rate values and to identify confounders that may contribute to differences in reported measures.

Methods and results: A systematic search was conducted. Studies describing normal healthy subjects and observational studies that used control groups as a comparison were included. Data were combined using a random-effect model. Effects of demographic, clinical and equipment variables were assessed through meta-regression. The search identified 1,192 subjects form 28 articles. Longitudinal strain (LS) normal mean values varied from -12.9 to -26.5 (mean, -20.5; 95% CI, -20.0 to -21.0). Normal mean values of circumferential strain (CS) varied from -10.5 to -27.0 (mean, -22.06; 95% CI, -21.5 to -22.5). Radial strain (RS) normal mean values varied from 24.9 to 62.1 (mean, 45.4; 95% CI, 43.0 to 47.8). Meta-regression showed LV end diastolic diameter as a significant determinant of variation for LS. Longitudinal systolic strain rate (LSRs) was significantly determined by the age and RS by the type of vendor used.

Conclusion: Variations among different normal ranges were dependent on the vendor used, LV end-diastolic diameter and age. Vendor-independent software for analyzing myocardial deformation in children, using images from different vendors would be the ideal solution for strain measurements or else using the same system for patient's follow up.

No MeSH data available.


Related in: MedlinePlus