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Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population.

Zanasi A, Cazzato S, Mazzolini M, Ierna CM, Mastroroberto M, Nardi E, Morselli-Labate AM - Multidiscip Respir Med (2015)

Bottom Line: Two children (4.3 %) reported adverse effects in the group treated with the homeopathic syrup alone, versus 9 children (23.1 %) in the group treated with the homeopathic syrup plus antibiotics (P = 0.020).Our data confirm that the homeopathic treatment in question has potential benefits for cough in children as well, and highlight the strong safety profile of this treatment.Additional antibiotic prescription was not associated with a greater cough reduction, and presented more adverse events than the homeopathic syrup alone.

View Article: PubMed Central - PubMed

Affiliation: Italian Association for Cough Study (AIST), Via Mazzini, 12, 40138 Bologna, Italy.

ABSTRACT

Background: The effectiveness of a homeopathic syrup on cough has been demonstrated in an adult population in a previous double-blind randomized study. The present prospective observational study investigated children affected by wet acute cough caused by non-complicated URTIs, comparing those who received the homeopathic syrup versus those treated with the homeopathic syrup plus antibiotic.

Objectives: The aims were: 1) to assess whether the addition of antibiotics to a symptomatic treatment had a role in reducing the severity and duration of acute cough in a pediatric population, as well as in improving cough resolution; 2) to verify the safety of the two treatments.

Methods: Eighty-five children were enrolled in an open study: 46 children received homeopathic syrup alone for 10 days and 39 children received homeopathic syrup for 10 days plus oral antibiotic treatment (amoxicillin/clavulanate, clarithromycin, and erythromycin) for 7 days. To assess cough severity we used a subjective verbal category-descriptive (VCD) scale.

Results: Cough VCD score was significantly (P < 0.001) reduced in both groups starting from the second day of treatment (-0.52 ± 0.66 in the homeopathic syrup group and -0.56 ± 0.55 in children receiving homeopathic syrup plus oral antibiotic treatment). No significant differences in cough severity or resolution were found between the two groups of children in any of the 28 days of the study. After the first week (day 8) cough was completely resolved in more than one-half of patients in both groups. Two children (4.3 %) reported adverse effects in the group treated with the homeopathic syrup alone, versus 9 children (23.1 %) in the group treated with the homeopathic syrup plus antibiotics (P = 0.020).

Conclusions: Our data confirm that the homeopathic treatment in question has potential benefits for cough in children as well, and highlight the strong safety profile of this treatment. Additional antibiotic prescription was not associated with a greater cough reduction, and presented more adverse events than the homeopathic syrup alone.

No MeSH data available.


Related in: MedlinePlus

Cough resolution during the whole observational period in children affected by wet acute cough caused by non-complicated URTI. The Fisher’s exact test was applied
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Fig2: Cough resolution during the whole observational period in children affected by wet acute cough caused by non-complicated URTI. The Fisher’s exact test was applied

Mentions: The analysis of patients presenting cough (i.e., VCD score greater than 1) on each day of the study is reported in Fig. 2. Cough resolution began on Day 4 (8.7 % in Group 1 and 5.1 % in Group 2) and continued progressively through the entire study period. In particular, after the first week (Day 8) cough was completely resolved in more than one-half of patients in both groups (58.7 % in Group 1 and 53.8 % in Group 2), while 22 % of patients in Group 1 and 17.9 % of patients in Group 2 were still coughing at Day 21. Cough was still reported in 8 patients of Group 1 (17.4 %) and in 5 patients of Group 2 (12.8 %) at the end of the observation, although the cough in those patients did not interfere with daily activities and sleep (i.e., VCD score equal to 2 or 3).Fig. 2


Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population.

Zanasi A, Cazzato S, Mazzolini M, Ierna CM, Mastroroberto M, Nardi E, Morselli-Labate AM - Multidiscip Respir Med (2015)

Cough resolution during the whole observational period in children affected by wet acute cough caused by non-complicated URTI. The Fisher’s exact test was applied
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4527103&req=5

Fig2: Cough resolution during the whole observational period in children affected by wet acute cough caused by non-complicated URTI. The Fisher’s exact test was applied
Mentions: The analysis of patients presenting cough (i.e., VCD score greater than 1) on each day of the study is reported in Fig. 2. Cough resolution began on Day 4 (8.7 % in Group 1 and 5.1 % in Group 2) and continued progressively through the entire study period. In particular, after the first week (Day 8) cough was completely resolved in more than one-half of patients in both groups (58.7 % in Group 1 and 53.8 % in Group 2), while 22 % of patients in Group 1 and 17.9 % of patients in Group 2 were still coughing at Day 21. Cough was still reported in 8 patients of Group 1 (17.4 %) and in 5 patients of Group 2 (12.8 %) at the end of the observation, although the cough in those patients did not interfere with daily activities and sleep (i.e., VCD score equal to 2 or 3).Fig. 2

Bottom Line: Two children (4.3 %) reported adverse effects in the group treated with the homeopathic syrup alone, versus 9 children (23.1 %) in the group treated with the homeopathic syrup plus antibiotics (P = 0.020).Our data confirm that the homeopathic treatment in question has potential benefits for cough in children as well, and highlight the strong safety profile of this treatment.Additional antibiotic prescription was not associated with a greater cough reduction, and presented more adverse events than the homeopathic syrup alone.

View Article: PubMed Central - PubMed

Affiliation: Italian Association for Cough Study (AIST), Via Mazzini, 12, 40138 Bologna, Italy.

ABSTRACT

Background: The effectiveness of a homeopathic syrup on cough has been demonstrated in an adult population in a previous double-blind randomized study. The present prospective observational study investigated children affected by wet acute cough caused by non-complicated URTIs, comparing those who received the homeopathic syrup versus those treated with the homeopathic syrup plus antibiotic.

Objectives: The aims were: 1) to assess whether the addition of antibiotics to a symptomatic treatment had a role in reducing the severity and duration of acute cough in a pediatric population, as well as in improving cough resolution; 2) to verify the safety of the two treatments.

Methods: Eighty-five children were enrolled in an open study: 46 children received homeopathic syrup alone for 10 days and 39 children received homeopathic syrup for 10 days plus oral antibiotic treatment (amoxicillin/clavulanate, clarithromycin, and erythromycin) for 7 days. To assess cough severity we used a subjective verbal category-descriptive (VCD) scale.

Results: Cough VCD score was significantly (P < 0.001) reduced in both groups starting from the second day of treatment (-0.52 ± 0.66 in the homeopathic syrup group and -0.56 ± 0.55 in children receiving homeopathic syrup plus oral antibiotic treatment). No significant differences in cough severity or resolution were found between the two groups of children in any of the 28 days of the study. After the first week (day 8) cough was completely resolved in more than one-half of patients in both groups. Two children (4.3 %) reported adverse effects in the group treated with the homeopathic syrup alone, versus 9 children (23.1 %) in the group treated with the homeopathic syrup plus antibiotics (P = 0.020).

Conclusions: Our data confirm that the homeopathic treatment in question has potential benefits for cough in children as well, and highlight the strong safety profile of this treatment. Additional antibiotic prescription was not associated with a greater cough reduction, and presented more adverse events than the homeopathic syrup alone.

No MeSH data available.


Related in: MedlinePlus